تأثیر زیره سبز بر شاخص‌های سندرم متابولیک زنان سنین باروری

نوع مقاله : اصیل پژوهشی

نویسندگان

1 دانشجوی کارشناسی ارشد مامایی، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی رفسنجان، رفسنجان، ایران.

2 استادیار گروه مامایی، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی رفسنجان، رفسنجان، ایران.

3 مربی گروه مامایی، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی رفسنجان، رفسنجان، ایران.

4 استادیار گروه داروسازی سنتی، دانشکده طب ایرانی، دانشگاه علوم پزشکی کرمان، کرمان، ایران.

5 استادیار گروه طب سنتی، دانشکده طب ایرانی، دانشگاه علوم پزشکی کرمان، کرمان، ایران.

چکیده

مقدمه: سندرم متابولیک، یک نگرانی در حال افزایش بهداشت عمومی در سراسر جهان است. نیاز مبرمی به مهار این سندرم با به­کارگیری روش­هایی با حداقل عوارض جانبی احساس می‌شود. از این رو مطالعه حاضر با هدف بررسی تأثیر زیره سبز بر شاخص­های سندرم متابولیک انجام شد.
روش‌کار: این مطالعه کارآزمایی بالینی سه‌سوکور در سال 1398 بر روی 66 نفر از زنان سنین باروری با وجود حداقل 3 شاخص سندرم متابولیک و مراجعه‌کننده به مراکز خدمات جامع سلامت شهرستان رفسنجان انجام شد. افراد به‌صورت در دسترس انتخاب و با روش تخصیص تصادفی در دو گروه دریافت‌کننده 500 میلی‌گرم زیره سبز و دارونما تقسیم شدند. قبل و بعد از 8 هفته مداخله، اندازه دور کمر، FBS، HDL و تری‌گلیسرید اندازه­گیری شدند. تجزیه و تحلیل داده‌ها با استفاده از نرم‌افزار آماری SPSS (نسخه 18) و آزمون‌های ﮐﻮﻟﻤﻮﮔﺮوف اسمیرنوف، تی مستقل، من‌ویتنی یو، تی زوجی و ویلکاکسون انجام شد. میزان p کمتر از 05/0 معنی‌دار در نظر گرفته شد.
یافته‌ها: میانگین دور کمر، TG، HDL و فشارخون سیستولیک قبل و بعد از مداخله در گروه زیره سبز اختلاف معناداری داشت (05/0p<). در گروه کنترل این تغییرات معنادار نبودند. میانگین FBS در گروه زیره سبز تغییر معناداری نداشت (739/0=p)، ولی در گروه کنترل میزان FBS افزایش یافته بود (004/0=p). میانگین فشارخون دیاستولیک در هر دو گروه بعد از مداخله کاهش معناداری داشت (05/0>p)، ولی در گروه زیره سبز این کاهش بیشتر بود (001/0>p).
نتیجه‌گیری: مصرف 500 میلی‌گرم زیره سبز 2 بار در روز می‌تواند بر بهبود شاخص‌های سندرم متابولیک در زنان سنین باروری مؤثر باشد.

کلیدواژه‌ها


عنوان مقاله [English]

The Effect of Cuminum Cyminum on the characteristics of metabolic syndrome in women of reproductive age

نویسندگان [English]

  • Shirin Mahmoudi 1
  • Marzieh Loripour 2
  • Shayesteh Esmaeilzadeh 3
  • Zarrin Sarhadinezhad 4
  • Hale Tajoddini 5
1 M.Sc. student of Midwifery, School of Nursing and Midwifery, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
2 Assistant Professor, Department of Midwifery, School of Nursing and Midwifery, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
3 Instructor, Department of Midwifery, School of Nursing and Midwifery, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
4 Assistant Professor, Department of Traditional Pharmacy, School of Persian Medicine, Kerman University of Medical Sciences, Kerman, Iran
5 Assistant Professor, Department of Traditional Medicine, School of Persian Medicine, Kerman University of Medical Sciences, Kerman, Iran
چکیده [English]

Introduction: Metabolic syndrome is a growing public health concern around the world and there is an urgent need to control it by using the methods with minimal side effects. Therefore, this study was performed with aim to evaluate the effect of cuminum cyminum on metabolic syndrome indicators.
Methods: This three-blind clinical trial study was performed in 2019 on 66 women of reproductive age who had at least three metabolic syndrome indicators and referred to the comprehensive health service centers of Rafsanjan city. The subjects were selected by convenience and randomly assigned to the two groups of receiving 500 mg of cuminum cyminum and placebo. Before and after 8 weeks of the intervention, waist circumference, FBS, HDL, and triglyceride were measured. Data were analyzed by SPSS software (version 18) and Kolmogorov-Smirnov, independent t-test, Mann-Whitney U, paired t-test and Wilcoxon tests. P<0.05 was considered statistically significant.
Results: The mean of waist circumference, TG, HDL, and systolic blood pressure before and after the intervention had significant difference in the cuminum cyminum group (P<0.05). These changes were not significant in the control group. The mean of FBS did not significantly change in the cumin group)P=0.739), but in the control group, the FBS level increased (p=0.004). The mean of diastolic blood pressure in both groups significantly decreased after the intervention (p<0.05), but the decrease was more in the cumin group (p<0.001).
Conclusion: Consumption of 500 mg of cuminum cyminum twice a day can improve the indicators of metabolic syndrome in women of reproductive age.

کلیدواژه‌ها [English]

  • Cuminum cyminum
  • metabolic syndrome
  • Women of reproductive age
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