ارتباط مقاومت به انسولین با دریافت غذایی ویتامین‌های D و E در زنان PCOS بر اساس معیار روتردام

نوع مقاله : اصیل پژوهشی

نویسندگان

1 کارشناس ارشد مامایی، گروه بهداشت باروری و مامایی، دانشکده علوم پزشکی، دانشگاه تربیت مدرس، تهران، ایران.

2 استاد گروه مامایی و بهداشت باروری، دانشکده پزشکی، دانشگاه تربیت مدرس تهران، تهران، ایران.

3 استاد گروه آمار زیستی، دانشکده پزشکی، دانشگاه تربیت مدرس، تهران، تهران، ایران.

4 مربی گروه مامایی، دانشکده پرستاری و مامایی، دانشکده علوم پزشکی نیشابور، نیشابور، ایران.

چکیده

مقدمه: سندرم تخمدان پلی‌کیستیک، شایع‌ترین اختلال اندوکرین با زمینه استرس اکسیداتیو در زنان سنین باروری است. استرس اکسیداتیو یک عامل تأثیرگذار در ایجاد مقاومت به انسولین است. برخی عناصر غذایی با استرس اکسیداتیو در ارتباط است، لذا مطالعه حاضر با هدف تعیین ارتباط مقاومت به انسولین با دریافت غذایی ویتامین‌های D و E در زیرگروه‌های PCOS انجام شد.
روش‌کار: این مطالعه مورد- شاهدی در سال 95-1394 بر روی 151 زن مبتلا به PCOS که بر اساس معیار تشخیصی روتردام به 4 ‌گروه، 41=(H+P+O)A ، 33=(H+P) B، 40=(P+O) C، 37=(H+O) D و 31 زن در گروه شاهد انجام شد. دریافت روزانه ویتامین‌های D و E با پرسشنامه بسامد خوراک 168 آیتمی PPQ انجام شد. تشخیص مقاومت به انسولین، با شاخص HOMA (5/2Cut off >) صورت گرفت. تجزیه و تحلیل داده‌ها با استفاده از نرم‌افزار آماری SPSS (نسخه 22) و آزمون‌های کروسکال والیس، آنووای یک‌طرفه، کای اسکوئر و اسپیرمن انجام شد. میزان p کمتر از 05/0 معنی‌دار در نظر گرفته شد.
یافته‌ها: در زیر‌گروه‌های A، D و گروه شاهد، ارتباط منفی و معناداری بین شاخص مقاومت به انسولین HOMA با ویتامین D (به‌ترتیب 022/0=p، 049/0=p و 025/0=p) و ویتامین E (به‌ترتیب 036/0=p، 001/0=p و 001/0=p) مشاهده شد. در زیرگروه‌های B و C بین شاخص مقاومت به انسولین  HOMAبا هیچ‌یک از ویتامین‌های D و E ارتباط آماری معناداری مشاهده نشد (05/0p>).
نتیجه‌گیری: با توجه به وجود ارتباط بین مقاومت به انسولین با ویتامین‌های D و E در زیرگروه‌های PCOS، افزایش مصرف غذایی حاوی ویتامین‌های D و E در بهبود پارامترهای سلامتی این افراد پیشنهاد می‌شود.

کلیدواژه‌ها


عنوان مقاله [English]

Relationship between insulin resistance and dietary intake of vitamins D and E in women with PCOS based on Rotterdam criteria

نویسندگان [English]

  • Maryam Movahedinejad 1
  • Saeideh Ziaei 2
  • Anoushirvan Kazemnejad 3
  • Zahra Kamali 4
1 M.Sc. in Midwifery, Department of Midwifery and Reproductive Health, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
2 Professor, Department of Midwifery and Reproductive Health, Faculty of Medicine, Tarbiat Modares University, Tehran, Iran.
3 Professor, Department of Biostatistics, Faculty of Medicine, Tarbiat Modares University, Tehran, Iran.
4 Instructor, Department of Midwifery, School of Nursing and Midwifery, Neyshabur University of Medical Sciences, Neyshabur, Iran.
چکیده [English]

Introduction: Polycystic Ovary Syndrome (PCOS) is the most common endocrine disorder with oxidative stress in women of reproductive age. Oxidative stress is an important factor in the development of insulin resistance. Some nutrients are linked to oxidative stress. This study was performed with aim to determine the relationship between insulin resistance and dietary intake of vitamins D and E in PCOS subgroups.
Methods: This case-control study was performed in 2015-2016 on 151 women with PCOS who were divided into four groups according to Rotterdam diagnostic criteria (D (H+O) = 37, C (P+O) = 40, B (H+P)= 33, A (H+P+O) = 41 and 31 women in the control group). Daily intake of vitamin D and vitamin E was assessed using a 168 items PPQ food frequency questionnaire. Insulin resistance was diagnosed with HOMA index (Cut off> 2.5). Data were analyzed by SPSS software (version 22) and Kruskal-Wallis, one-way ANOVA, Chi-square and Spearman tests. P<0.05 was considered statistically significant.
Results: In the subgroups of A, D and control group, a significant negative relationship was observed between HOMA insulin resistance index with vitamin D (P = 0.022), (P = 0.049) and (P = 0.025), respectively and with vitamin E (P = 0.036), (P = 0.001) and (P = 0.001), respectively. In the subgroups of B and C, no relationship between HOMA insulin resistance index with vitamin D and vitamin E (P> 0.05).
Conclusion: Due to the relationship between insulin resistance and vitamins D and E in PCOS subtypes, it is recommended to increase the intake of vitamins D and E to improve health parameters in PCOS subjects.

کلیدواژه‌ها [English]

  • insulin resistance
  • Polycystic ovary syndrome
  • Vitamin D and E
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