ارتباط محیط جنینی با سن یائسگی: یک مطالعه مروری روایتی

نوع مقاله : مروری

نویسندگان

دانشجوی دکتری بهداشت باروری، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران.

چکیده

مقدمه: هنگامی که ذخیره فولیکول تخمدان که در دوره جنینی ایجاد شده، به میزان زیادی کاهش یابد، زنان وارد دوران یائسگی می‌شوند. شرایط نامطلوب رحمی ممکن است بر فولیکول‌های تخمدان و در نتیجه سن یائسگی تأثیر بگذارد. با توجه به پیامدهای گسترده یائسگی و اثرات آن بر زندگی زنان، مطالعه مروری حاضر با هدف بررسی ارتباط محیط جنینی با سن یائسگی انجام شد.
روش‌کار: در این مطالعه مروری، مقالات در پایگاه‌های اطلاعاتیScopus ،Science direct ،Pubmed ،Web of Science ،Uptodate ،Magiran  و SID بدون محدودیت زمانی و با محدودیت زبان انگلیسی و فارسی و با استفاده از کلیدواژه‌های یائسگی، وزن هنگام تولد، سن بارداری، قحطی، Menopause، Birth weight، Famine و Gestational Age مورد جستجو قرار گرفتند. یافته‌ها در 4 حیطه موضوعی (وزن هنگام تولد، دوقلویی، سن بارداری هنگام تولد و قرار گرفتن در معرض قحطی در دوران جنینی) مورد بررسی قرار گرفتند.
یافته‌ها: پس از بازیابی 3100 مقاله، نتایج 13 مقاله که دارای معیارهای ورود به مطالعه بودند، مورد بررسی قرار گرفت. در هیچ یک از مطالعات ارتباط آماری معنی‌داری بین وزن کم هنگام تولد، سن حاملگی و در معرض قحطی بودن در دوران جنینی با سن یائسگی گزارش نشده بود. دو مطالعه ارتباط بین وزن بالای هنگام تولد و سن زودتر یائسگی را گزارش کرده‌اند. اگرچه مطالعات در زمینه دوقلویی، ارتباط معنی‌داری بین وزن هنگام تولد و سن یائسگی نشان نداده‌اند، نشانه‌هایی وجود دارد که دوقلوهای دارای نارسایی زودرس تخمدان، یائسگی زودرس را تجربه می‌کنند.
نتیجه‌گیری: تغییرات در محیط جنینی ممکن است با سن یائسگی مرتبط باشد. از آنجایی‌که یائسگی زودرس منجر به کوتاه شدن طول عمر تولیدمثل و افزایش بیماری‌ها در زنان می‌شود، توصیه می‌شود برای بررسی تأثیرات زندگی جنینی بر سن یائسگی، مطالعات بیشتری در این زمینه انجام شود.

کلیدواژه‌ها

عنوان مقاله [English]

The relationship between fetal environment and menopausal age: A narrative review study

نویسندگان [English]

  • Marzie Reisi
  • Leila Asadi
PhD student of Reproductive Health, School of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran.
چکیده [English]

Introduction: When the follicle reserve, which is developed solely during the fetal period, is depleted, women enter menopause. Adverse uterine conditions can affect the ovarian follicles and thus the age of menopause. Considering the widespread consequences of menopause and its effects on women's life, this review study was performed with aim to investigate the association between the fetal environment and menopausal age.
Methods: In this review study, articles were searched in databases of Scopus, Science direct, Pubmed, Web of Science, Uptodate, Magiran, and SID without time limit and with English and Persian language limitations and using the keywords of menopause, birth weight, gestational age, famine. Findings were examined in 4 thematic areas (birth weight, twins, gestational age at birth and famine exposure in fetal life).
Results: After revising 3100 articles, the results of 13 articles which had inclusion criteria were reviewed. None of the studies reported statistically significant association between low birth weight, gestational age and risk of famine during pregnancy with menopausal age. Two studies have reported an association between high birth weight and earlier menopausal age. Although studies of twins have shown no significant association between birth weight and menopausal age in twins, there are indications that twins with primary ovarian insufficiency experience premature menopause.
Conclusion: The changes in fetal environment may be related to menopausal age. Since premature menopause leads to shorter reproductive life and increased disease in women, it is recommended that more studies be performed in this regard to investigate the effects of fetal life on menopausal age.

