بررسی تأثیر گیاه خرنوب بر پارامترهای مایع منی و ناباروری مردان در مطالعات تجربی انسانی و حیوانی: یک مطالعه مرور سیستماتیک

نوع مقاله : مروری

نویسندگان

1 کارشناس ارشد مامایی، دانشکده پرستاری شیروان، دانشگاه علوم پزشکی خراسان شمالی، شیروان، ایران.

2 کارشناس ارشد مامایی، گروه مامایی، دانشکده علوم پزشکی تربت‌جام، تربت‌جام، ایران.

3 دانشجوی دکتری بهداشت باروری، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی تهران، تهران، ایران. کارشناس ارشد مامایی، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی قم، قم، ایران.

4 مرکز تحقیقات علوم بهداشتی، دانشگاه علوم پزشکی تربت‌حیدریه، تربت‌حیدریه، ایران. استادیار گروه مامایی، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی تربت‌حیدریه، تربت‌حیدریه، ایران.

10.22038/ijogi.2024.74721.5848

چکیده

مقدمه: ناباروری، یک مشکل شایع جهانی می ­باشد که فاکتورهای مردانه در 50-40% موارد، دخیل می ­باشند. از آنجایی که امروزه داروهای مکمل و طب جایگزین برای درمان ناباروی مورد توجه واقع شده است، مطالعه حاضر با هدف تأثیر گیاه خرنوب بر پارامترهای مایع منی و ناباروری مردان در مطالعات تجربی انسانی و حیوانی انجام شد.
روش‌کار: این مطالعه مرور سیستماتیک بر اساس گایدلاین PRISMA، با استفاده از کلید واژه­های فارسی و انگلیسی و همه ترکیبات احتمالی آنها و جستجو در پایگاه‌های اطلاعاتی Science Direct،Magiran ، SID، Web of Science،Pubmed ،Medlib ، Scopus و Google Scholar با کلید واژه‌های مبتنی بر MeSh شامل Siliqua ­(Carob)، Sperm، Testis،Male infertility ، Semenبدون محدودیت زمانی تا آوریل 2023 انجام شد. معیار ورود به مطالعه شامل مطالعات مداخله ­ای انسانی و حیوانی انجام شده بر روی مردان و حیوانات مذکر بود.
یافته­ ها: از مجموع 176 مطالعه به‌دست آمده، 14 مطالعه حیوانی و 3 مطالعه انسانی وارد مطالعه شدند. حیوانات مورد آزمایش در این مطالعات شامل موش، خروس، قوچ و سگ بودند. نتایج اکثر مطالعات نشان می­دهد، گیاه خرنوب باعث بهبود پارامترهای اسپرم مانند غلظت، تحرک پیشرونده، مورفولوژی، قابلیت حیات کیفیت و حجم مایع منی می­ گردد، اما نتایج در مورد تأثیر این گیاه بر فعالیت آنتی ­اکسیدانی، شاخص استرس اکسیداتیو و افزایش توان باروری ضدونقیض می­ باشد.
نتیجه­ گیری: گیاه خرنوب بر برخی پارامترهای اسپرم و باروری مردان مؤثر است، هرچند به‌علت ناکافی بودن تعداد مقالات در برخی موارد و وجود تناقض در نتایج برخی مقالات دیگر، نمی‌توان در مورد این گیاه اظهارنظر قطعی کرد، لذا جهت تعیین اثربخشی قطعی آن توصیه می‌شود مطالعاتی وسیع‌تر، با حجم نمونه بیشتر و روش کار دقیق‌تری طراحی و انجام گردد.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

The Effect of Carob (Ceratonia siliqua) Bean Extract on Semen Parameters and Male Infertility in Human and Animal Experimental Studies: A Systematic Review

نویسندگان [English]

  • Seyyedeh Adeleh Rahmanian 1
  • Mahin Kiyani Mask 2
  • Fatemeh Sadat Mousavi 3
  • Morvarid Irani 4
1 M.Sc. of Midwifery, Shirvan School of Nursing, North Khorasan University of Medical Sciences, Shirvan, Iran.
2 M.Sc. of Midwifery, Department of Midwifery, Torbat Jam School of Medical Sciences, Torbat Jam, Iran.
3 PhD Student in Reproductive Health, School of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran. Iran. M.Sc. of Midwifery, School of Nursing and Midwifery, Qom University of Medical Sciences, Qom, Iran.
4 Health Sciences Research Center, Torbat Heydarieh University of Medical Sciences, Torbat Heydarieh, Iran. Assistant Professor, Department of Midwifery, School of Nursing and Midwifery, Torbat Heydarieh University of Medical Sciences, Torbat Heydarieh, Iran.
چکیده [English]

Introduction: Infertility is a common global problem, approximately 40-50% of which is related to male infertility. Since complementary medications and alternative medicine are recently considered for the treatment of infertility, the current study was conducted with aim to assess the effect of carob on semen parameters and male infertility in human and animal experimental studies.
Methods: This systematic review study was performed based on PRISMA guidelines using Persian and English keywords and their possible combinations and search in the following databases: PubMed, Web of Science, Science Direct, Scopus, Medlib, Persian SID and Magiran databases, and Google Scholar search engine with keywords based on MeSh, including siliqua (carob), sperm, testis, male infertility, and semen without time limit until April 2023. The inclusion criteria were human and animal interventional studies conducted on men and male animals.
Results: Out of a total of 176 studies, 14 animal studies and three human studies entered the study. The experimental animals included rats, roosters, rams, and dogs. The results of most studies indicated that carob improves sperm parameters such as concentration, progressive motility, morphology, viability, quality, and semen volume. However, the results are contradictory regarding its effect on antioxidant activity, oxidative stress index, and increasing fertility.
Conclusion: Carob plant is effective on some parameters of sperm and male fertility, although due to the insufficient number of articles in some cases and the existence of contradictions in the results of some other articles, it is not possible to give a definite opinion about this plant, therefore, to determine its definite effectiveness, it is recommended to design and perform more studies with a larger sample size and a more accurate method.

کلیدواژه‌ها [English]

  • Fertility
  • Carob
  • Semen
  • Male infertility

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مجله زنان، مامایی و نازایی ایران
دوره 26، شماره 11
بهمن 1402
صفحه 71-86

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