نقش رادیکال‌های آزاد و آنتی‌اکسیدان‌ها در اختلالات باروری مردان و زنان: مقاله مروری

نوع مقاله : مروری

نویسندگان

1 کارشناس ارشد گروه زیست‌شناسی، دانشکده علوم پایه، دانشگاه ملایر، ملایر، ایران.

2 کارشناس ارشد گروه علوم تشریح، دانشکده پزشکی، دانشگاه علوم پزشکی اراک، اراک، ایران.

3 دکترای گروه علوم تشریح، دانشکده پزشکی، دانشگاه علوم پزشکی اراک، اراک، ایران. دکترای گروه علوم تشریح، مرکز تحقیقات سلولی و مولکولی، دانشکده پزشکی، دانشگاه علوم پزشکی اراک، اراک، ایران.

چکیده

مقدمه: رادیکال‌های آزاد بر اساس سطح فیزیولوژیکی خود در بدن نقش دوگانه ایفا می‌کنند و می‌توانند مفید یا مضر باشند. مطالعه مروری حاضر با هدف بررسی مکانیسم‌های سلولی و مولکولی استرس اکسیداتیو بر اسپرماتوژنز و اووژنز و نقش استفاده از آنتی‌اکسیدان‌ها در بهبود باروری در مردان و زنان انجام شد.
روش‌کار: در این مقاله مروری مطالب مرتبط با نقش رادیکال‌های آزاد و آنتی‌اکسیدان‌ها در اختلالات باروری مردان و زنان به زبان فارسی و انگلیسی در پایگاه‌های اطلاعاتی از جمله Elsevier، Scopus، Irandoc، SID،Iran medex، Pubmed، Google scholar، Science direct و Web of Science با استفاده از کلمات کلیدی رادیکال آزاد، ناباروری مردان، ناباروری زنان و آنتی‌اکسیدان بدون در نظر گرفتن بازه زمانی مورد جستجو قرار گرفتند. در نهایت 63 مقاله وارد مطالعه مروری حاضر شدند.
یافته‌ها: تولید بیش از حد رادیکال‌های آزاد در دستگاه تناسلی مردانه باعث آسیب بهDNA ، RNA و غشای اسپرم و در نهایت اختلال در فرآیند اسپرماتوژنز می‌گردد و در دستگاه تناسلی زنانه نیز باعث ایجاد اختلالاتی همانند نقص در تکامل و بلوغ اووسیت، رشد فولیکول و عملکرد جسم زرد می‌شود.
نتیجه‌گیری: بر اساس یافته‌های مطالعات قبلی، ممکن استمصرفآنتی‌اکسیدان‌ها موجب برطرف کردن آثار مضر رادیکال‌های آزاد تولید شده بر بارداری مردان و زنان شود.

کلیدواژه‌ها


عنوان مقاله [English]

The role of free radicals and antioxidants in male and female fertility disorders: review study

نویسندگان [English]

  • Nasrin Kheradmand 1
  • Zahra Nadi 2
  • Maryam Baazm 3
1 M.Sc. of Biology, School of Basic Sciences, Malayer University, Malayer, Iran.
2 M.Sc. of Anatomic Sciences, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran.
3 PhD, Department of Anatomic Sciences, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran. PhD, Department of Anatomic Sciences, Medical and Molecular Research Center, Faculty of Medicine, Arak University of Medical
چکیده [English]

Introduction: Free radicals play a double role in the body based on their physiological level and can be beneficial or harmful. This review study was performed with aim to evaluate the cellular and molecular mechanisms of oxidative stress on spermatogenesis and oogenesis and the role of using antioxidant in improving fertility in men and women.
Methods: In this review study, the issues related to the role of free radicals and antioxidants on male and female fertility disorders were searched in the Persian and English databases including: Elsevier, Scopus, Irandoc, SID, Iran medex, Sciencedirect, Pubmed, GoogleScholar and Web of Science using the keywords of free radicals, male infertility, female infertility, and antioxidants without any time limitation. Finally, 63 studies entered the review study.
Results: The excessive production of free radicals in the male reproductive system causes damage to DNA, RNA, and sperm membranes, and ultimately disrupts spermatogenesis. It also causes disorders in the female genital tract including defect in oocyte development and maturation, follicular growth and function of corpus luteum.
Conclusion: According the results of previous studies, using antioxidants may remove the harmful effects of free radicals on male and female fertility.

کلیدواژه‌ها [English]

  • Antioxidants
  • female infertility
  • Free radicals
  • Male Infertility
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