کلیدواژه‌ها [English]

  • Birth weight
  • Famine
  • Gestational Age
  • Menopause
  • Twins

مراجع

  1. Vellanki K, Hou S. Menopause in CKD. American Journal of Kidney Diseases 2018; 71(5):710-9.
  2. Mishra GD, Chung HF, Pandeya N, Dobson AJ, Jones L, Avis NE, et al. The InterLACE study: design, data harmonization and characteristics across 20 studies on women’s health. Maturitas 2016; 92:176-85.
  3. InterLACE Study Team. Variations in reproductive events across life: a pooled analysis of data from 505 147 women across 10 countries. Human Reproduction 2019; 34(5):881-93.
  4. Mishra GD, Chung HF, Cano A, Chedraui P, Goulis DG, Lopes P, et al. EMAS position statement: Predictors of premature and early natural menopause. Maturitas 2019; 123:82-8.
  5. van der Schouw YT, van der Graaf Y, Steyerberg EW, Eijkemans MJ, Banga JD. Age at menopause as a risk factor for cardiovascular mortality. The lancet 1996; 347(9003):714-8.
  6. Sowers MR, La Pietra MT. Menopause: its epidemiology and potential association with chronic diseases. Epidemiologic reviews 1995; 17(2):287-302.
  7. La Vecchia C, Brinton LA, McTiernan A. Menopause, hormone replacement therapy and cancer. Maturitas 2001; 39(2):97-115.
  8. Wise PM, Dubal DB, Wilson ME, Rau SW, Böttner M. Minireview: neuroprotective effects of estrogen—new insights into mechanisms of action. Endocrinology 2001; 142(3):969-73.
  9. Collaborative Group on Hormonal Factors in Breast Cancer. Breast cancer and hormone replacement therapy: collaborative reanalysis of data from 51 epidemiological studies of 52 705 women with breast cancer and 108 411 women without breast cancer. The Lancet 1997; 350(9084):1047-59.
  10. Collaborative Group on Hormonal Factors in Breast Cancer. Menarche, menopause, and breast cancer risk: individual participant meta-analysis, including 118 964 women with breast cancer from 117 epidemiological studies. The lancet oncology 2012; 13(11):1141-51.
  11. Mishra G, Hardy R, Kuh D. Are the effects of risk factors for timing of menopause modified by age? Results from a British birth cohort study. Menopause 2007; 14(4):717-24.
  12. Perry JR, Murray A, Day FR, Ong KK. Molecular insights into the aetiology of female reproductive ageing. Nature Reviews Endocrinology 2015; 11(12):725-34.
  13. van Asselt KM, Kok HS, Pearson PL, Dubas JS, Peeters PH, Te Velde ER, et al. Heritability of menopausal age in mothers and daughters. Fertility and sterility 2004; 82(5):1348-51.
  14. Kok HS, van Asselt KM, van der Schouw YT, Peeters PH, Wijmenga C. Genetic studies to identify genes underlying menopausal age. Human reproduction update 2005; 11(5):483-93.
  15. Ruth KS, Perry JR, Henley WE, Melzer D, Weedon MN, Murray A. Events in early life are associated with female reproductive ageing: a UK Biobank Study. Scientific reports 2016; 6(1):1-9.
  16. Gold EB, Bromberger J, Crawford S, Samuels S, Greendale GA, Harlow SD, et al. Factors associated with age at natural menopause in a multiethnic sample of midlife women. American journal of epidemiology 2001; 153(9):865-74.
  17. Mishra GD, Cooper R, Tom SE, Kuh D. Early life circumstances and their impact on menarche and menopause. Women’s Health 2009; 5(2):175-90.
  18. Esmaili H, Alimi R, Javanrouh N, Azizi H, Vahid Roudsari F. Age at menopause and associated factors in middle-aged women in Mashhad City, 2010-2011. Iran J Obstet Gynecol Infertil 2013; 15(36):1-7.
  19. Faddy MJ, Gosden RG. Ovary and ovulation: a model conforming the decline in follicle numbers to the age of menopause in women. Human reproduction 1996; 11(7):1484-6.
  20. Baker TG. A quantitative and cytological study of germ cells in human ovaries. Proceedings of the Royal Society of London. Series B. Biological Sciences 1963; 158(972):417-33.
