تأثیر تمرینات ترکیبی (هوازی- پیلاتس) بر سطح سرمی اینترلوکین 10 و پلاکت خون زنان مبتلا به سرطان پستان

نوع مقاله : اصیل پژوهشی

نویسندگان

1 دانشیار گروه علوم ورزشی، دانشکده علوم تربیتی و روان‌شناسی، دانشگاه شهید مدنی آذربایجان، تبریز، ایران.

2 دانشیار گروه علوم ورزشی، دانشکده علوم پزشکی، دانشگاه علوم پزشکی تبریز، تبریز، ایران.

3 کارشناس ارشد فیزیولوژی ورزشی، دانشکده علوم تربیتی و روان‌شناسی، دانشگاه شهید مدنی آذربایجان، تبریز، ایران.

4 دانشجوی دکتری فیزیولوژی ورزشی، دانشکده تربیت بدنی و علوم ورزشی، دانشگاه تبریز، تبریز، ایران.

چکیده

مقدمه: تمرین­های ورزشی می­تواند از راه تنظیم و تعدیل سایتوکینی، نقش حمایتی در بهبود سرطان پستان ایفا کند. اینترلوکین-10، سایتوکینی ضدالتهابی و ضدتوموری است که نقش مهمی در روند بازداری رشد تومور دارد. مطالعه حاضر با هدف بررسی تأثیر 12 هفته تمرین ترکیبی (هوازی-پیلاتس) بر سطح سرمی اینترلوکین-10 و پلاکت­ خون زنان مبتلا به سرطان پستان انجام شد.
روش‌کار: این مطالعه تجربی در سال 1398 بر روی ۳۰ زن مبتلا به سرطان پستان که حداقل 6 ماه از عمل جراحی آنها گذشته بود، دوره شیمی‌درمانی را پشت سر گذارده و تحت درمان دارویی بودند، در دانشگاه شهید مدنی آذربایجان انجام شد. افراد به دو گروه تجربی و کنترل تقسیم شدند. گروه تجربی به‌مدت ۱۲ هفته و هر هفته 3 جلسه به فعالیت ورزشی (هوازی-پیلاتس) پرداختند. در این مدت، گروه کنترل در هیچ برنامه­ فعالیت ورزشی یا بدنی شرکت نکردند. نمونه‌های خونی آزمودنی‌ها در قبل و 48 ساعت بعد از اعمال مداخله تمرین جهت استخراج متغیر­ها اخذ شد. تجزیه و تحلیل داده­ها با استفاده از نرم‌افزار آماری SPSS (نسخه 20) و آزمون‌های تی همبسته و مستقل انجام شد. میزان p کمتر از 05/0 معنی‌دار در نظر گرفته شد.
یافته­ها: بر اساس نتایج آزمون تی همبسته، سطح سرمی اینترلوکین 10 (001/0=p) و تعداد پلاکت­ها خونی (041/0=p) آزمودنی­های گروه تجربی نسبت به پیش­آزمون پس از 12 هفته تمرین ترکیبی (هوازی-پیلاتس) افزایش معنی­داری داشت، در‌حالی‌که در گروه کنترل تغییر ات  آنها معنی داری نبود (05/0p>).
نتیجه­گیری: اجرای تمرینات ترکیبی (هوازی و پیلاتس) با بهبود وضعیت اینترلوکین 10 به‌عنوان یک سایتوکین ضد‌التهابی و ضد‌توموری می­تواند در بهبود وضعیت سلامتی زنان مبتلا به سرطان پستان مفید باشد. از این رو طراحی و اجرای چنین تمریناتی در این جمعیت، می­تواند بسیاری از مشکلات این عزیزان را رفع نماید.

کلیدواژه‌ها


عنوان مقاله [English]

Effect of combined exercises (aerobic-pilates) on the serum level of interleukin 10 and blood platelets in women with breast cancer

نویسندگان [English]

  • Bohlool Ghorbanian 1
  • Vahid Montazeri 2
  • Fahimeh Rostami 3
  • Tohid Khanvari 4
1 Associate Professor, Department of Exercise Sciences, School of Education Sciences and Psychology, Azarbaijan Shahid Madani University, Tabriz, Iran.
2 Associate Professor, Department of Exercise Sciences, School of Medical Science, Tabriz University of Medical Science, Tabriz, Iran.
3 M.Sc. of Exercise Physiology, School of Education Sciences and Psychology, Azarbaijan Shahid Madani University, Tabriz, Iran.
4 Ph.D. Student of Exercise Physiology, School of Education Sciences and Psychology, Tabriz University of Medical Science, Tabriz, Iran.
چکیده [English]

Introduction:Exercise can play a supportive role in the improvement of breast cancer by regulating and modulating cytokines. Interleukin 10 is an anti-inflammatory and anti-tumor cytokine that plays an important role in inhibiting tumor growth. This study was performed with aim to evaluate the effect of 12 weeks of combined exercise (aerobic_pilates) on the serum level of interleukin 10 and blood platelets in women with breast cancer.
Methods: This experimental study was performed on 30 women with breast cancer who had undergone at least 6 months of surgery and had received chemotherapy and were under treatment with medication in Azarbaijan Shahid Madani University in 2019. The subjects were divided into experimental and control groups. The experimental group performed 3 sessions of exercise each week (aerobic-pilates) for 12 weeks. During this time, the control group did not participate in any exercise or physical activity program. Blood samples were obtained before and 48 hours after exercise intervention to extract the variables. Data were analyzed by SPSS software (version 20) and independent and correlated t-test. P<0.05 was considered statistically significant.
Results: The results of correlated t-test showed that the serum level of interleukin 10 (P =0.001) and the number of blood platelets (P =0.041) significantly increased in the experimental group after 12 weeks of combined training (aerobic-Pilates) compared to the pre-test, while this change was not significant in the control group (p> 0.05).
Conclusion: Performing combined exercises (aerobic_Pilates) by improving the status of interleukin 10 as an anti-inflammatory and anti-tumor cytokine can be useful in improving the health status of women with breast cancer. Therefore, designing and performing such exercises in this population can solve many problems of these loved ones.

کلیدواژه‌ها [English]

  • Blood platelet
  • Breast Cancer
  • Combined exercise
  • interleukin 10
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