تأثیر هشت هفته تمرین هوازی بر غلظت پاراتورمون، استروژن و آلکالین فسفاتاز سرمی زنان چاق مبتلا به یائسگی زودرس

نوع مقاله : اصیل پژوهشی

نویسندگان

1 دانشیار گروه فیزیولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه فردوسی مشهد، مشهد، ایران.

2 استاد گروه فیزیولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه فردوسی مشهد، مشهد، ایران.

3 دانشجوی دکترای تخصصی فیزیولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه فردوسی مشهد، مشهد، ایران.

چکیده

مقدمه: پوکی استخوان، شایع‌ترین بیماری متابولیک استخوانی بوده که می‌تواند منجر به شکستگی‌های خطرناک شود. در این بیماری توده استخوانی تحلیل یافته و شکستگی به راحتی اتفاق می‌افتد. مطالعه حاضر با هدف تأثیر هشت هفته تمرین هوازی بر غلظت هورمون پاراتورمون، استروژن و آلکالین فسفاتاز سرمی زنان مبتلا به یائسگی زودرس انجام شد.
روش‌کار: این مطالعه نیمه تجربی در سال 1393 بر روی 21 زن مبتلا به یائسگی زودرس با دامنه سنی 45-35 سال انجام شد. آزمودنی‌ها به صورت تصادفی در دو گروه تجربی و کنترل قرار گرفتند. برنامه تمرین هوازی شامل 8 هفته، هر هفته 3 جلسه و هر جلسه به مدت 45 تا60 دقیقه با شدتی معادل 65% تا 75% حداکثر ضربان قلب ذخیره اجرا شد. 24 ساعت پیش از اولین جلسه تمرین و 48 ساعت بعد از آخرین جلسه تمرینی در پایان هفته هشتم، مقادیر هورمون پاراتورمون، استروژن و برخی نشانگرهای متابولیزم استخوان سرمی با استفاده از روش رادیوایمونواسی (RIA) و الایزا در حالت 12 ساعت ناشتایی ارزیابی شد. تجزیه و تحلیل داده‌ها با استفاده از نرم‌افزار آماری SPSS (نسخه 16) و آزمون‌های تی دانشجویی و تحلیل کوواریانس انجام شد. میزان p کمتر از 05/0 معنی‌دار در نظر گرفته شد.
یافته­ها: هشت هفته تمرین هوازی منجر به افزایش معنی‌دار مقادیر کلسیم (001/0=p)، فسفر (001/0=p)، استروژن (001/0=p) و پاراتورمون (001/0=p) در گروه تمرین هوازی شد، در صورتی که تغییر معنی‌داری در مقادیر الکالین فسفاتاز در پایان دوره مشاهده نشد (92/0=p).
نتیجه‌گیری: هشت هفته تمرین هوازی با شدت 65% تا 75% حداکثر ضربان قلب ذخیره منجر به افزایش معنی‌دار در مقادیر کلسیم، فسفر، استروژن و پاراتورمون در زنان مبتلا به یائسگی زودرس شد. در کل می‌توان نتیجه گرفت که اجرای فعالیت بدنی منظم منجر به افزایش تراکم استخوان‌ها و کاهش خطر شکستگی در زنان یائسه زودرس می‌شود.

کلیدواژه‌ها

عنوان مقاله [English]

Effect of eight Weeks Aerobic Training on Serum parathormone, estrogen and Alkaline phosphatase concentration in obese women with premature menopause

نویسندگان [English]

  • Mehrdad Fathi 1
  • Seyed Reza Attarzadeh Hosseini 2
  • Somayeh khair abadi 3
  • Keyvan Hejazi 3
1 Associate professor, Department of Sport Physiology, Faculty of Sport Sciences, Ferdowsi University of Mashhad, Mashhad, Iran.
2 Professor, Department of Sport Physiology, Faculty of Sport Sciences, Ferdowsi University of Mashhad, Mashhad, Iran.
3 PhD Student in Sport Physiology, Faculty of Sport Sciences, Ferdowsi University of Mashhad, Mashhad, Iran.
چکیده [English]

Introduction: Osteoporosis is the most common metabolic bone disease that could causes many dangerous fractures. In this condition bone mass reduces, so fractures can easily occur. The aim of this study was assessing the effect of eight weeks of aerobic training on serum parathormone, estrogen and Alkaline phosphatase concentration in Women with premature menopause.
Methods: Methods: In this study semi-experimental study, in 2014, 21 women with premature menopause (age 35-45 year, body mass index (BMI>30 kg/m2), height: 161.19±2.64 and weight 83.97±1.98) were selected by convenience sampling method and they were randomly divided into two groups experimental (n=10) and control (n=11). The subject in experimental group had an aerobic training program for eight week (3 sessions in week, each session 45-60 minutes, the intensity of exercise was 65 to 75 percent of maximum heart rate). Blood samples were taken from the subjects’ 24 hours before the first session and 48 hours after the last training session at end of eight week in order to measure factors such as (parathyroid hormone (PTH), estrogen and some bone metabolism) by using a radioimmunoassay (RIA) and ELISA method in 12 hours of fasting. Then Data for inter and between group comparison, paired and ANCOVA test were used (significance level p<0.05).
Results: The result of this study show that, eight weeks aerobic training lead to a significant increase in mean values of serum calcium (p=0.001), phosphor (p=0.001), estrogen (p=0.001), parathormone (p=0.001) in aerobic training group; while, the amount of alkaline phosphatase did not change at the end of period (p=0.92).
Conclusion: Eight weeks aerobic training with 65 to 75 percent of maximum heart rate intensity was efficient in increasing of serum calcium, phosphor, estrogen, parathormone in women with premature menopause. It is concluded that regular training can help to increase bone density and reduces the risk of fractures in women with premature menopause.

کلیدواژه‌ها [English]

  • Parathormone
  • Estrogen
  • Alkaline phosphatase
  • Calcium
  • Aerobic training

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مجله زنان، مامایی و نازایی ایران
دوره 20، شماره 7
مهر 1396
صفحه 8-17

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