ارتباط بین سن اولین بارداری و تعداد زایمان با سندرم متابولیک و اجزای آن: نتایج حاصل از مطالعه کوهورت گیلان

نوع مقاله : اصیل پژوهشی

نویسندگان

1 دانشیار گروه اپیدمیولوژی، مرکز تحقیقات بیماری‌های گوارش و کبد، دانشگاه علوم پزشکی گیلان، رشت، ایران.

2 استادیار گروه اپیدمیولوژی، مرکز تحقیقات بیماری‌های گوارش و کبد، دانشگاه علوم پزشکی گیلان، رشت، ایران.

3 دانشجوی پزشکی، مرکز تحقیقات بیماری های گوارش و کبد، دانشگاه علوم پزشکی گیلان، رشت، ایران.

4 استادیار گروه اپیدمیولوژی، مرکز تحقیقات غربالگری و پیشگیری از سرطان‌های گوارش، دانشگاه علوم پزشکی گیلان، رشت، ایران.

5 استاد گروه بیماری‌های گوارش و کبد بالغین، مرکز تحقیقات بیماری‌های گوارش و کبد، دانشگاه علوم پزشکی گیلان، رشت، ایران.

چکیده

مقدمه: سندرم متابولیک با بسیاری از فاکتور­های مربوط به تولید مثل ارتباط دارد. شناسایی ارتباط بین سندرم متابولیک و شرایط تولید مثلی می­تواند به شناسایی گروه­های پرخطر در معرض بیماری کمک کند. مطالعه حاضر با هدف بررسی ارتباط بین تعداد بارداری و سن اولین حاملگی با سندرم متابولیک و اجزای آن انجام شد.
روش‌کار: این مطالعه مقطعی تحلیلی از مرحله اول مطالعه کوهورت گیلان با جمعیت 10520 نفر و بخشی از مطالعه بزرگ کوهورت بزرگسالان ایران می‌باشد که 5243 زن که حداقل یک بارداری را تجربه کرده بودند، مورد بررسی قرار گرفتند. در این مطالعه اطلاعات دموگرافیک بیماران و نیز اطلاعات مربوط به شرایط تولیدمثلی مانند سن اولین بارداری، تعداد بارداری و شاخص‌های مرتبط با سندرم متابولیک جمع‌آوری شدند. تجزیه و تحلیل داده‌ها با استفاده از نرم‌افزار آماری SPSS (نسخه 21) و آزمون کای اسکوئر، تی‌تست و نسبت شانس تعدیل شده انجام شد. میزان p کمتر از 05/0 معنی‌دار در نظر گرفته شد.
یافته‌ها: شیوع سندرم متابولیک در جمعیت مورد بررسی 2909 نفر (5/55%) بود. پس از تطبیق دادن سایر عوامل همچون سن، سطح اقتصادی اجتماعی و محل سکونت، شانس ابتلاء به سندرم متابولیک در کسانی که اولین بارداری را در 25-20 سالگی تجربه کرده بودند، در مقایسه با سن بارداری کمتر از 20 سال 54% بیشتر بود (029/0=p). پس از تطبیق بر روی سایر عوامل، شانس ابتلاء به سندرم متابولیک در کسانی که 3، 4 و بیش از 5 زایمان داشتند، به‌ترتیب 43/1، 80/1 و 55/2 برابر بیشتر از کسانی بود که 1 زایمان داشتند (001/0p<).
نتیجه‌گیری: سن بالاتر، تعداد زایمان بیشتر از 3 مورد  و بیماری­های مزمن همراه، شانس ابتلاء به سندرم متابولیک را افزایش می­دهد. با توجه به اینکه سندرم متابولیک با طیف گسترده­ای از بیماری­های غیرواگیر ارتباط داد، لزوم اقدامات پیشگیرانه در این افراد توصیه می­شود.

کلیدواژه‌ها

عنوان مقاله [English]

The association between age at first pregnancy and number of deliveries with metabolic syndrome and its components: Results from Persian Guilan Cohort Study (PGCS)

نویسندگان [English]

  • Mohammadreza Naghipour 1
  • Farahnaz Joukar 2
  • Ehsan Amini Salehi 3
  • Soheil Hassanipour 4
  • Fariborz Mansour Ghanaei 5
1 Associate Professor, Department of Epidemiology, Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran.
2 Assistant Professor, Department of Epidemiology, Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran.
3 Medical Student, Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran.
4 Assistant Professor, Department of Epidemiology, GI Cancer Screening and Prevention Research Center, Guilan University of Medical Sciences, Rasht, Iran.
5 Professor, Department of Gastrointestinal and Liver Diseases in Adults, Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran.
چکیده [English]

Introduction: Metabolic syndrome is associated with many factors related to fertility. Identifying the link between metabolic syndrome and reproductive conditions can help us identify high-risk groups for the disease. The present study was performed aimed to investigate the relationship between the age of first pregnancy and number of deliveries with metabolic syndrome and its components.
Methods: This cross-sectional analytical study at the first stage of the Guilan cohort study with 10520 individuals and a part of the PERSIAN adult cohort study with 5243 women who had experienced at least one pregnancy. Patients' demographic information as well as information about reproductive conditions such as first gestational age and number of pregnancies and indicators related to metabolic syndrome were collected. Data were analyzed by SPSS statistical software (version 21) and Chi-square test, t-test and adjusted odds ratio. P< 0.05 was considered statistically significant.
Results: The prevalence of metabolic syndrome in the study population was 55.5% (n=2909). After adjusting other factors such as age, socioeconomic status and place of residence, the chance of developing metabolic syndrome in those who experienced their first pregnancy between the ages of 20-25 were 54% higher than those under the age of 20 (P = 0.029). After adjusting to other factors, those who had 3, 4 and more than 5 deliveries were 1.43, 1.80, and 2.55 times more likely to develop metabolic syndrome, respectively, than those who had one delivery (P<0.001).
Conclusion: Older age, number of births more than three, and associated chronic diseases increase the chance of developing metabolic syndrome. Considering that metabolic syndrome is associated with a wide range of non-communicable diseases, preventive measures are recommended in these individuals.

کلیدواژه‌ها [English]

  • Guilan
  • Metabolic Syndrome
  • PERSIAN Cohort
  • Pregnancy

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مجله زنان، مامایی و نازایی ایران
دوره 25، شماره 6
شهریور 1401
صفحه 1-11

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