  21. Wallace WH, Kelsey TW. Human ovarian reserve from conception to the menopause. PloS one 2010; 5(1):e8772.
  22. Bjelland EK, Gran JM, Hofvind S, Eskild A. The association of birthweight with age at natural menopause: a population study of women in Norway. International journal of epidemiology 2020; 49(2):528-36.
  23. Cresswell JL, Egger P, Fall CH, Osmond C, Fraser RB, Barker DJ. Is the age of menopause determined in-utero?. Early Human Development 1997; 49(2):143-8.
  24. Yarde F, Broekmans FJ, Van der Pal-de Bruin KM, Schönbeck Y, Te Velde ER, Stein AD, et al. Prenatal famine, birthweight, reproductive performance and age at menopause: the Dutch hunger winter families study. Human Reproduction 2013; 28(12):3328-36.
  25. Chan KA, Jazwiec PA, Gohir W, Petrik JJ, Sloboda DM. Maternal nutrient restriction impairs young adult offspring ovarian signaling resulting in reproductive dysfunction and follicle loss. Biology of reproduction 2018; 98(5):664-82.
  26. Jazwiec PA, Li X, Matushewski B, Richardson BS, Sloboda DM. Fetal growth restriction is associated with decreased number of ovarian follicles and impaired follicle growth in young adult guinea pig offspring. Reproductive Sciences 2019; 26(12):1557-67.
  27. Treloar SA, Sadrzadeh S, Do KA, Martin NG, Lambalk CB. Birth weight and age at menopause in Australian female twin pairs: exploration of the fetal origin hypothesis. Human Reproduction. 2000 Jan 1;15(1):55-9.
  28. Hardy R, Kuh D. Does early growth influence timing of the menopause? Evidence from a British birth cohort. Human reproduction 2002; 17(9):2474-9.
  29. Steiner AZ, D'Aloisio AA, DeRoo LA, Sandler DP, Baird DD. Association of intrauterine and early-life exposures with age at menopause in the Sister Study. American journal of epidemiology 2010; 172(2):140-8.
  30. Tom SE, Cooper R, Kuh D, Guralnik JM, Hardy R, Power C. Fetal environment and early age at natural menopause in a British birth cohort study. Human Reproduction 2010; 25(3):791-8.
  31. Webber L, Davies M, Anderson R, Bartlett J, Braat D, Cartwright B, et al. European Society for Human Reproduction and Embryology (ESHRE) Guideline Group on POI. ESHRE Guideline: management of women with premature ovarian insufficiency. Hum Reprod 2016; 31(5):926-37.
  32. Conway GS, Kaltsas G, Patel A, Davies MC, Jacobs HS. Characterization of idiopathic premature ovarian failure. Fertility and sterility 1996; 65(2):337-41.
  33. Nelson LM, Covington SN, Rebar RW. An update: spontaneous premature ovarian failure is not an early menopause. Fertility and sterility 2005; 83(5):1327-32.
  34. Baethge C, Goldbeck-Wood S, Mertens S. SANRA—a scale for the quality assessment of narrative review articles. Research integrity and peer review 2019; 4(1):1-7.
  35. Goldberg M, Tawfik H, Kline J, Michels KB, Wei Y, Cirillo P, et al. Body size at birth, early-life growth and the timing of the menopausal transition and natural menopause. Reproductive Toxicology 2020; 92:91-7.
  36. Gosden RG, Treloar SA, Martin NG, Cherkas LF, Spector TD, Faddy MJ, et al. Prevalence of premature ovarian failure in monozygotic and dizygotic twins. Human Reproduction 2007; 22(2):610-5.
  37. Sadrzadeh S, Painter RC, van Kasteren YM, Braat DD, Lambalk CB. Premature ovarian insufficiency and perinatal parameters: A retrospective case-control study. Maturitas 2017; 96:72-6.
  38. Elias SG, van Noord PA, Peeters PH, den Tonkelaar I, Grobbee DE. Caloric restriction reduces age at menopause: the effect of the 1944–1945 Dutch famine. Menopause 2003; 10(5):399-405.
  39. Scagy RF. Menopause and reproductive span in rural Niugini. Proceedings Of The Annual Symposium Of The Papua New Guinea Medical Society 1993; 126-44.
