بررسی تأثیر کپسول خوراکی عصاره برگ ریحان بر افسردگی زنان یائسه: یک کارآزمایی بالینی تصادفی‌سازی شده

نوع مقاله : اصیل پژوهشی

نویسندگان

1 استادیار گروه مامایی، مرکز تحقیقات مراقبت‌های پرستاری و مامایی، دانشگاه علوم پزشکی مشهد، مشهد، ایران. مرکز تحقیقات مراقبت‌های پرستاری و مامایی، دانشگاه علوم پزشکی مشهد، مشهد، ایران

2 دانشجوی کارشناسی ارشد مامایی، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی مشهد، مشهد، ایران.

3 مربی گروه پرستاری داخلی جراحی، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی مشهد، مشهد، ایران.

4 استادیار گروه فارماکولوژی، مرکز تحقیقات فارماکولوژیک و گیاهان دارویی، دانشکده پزشکی، دانشگاه علوم پزشکی مشهد، مشهد، ایران

چکیده

مقدمه: زنان به‌دلیل تغییرات جسمانی و روانی دوران یائسگی، عوارض متعددی را تجربه می­کنند. یکی از مهم‌ترین این عوارض، بروز افسردگی است. با توجه به اثرات جانبی داروهای شیمیایی، امروزه استفاده از درمان‌های گیاهی مورد توجه زنان قرار گرفته است. مطالعه حاضر با هدف تعیین تأثیر کپسول خوراکی عصاره برگ ریحان بر افسردگی زنان یائسه انجام شد.
روش‌کار: این مطالعه کارآزمایی بالینی تصادفی دوگروهه سه‌سوکور در سال 99-1398 بر روی 60 زن یائسه مراجعه‌کننده به مراکز بهداشتی درمانی مشهد انجام شد. زنان واجد شرایط ورود به مطالعه به‌مدت یک ماه روزی یک عدد کپسول 500 میلی‌گرمی عصاره برگ ریحان یا دارونما را دریافت می‌کردند. بررسی افسردگی قبل و بعد از مداخله با ابزار DASS (نسخه 21) انجام شد. تجزیه و تحلیل داده‌ها با استفاده از نرم‌افزار SPSS (نسخه 21) و آزمون‌های تی مستقل، من‌ویتنی و ویلکاکسون صورت گرفت. میزان p کمتر از 05/0 معنی‌دار در نظر گرفته شد.
یافته‌ها: قبل از مداخله میانگین نمره افسردگی در گروه ریحان 3/6±8/8 و در گروه دارونما 3/6±6/8 بود که از نظر آماری تفاوت معنی‌داری نداشت و دو گروه همگن بودند (904/0=p). بعد از مداخله میانگین نمره افسردگی در گروه ریحان (3/5±9/5) به‌طور معناداری کمتر از گروه دارونما (2/6±2/9) بود (049/0=p). تفاوت نمره افسردگی بعد نسبت به قبل از مداخله در گروه ریحان 5/4±8/2 نمره کاهش و در گروه دارونما 4/2±6/0 نمره افزایش داشت که این تفاوت از نظر آماری معنی‌دار بود (001/0>p).
نتیجه‌گیری: مصرف کپسول عصاره برگ ریحان منجر به کاهش نمره افسردگی در زنان یائسه شد، بنابراین می‌تواند به‌عنوان یک گیاه دارویی برای کاهش افسردگی زنان در دوران یائسگی مورد استفاده قرار گیرد.

کلیدواژه‌ها

عنوان مقاله [English]

Effect of oral capsule of Ocimum basilicum leaf extract on depression in menopausal women: A randomized clinical trial

نویسندگان [English]

  • Fatemeh Zahra Karimi 1
  • Hamideh Hosseini 2
  • Seyed Reza Mazloom 3
  • Hassan Rakhshandeh 4
1 Assistant Professor, Department of Midwifery, Nursing and Midwifery Care Research Center, Mashhad University of Medical Sciences, Mashhad , Iran. Nursing and Midwifery Care Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
2 M.Sc. Student of Midwifery, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran.
3 Instructor, Department of Surgery Internal, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad , Iran.
4 Assistant Professor, Department of Pharmacology, Pharmacological and Medicinal Plants Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده [English]

Introduction: Women experience many complications due to the physical and psychological changes of menopause. One of the most important of these complications is depression. Due to the side effects of chemical drugs, the use of herbal remedies has been considered by women today. This study was performed with aim to determine the effect of oral capsule of ocimum basilicum leaf extract on depression in menopausal women.
Methods: This triple-blind two-group randomized clinical trial study was performed on 60 menopausal women referred to Mashhad health centers in 2019-2020. Women eligible for the study received one 500 mg capsule of ocimum basilicum leaf extract or placebo for one month. Depression was assessed before and after the intervention with DASS21 tool. Data were analyzed by SPSS software (version 21) and independent t-test, Mann-Whitney, Wilcoxon. P < 0.05 was considered statistically significant.
Results: Before the intervention, the mean score of depression in the ocimum basilicum group was 8.8± 6.3 and in the placebo group was 8.6 ±6.3, which was not statistically significant and the two groups were homogeneous (P = 0.904). After the intervention, the mean score of depression in the ocimum basilicum group (5.9± 5.3) was significantly lower than the placebo group (9.2 ± 6.2) (P = 0.049). The difference in the score of depression after the intervention compared to before the intervention decreased by 2.8 ± 4.5 in the ocimum basilicum group and increased by 0.6 ± 2.4 in the placebo group and this difference was statistically significant (P <0.001).
Conclusion: Consumption of basil leaf extract capsules led to decrease in depression score in menopausal women. Therefore, it can be used as medicinal plant to reduce depression in menopausal women.

کلیدواژه‌ها [English]

  • Depression
  • Iran
  • Menopause
  • Ocimum basilicum
  • Women

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مجله زنان، مامایی و نازایی ایران
دوره 24، شماره 2
اردیبهشت 1400
صفحه 50-58

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