کرونا ویروس جدید و محور هیپوتالاموس- هیپوفیز - تخمدان در زنان: یک مرور روایتی

نوع مقاله : مروری

نویسندگان

1 متخصص زنان و نازایی، مرکز تحقیقات سلامت و بیماریهای زنان، دانشکده پزشکی، دانشگاه علوم پزشکی جهرم، جهرم، ایران.

2 دانشیار گروه بیهوشی، فلوشیپ مراقبت‌های ویژه، مرکز تحقیقات بیهوشی، مراقبت‌های ویژه و کنترل درد، دانشکده پزشکی، دانشگاه علوم پزشکی هرمزگان، بندرعباس، ایران.

3 استادیار گروه جراحی، دانشکده پزشکی، دانشگاه علوم پزشکی جهرم، جهرم، ایران.

4 استادیار گروه جراحی پلاستیک، دانشکده پزشکی، دانشگاه علوم پزشکی جهرم، جهرم، ایران.

5 مربی گروه بیهوشی، مرکز تحقیقات مؤلفه های اجتماعی نظام سلامت، دانشکده پرستاری، دانشگاه علوم پزشکی جهرم، جهرم، ایران.

6 دانشجوی پزشکی، کمیته تحقیقات دانشجویی، دانشکده پزشکی، دانشگاه علوم پزشکی جهرم، جهرم، ایران.

7 استادیار گروه بیهوشی، دانشکده پزشکی، دانشگاه علوم پزشکی شیراز، شیراز، ایران.

چکیده

مقدمه: همه‌گیری کووید-19 زندگی مردم جهان را به شدت تحت تأثیر قرار داده است. دوره­های استرس و ناراحتی روانی ناشی از بروز این پاندمی می­تواند بر چرخه قاعدگی زنان تأثیر بگذارد. کووید-19 بر سلامت باروری زنان تأثیر قابل توجهی گذاشته است. مطالعه مرور روایتی حاضر با هدف بررسی تأثیر ویروس کرونا بر جنبه­های مختلف هر بخش این محور و رابطه آن با سلامت زنان با در نظر گرفتن محور هیپوتالاموس- هیپوفیز- تخمدان انجام شد.
روش‌کار: در این مطالعه مرور روایتی، پایگاه‌های اطلاعاتی PubMed، Scopus و Embase با استفاده از کلمات کلیدی سیستم باروری زنان، هیپوتالاموس، هیپوفیز و تخمدان و کلیدواژه‌های لاتین COVID-19 و SARS-COV-2 در منابع آنلاین، با محدودیت زمانی از سال 2020 به بعد مورد جستجو قرار گرفتند. سپس مطالعات از نظر مفهومی و یافته­ها خلاصه گردید و در قالب تأثیر کرونا ویروس بر هیپوتالاموس، هیپوفیز و تخمدان دسته‌بندی و تفسیر گردید.
یافته‌ها: احتمال بالقوه دست‌اندازی عصبی توسط ویروس کرونا، تأثیر مستقیم آن را از شروع تا پایان این محور ممکن می­سازد. با وجود اینکه مطالعات بیشتری تأثیر بیماری کرونا را بر نظم هورمون­های جنسی بدن زنان مبتلا به کرونا بررسی کرده‌اند، اکثر مطالعات در زمینه محور هیپوتالاموس و هیپوفیز بر اساس شبیه‌سازی­های ژنتیکی بوده است.
نتیجه‌گیری: ویروس کرونا می­تواند تأثیر گسترده‌ای بر تمام ارگان­های دخیل در سیستم باروری زنان داشته باشد. با گذشت زمان، درک ما نسبت به عوارض احتمالی این بیماری در باروری زنان افزایش خواهد یافت.

کلیدواژه‌ها

عنوان مقاله [English]

New coronavirus and hypothalamic-pituitary-ovarian axis in women: A narrative review

نویسندگان [English]

  • Athar RasekhJahromi 1
  • Majid Vatankhah 2
  • Mehrdad Malekshoar 2
  • Marzieh Haghbeen 3
  • Mojtaba Ghaedi 4
  • Navid Kalani 5
  • Naser Hatami 6
  • Seyed Ebrahim Sadeghi 7
1 Obstetrician and Gynecologist, Women's Health and Diseases Research Center, Faculty of Medicine, Jahrom University of medical sciences, Jahrom, Iran.
2 Associate Professor, Department of Anesthesiology, Fellowship of Critical Care, Anesthesiology & Critical Care and Pain Management Research Center, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
3 Assistant Professor, Department of Surgery, Faculty of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran.
4 Assistant Professor, Department of Plastic Surgery, Faculty of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran.
5 Instructor, Department of Anesthesiology, Research Center for Social Determinants of Health, School of Nursing, Jahrom University of Medical Sciences, Jahrom, Iran.
6 Medical Student, Student Research Committee, Faculty of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran.
7 Assistant Professor, Department of Anesthesiology, Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
چکیده [English]

Introduction: The COVID-19 epidemic has severely affected the life of people around the world. Periods of stress and psychological distress caused by this pandemic can affect a woman's menstrual cycle. The COVID-19 pandemic has had a significant impact on women's reproductive health. This narrative review was performed with aim to evaluate the effect of coronavirus on different aspects of each part of this axis and its relationship with women's health considering hypothalamic-pituitary-ovarian axis.
Methods: In this narrative review study, the databases of Pubmed, Scopus, and Embase were searched using the keywords of "Female Reproductive System", "Hypothalamus", "Pituitary" and "Ovary" with the keywords of "COVID-19" and "SARS-COV-2" with a time limit from 2020 onwards. Then, the studies were summarized conceptually and the findings were categorized and interpreted in terms of the effect of coronavirus on the hypothalamus, pituitary gland, and ovary.
Results: The potential neuronal invasion by the coronavirus could had led to its direct effect from the beginning to the end of this axis. Although more studies have examined the effect of COVID-19 on the regulation of sex hormones in women with COVID-19, most studies on the hypothalamic and pituitary axis have been based on genetic simulations.
Conclusion: Coronavirus can have a wide impact on all organs involved in the female reproductive system. Over time, our understanding of the possible effects of this disease on female fertility will increase.

کلیدواژه‌ها [English]

  • Coronavirus
  • COVID-19
  • Estrogen
  • Progesterone
  • Women

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مجله زنان، مامایی و نازایی ایران
دوره 24، شماره 12
بهمن 1400
صفحه 124-131

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