  40. Barker DJ, Osmond C, Winter PD, Margetts B, Simmonds SJ. Weight in infancy and death from ischaemic heart disease. The Lancet 1989; 334(8663):577-80.
  41. De Bruin JP, Nikkels PG, Bruinse HW, Van Haaften M, Looman CW, Te Velde ER. Morphometry of human ovaries in normal and growth-restricted fetuses. Early human development 2001; 60(3):179-92.
  42. De Bruin JP, Dorland M, Bruinse HW, Spliet W, Nikkels PG, Te Velde ER. Fetal growth retardation as a cause of impaired ovarian development. Early human development 1998; 51(1):39-46.
  43. Bernal AB, Vickers MH, Hampton MB, Poynton RA, Sloboda DM. Maternal undernutrition significantly impacts ovarian follicle number and increases ovarian oxidative stress in adult rat offspring. PLoS One 2010; 5(12):e15558.
  44. Chernoff N, Gage MI, Stoker TE, Cooper RL, Gilbert ME, Rogers EH. Reproductive effects of maternal and pre-weaning undernutrition in rat offspring: age at puberty, onset of female reproductive senescence and intergenerational pup growth and viability. Reproductive Toxicology 2009; 28(4):489-94.
  45. Guzman C, Cabrera R, Cardenas M, Larrea F, Nathanielsz PW, Zambrano E. Protein restriction during fetal and neonatal development in the rat alters reproductive function and accelerates reproductive ageing in female progeny. The Journal of physiology 2006; 572(1):97-108.
  46. Goldenberg RL, Culhane JF, Iams JD, Romero R. Epidemiology and causes of preterm birth. The lancet 2008; 371(9606):75-84.
  47. Pagliaro CL, Bühler KE, Ibidi SM, Limongi SC. Dietary transition difficulties in preterm infants: critical literature review☆. Jornal de pediatria 2016; 92:07-14.
  48. Huber A, Michael S, Feik K. Functional changes in the fetal and infantile endometrium. Archiv fur Gynakologie 1971; 211(4):583-94.
  49. Edinger AL, Thompson CB. Death by design: apoptosis, necrosis and autophagy. Current opinion in cell biology 2004; 16(6):663-9.
  50. Heijmans BT, Tobi EW, Stein AD, Putter H, Blauw GJ, Susser ES, et al. Persistent epigenetic differences associated with prenatal exposure to famine in humans. Proceedings of the National Academy of Sciences 2008; 105(44):17046-9.
  51. Entringer S, de Punder K, Buss C, Wadhwa PD. The fetal programming of telomere biology hypothesis: an update. Philosophical Transactions of the Royal Society B: Biological Sciences 2018; 373(1741):20170151.
  52. Diamanti-Kandarakis E, Papalou O, Kandaraki EA, Kassi G. Mechanisms in Endocrinology: Nutrition as a mediator of oxidative stress in metabolic and reproductive disorders in women. European journal of endocrinology 2016; 176(2):R79-99.
  53. Wong JM, Collins K. Telomere maintenance and disease. The Lancet 2003; 362(9388):983-8.
  54. Aiken CE, Tarry‐Adkins JL, Ozanne SE. Suboptimal nutrition in utero causes DNA damage and accelerated aging of the female reproductive tract. The FASEB Journal 2013; 27(10):3959-65.
  55. Tarry‐Adkins JL, Chen JH, Smith NS, Jones RH, Cherif H, Ozanne SE. Poor maternal nutrition followed by accelerated postnatal growth leads to telomere shortening and increased markers of cell senescence in rat islets. The FASEB Journal 2009; 23(5):1521-8.
  56. Tarry‐Adkins JL, Martin‐Gronert MS, Chen JH, Cripps RL, Ozanne SE. Maternal diet influences DNA damage, aortic telomere length, oxidative stress, and antioxidant defense capacity in rats. The FASEB Journal 2008; 22(6):2037-44.
  57. Butts S, Riethman H, Ratcliffe S, Shaunik A, Coutifaris C, Barnhart K. Correlation of telomere length and telomerase activity with occult ovarian insufficiency. The Journal of Clinical Endocrinology & Metabolism 2009; 94(12):4835-43.
مجله زنان، مامایی و نازایی ایران
دوره 24، شماره 8
مهر 1400
صفحه 84-94

فایل ها

هم رسانی

ارجاع به این مقاله

آمار