مجله زنان، مامایی و نازایی ایران

مجله زنان، مامایی و نازایی ایران

بررسی تأثیر کپسول خوراکی رازیانه بر علائم جسمانی ناشی از یائسگی زنان

نوع مقاله : اصیل پژوهشی

نویسندگان
پروین گلزاره 1
روجا رحیمی 2
فاطمه رحیمی کیان 3
رضا بخردی 4
عباس مهران 5
1 کارشناس ارشد مامایی، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی تهران، تهران، ایران.
2 استادیار گروه داروسازی سنتی، دانشکده طب سنتی، دانشگاه علوم پزشکی تهران، تهران، ایران.
3 مربی گروه آموزشی بهداشت باروری، بارداری و زایمان، مرکز تحقیقات مراقبت‌های پرستاری و مامایی‌، دانشگاه علوم پزشکی تهران، تهران، ایران.
4 دکترای حرفه‌ای پزشکی، واحد تحقیق و توسعه شرکت داروسازی باریج اسانس، کاشان، ایران.
5 کارشناس ارشد آمار حیاتی، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی تهران، تهران، ایران.
10.22038/ijogi.2017.9954
چکیده
مقدمه: علائم یائسگی می­تواند اثرات زیانباری بر زندگی زنان گذاشته و کیفیت زندگی آنان را تحت تأثیر قرار دهد. بسیاری از زنان یائسه جهت سازگاری با علائم یائسگی، به درمان­های طب مکمل چون گیاه درمانی و استفاده از فیتواستروژن­ها روی آورده‌اند. مطالعه حاضر با هدف ارزیابی تأثیر رازیانه به عنوان یک فیتواستروژن در درمان علائم جسمانی یائسگی انجام شد.
روش‌کار: این مطالعه کارآزمایی بالینی تصادفی شده در سال 1395 بر روی 90 زن یائسه 60-45 ساله در تهران انجام شد. افراد به طور تصادفی به دو گروه رازیانه و دارونما تقسیم شدند. زنان در گروه رازیانه به مدت 8 هفته روزانه 2 کپسول نرم 100 میلی‌گرمی رازیانه و در گروه دارونما 2 کپسول نرم 100 میلی‌گرمی روغن آفتابگردان را دریافت کردند. علائم جسمانی یائسگی به وسیله بخش جسمانی پرسشنامه معیار سنجش یائسگی اندازه‌گیری شد. تجزیه و تحلیل داده­ها با استفاده از نرم‌افزار آماری SPSS (نسخه 14) و آزمون­های تی مستقل و تی زوجی انجام شد. میزان p کمتر از 05/0 معنی‌دار در نظر گرفته شد.
یافته‌ها: قبل از مداخله،دو گروه از نظر علائم جسمانی یائسگی مشابه بودند، اما پس از 8 هفته مداخله، بر اساس آزمون آماری تی زوجی، در گروه رازیانه، علائم جسمانی یائسگی بعد از مداخله در مقایسه با قبل از مداخله از نظر آماری کاهش معنی­داری یافت (001/0p<)، اما در گروه دارونما علائم بعد از مداخله با قبل از مداخله اختلاف آماری معنی‌داری نداشت (05/0<p).
نتیجه‌گیری: رازیانه بدون هیچ عارضه جدی در کاهش علائم جسمانی یائسگی مؤثر است. تحقیقات بیشتر برای قطعی شدن نتایج حاصل از این مطالعه مورد نیاز است.
کلیدواژه‌ها
رازیانه
علائم جسمانی
یائسگی

عنوان مقاله English

The effect of fennel oral capsules on physical symptoms caused by menopause in women

نویسندگان English

Parvin Golzareh 1
Roja Rahimi 2
Fatemeh Rahimikian 3
Reza Bekhradi 4
Abbas Mehran 5
1 M.Sc. of Midwifery, School of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, Iran.
2 Assistant professor, Department of Traditional Pharmacy, School of Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran.
3 Instructor, Department of Reproductive Health, Pregnancy and Delivery, Nursing and Midwifery Care Research Center, Tehran University of Medical Sciences, Tehran, Iran.
4 MD, Barij Essen Pharmaceutical Company Research and development unit, Kashan, Iran.
5 M.Sc. of Biostatistics, School of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, Iran.
چکیده English

Introduction: Menopause symptoms can have harmful effects on women's life and affect their quality of life. Most of post-menopausal women have turned to complementary medicine therapies such as herbal therapy and the use of phytoestrogens for compatibility with menopausal symptoms. This study was performed with aim to assess the effect of fennel as a phytoestrogen in treatment of menopausal physical symptoms.
Methods: This clinical randomized trial was performed in 2016 on 90 post-menopause women aged 45-60 years in Tehran. The subjects were randomly assigned to two groups of fennel and placebo. Women in fennel group received 8 weeks of treatment with daily two 100mg fennel soft capsules and in placebo group with two 100 mg sun flower oil capsules. The menopausal physical symptoms were measured by the physical part of Menopause Rating Scale (MRS) questionnaire. Data were analyzed by SPSS software (version 14) and Independent t-test and Paired t-test. P<0.05 was considered significant.
Results: The two groups were similar in menopausal physical symptoms before the intervention. But, after 8 weeks of the intervention, Independent t-test showed that menopausal physical symptoms after the intervention were significantly decreased compared to before the intervention (P<0.001), but in placebo group, menopausal physical symptoms after the intervention were not significantly different with before the intervention (P>0.05).
Conclusion: Fennel is effective in reducing menopausal physical symptoms without any serious side effect. More researches are needed to definite the results of this study.

کلیدواژه‌ها English

Fennel
Menopause
Physical symptoms
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مجله زنان، مامایی و نازایی ایران
دوره 20، شماره 9
آذر 1396
صفحه 41-48