مقایسه اثر موضعی روغن زنجبیل با زنجبیل خوراکی بر علائم همراه دیسمنوره اولیه: کارآزمایی بالینی

نوع مقاله : اصیل پژوهشی

نویسندگان

1 متخصص طب سنتی، دانشکده طب سنتی، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران.

2 استادیار گروه داروسازی سنتی، مرکز تحقیقات طب سنتی و مفردات پزشکی، دانشکده طب سنتی، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران.

3 استادیار مؤسسه تحقیقات طب اسلامی و مکمل، دانشگاه علوم پزشکی ایران، تهران، ایران.

4 استادیار گروه طب سنتی، دانشکده طب سنتی، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران.

چکیده

مقدمه: دیسمنوره ‌اولیه در همراهی با علائم‌ همراه، عواقب فراوانی به‌دنبال ‌‌دارد. از دیدگاه طب ‌سنتی ‌ایران و مطالعات، زنجبیل خوراکی و موضعی بر درد دیسمنوره ‌اولیه مؤثر هستند، لذا مطالعه حاضر با هدف بررسی اثر خوراکی کپسول زنجبیل و اثر موضعی روغن زنجبیل تهیه شده به روش ماسراسیون بر علائم همراه دیسمنوره و مقایسه اثرات آن‌ها انجام شد.
روش‌کار‌: این مطالعه کارآزمایی ‌بالینی یک‌سوکور در سال 96-1395 بر روی 70 دانشجوی مبتلا به دیسمنوره متوسط و شدید و ساکن در خوابگاه دانشگاه علوم پزشکی شهید بهشتی تهران انجام شد. علائم همراه دیسمنوره در این دانشجویان در سیکل اول بر اساس معیار چند بُعدی کلامی ارزیابی ‌شد، سپس بیماران به‌طور تصادفی به دو گروه خوراکی و موضعی تقسیم‌ شدند و طی سه سیکل بعدی دارو را از دو روز قبل از شروع قاعدگی تا روز سوم قاعدگی دریافت ‌کردند. گروه خوراکی هر 6 ساعت یک عدد کپسول زنجبیل مصرف ‌کردند و گروه موضعی هر 6 ساعت پنج قطره روغن زنجبیل زیر شکم مالیدند. علائم همراه دیسمنوره در هر سیکل بر اساس معیار چند بُعدی ‌کلامی ارزیابی و سپس مقایسه ‌شد.تجزیه و تحلیل داده‌ها با استفاده از نرم‌افزار آماری SPSS ‌(نسخه 17) و آزمون‌های من‌ویتنی و ویلکاکسون انجام شد. میزان p کمتر از 05/0 معنادار در نظر گرفته ‌شد.
یافته‌ها: خستگی، بی‌حالی، نفخ، سردرد، کمردرد و گرفتگی‌ عضلات ‌پا در هر دو ﮔﺮوه نسبت به قبل از مداخله ﻛﺎﻫﺶ یافت (05/0p<). تهوع، استفراغ و اسهال در گروه خوراکی و تغییر حالات ‌عصبی و پادرد در گروه موضعی بعد از مداخله کاهش ‌یافت (05/0p<). عارضه جانبی فقط در گروه خوراکی مشاهده ‌شد (60%).
نتیجه‌گیری: هر دو فرم زنجبیل موجب کاهش مشابه علائم عمومی و عصبی همراه دیسمنوره ‌شدند و فرم خوراکی تعداد بیشتری از علائم گوارشی و فرم موضعی تعداد بیشتری از علائم عضلانی- اسکلتی همراه دیسمنوره را کاهش‌ داد. همچنین از آنجا که فرم موضعی بهتر از فرم خوراکی توسط بیماران تحمل شد، به‌نظر می‌رسد مالیدن موضعی روغن زنجبیل انتخاب بهتری در کاهش علائم عمومی و عصبی همراه دیسمنوره ‌باشد.

کلیدواژه‌ها

عنوان مقاله [English]

Comparison of local effects of ginger oil with oral ginger on associated symptoms of primary dysmenorrhea: randomized clinical trial

نویسندگان [English]

  • Pantea Shirooye 1
  • Maryam Hamzeloo-Moghadam 2
  • Fataneh Hashem-Dabaghian 3
  • Roshanak Mokaberinejad 4
1 PhD of Traditional Medicine, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2 Assistant Professor, Department of Traditional Pharmacy, Traditional Medicine and Materia Medica Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
3 Assistant Professor, Research Institute for Islamic and Complementary Medicine, Iran University of Medical Sciences, Tehran, Iran.
4 Assistant Professor, Department of Traditional Medicine, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
چکیده [English]

Introduction: Primary dysmenorrhea along with associated symptoms is followed by many consequences. According to Iranian Traditional Medicine point of view and the studies, oral and topical ginger are effective on primary dysmenorrhea. So this study was performed with aim to evaluate the effect of oral ginger capsule and topical ginger oil which are prepared by Maceration method on the associated symptoms of dysmenorrhea and comparing their effects.
Methods: This single-blind randomized clinical trial was performed on 70 students with moderate and severe dysmenorrhea who were resident in dormitory of Tehran Shahid Beheshti University of Medical Sciences in 2016-2017. The associated symptoms of dysmenorrhea in these students were assessed with verbal multidimensional scoring system in first cycle. Then, the patients were randomized into two groups of oral and topical and they received drugs two days before the start of menstruation until first three days of menstruation over next three cycles. The oral group received one ginger capsule every 6 hours and the topical group applied 5 drops of ginger oil below the abdomen every 6 hours. The associated symptoms of dysmenorrhea were assessed and compared in each cycle based on verbal multidimensional scoring system. Data were analyzed by SPSS software (version 17) and Mann-Whitney and Wilcoxon tests. P< 0.05 was considered significant.
Results: Fatigue, bloat, headache, backache and leg cramps decreased in both groups compared to before the intervention (p<0.05). Nausea, vomiting and diarrhea decreased in oral group, and mood’s changes and leg pain decreased in topical group (p<0.05) after the intervention. Side effects were observed only in oral group (60%).
Conclusion: Both forms of ginger reduced general and neurological symptoms of dysmenorrhea; the oral form decreased more gastrointestinal symptoms of dysmenorrhea and topical form decreased more musculoskeletal symptoms of dysmenorrhea. In addition, since topical form was better tolerated by patients, so it seems that topical ginger oil is a better choice for reducing the general and neurological symptoms of dysmenorrhea.

کلیدواژه‌ها [English]

  • Associated symptoms of dysmenorrhea
  • Dysmenorrhea
  • ginger
  • Ginger oil
  • Iranian Traditional Medicine

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مجله زنان، مامایی و نازایی ایران
دوره 20، شماره 8
آبان 1396
صفحه 61-69

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