تأثیر گیاه رازک بر علائم وازوموتور یائسگی: یک مطالعه مرور سیستماتیک و متاآنالیز

نوع مقاله : مروری

نویسندگان

1 دانشجوی دکترای تخصصی، کمیته پژوهشی دانشجویان، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران.

2 دکترای تخصصی بهداشت باروری، مرکز تحقیقات مراقبت‌های مادر و کودک، دانشگاه علوم پزشکی هرمزگان، بندرعباس، ایران.

چکیده

مقدمه: علائم وازوموتور یکی از شایع‌ترین مشکلات زنان در دوران یائسگی است و ممکن است کیفیت زندگی زنان را تحت تأثیر قرار دهد. گیاه رازک حاوی ترکیبات فیتواستروژنی قوی می‌باشد که در کاهش علائم یائسگی مؤثر است. مطالعه مرور سیستماتیک و متاآنالیز حاضر با هدف بررسی تأثیر گیاه رازک بر علائم وازوموتور یائسگی انجام شد.
روش‌کار: در این مطالعه مرور سیستماتیک پایگاه‌های اطلاعاتی شامل MEDLINE، EMBASE، ProQuest،Web of Science ، Scopus،Uptodate ،The Cochrane Central Register of Controlled Trials ، PsycINFO، Google scholar و (CINAHL (EBSCO، با استفاده از کلمات کلیدی "یائسگی"، "رازک"، "گرگرفتگی" و "علائم وازوموتور" جستجو شدند و تمام کارآزمایی‌های بالینی از سال 2000 میلادی تا پایان دسامبر سال 2015 وارد مطالعه شدند. هیچ محدودیتی در زبان انتشار مقالات وجود نداشت. در نهایت تعداد 4 مقاله استخراج و وارد مطالعه شد. تجزیه و تحلیل داده‌ها با استفاده از نرم‌افزار STATA (نسخه 10) انجام شد. از آزمون Egger برای سوگیری انتشارات و از شاخص I2 و کای اسکوئر جهت بررسی همگنی بین مطالعات استفاده شد. جهت بررسی معنی‌داری تفاوت میانگین‌ها از Z-value و P-value استفاده شد.
یافته‌ها: از 340 مقاله در بررسی اولیه، در نهایت 4 مقاله وارد مطالعه شدند. ترکیب داده‌های مطالعات مختلف بر مبنای مدل تصادفی نشان داد گیاه رازک باعث بهبود علائم وازموتور یائسگی می‌شود و تعداد و شدت دوره‌های گرگرفتگی و تعریق شبانه را کاهش می‌دهد (05/0>p).
نتیجه‌گیری: گیاه رازک می‌تواند به عنوان یک درمان جایگزین مناسب در بهبود علائم وازوموتور یائسگی در نظر گرفته شود.

کلیدواژه‌ها

عنوان مقاله [English]

The effects of Humulus Lupulus L.)Hops) on Menopausal Vasomotor Symptoms: A Systematic Review and Meta- analysis

نویسندگان [English]

  • Fatemeh Abdi 1
  • Nasibeh Roozbeh 2
1 PhD student, Student Research Committee, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2 PhD in Reproductive Health, Mother and Child Welfare Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
چکیده [English]

Introduction: Vasomotor symptom is one of the most commonly problems of women during menopause and can negatively affect women’s quality of life. Humulus Lupulus L.) Hops) has powerful Phytoestrogenic compounds which are effective in the alleviation of menopausal symptoms. This systematic review and meta-analysis study was performed with aim to evaluate the effects of hops on vasomotor symptoms of menopause.
Methods: In this systematic review, databases of Medline, Embase, ProQuest, Web of Science, the Cochrane Central Register of Controlled Trials, PsycINFO, Scopus, Uptodate, Google Scholar, and CINAHL (EBSCO) were searched using the keywords of “menopause”, “hops”, “hot flash”, and “vasomotor symptoms” and all clinical trials published between 2000 to the end of December 2015 were included in the study. No limitation was imposed on the papers’ language. Finally, four articles were extracted and evaluated. Data was analyzed by Stata software (version 10). Publication bias was assessed by Egger tests and heterogeneity was assessed by chi-square and I2 index. Z-value and P-value were used for evaluation of the significance of mean differences.
Results: Among 340 initially assessed papers, finally, 4 articles were entered to the study. Combining data from different studies based on random model indicated that hop alleviated vasomotor symptoms of menopause and reduced the frequency and duration of hot flushes and night sweats (P<0.05).
Conclusion: Hops can be used as an alternative treatment in the management of vasomotor symptoms of menopause.

کلیدواژه‌ها [English]

  • Hops
  • hot flashes
  • Menopause
  • Vasomotor

مراجع

  1. Yazdkhasti M, Simbar M, Abdi F. Empowerment and coping strategies in menopause women: a review. Iran Red Crescent Med J 2015; 17(3):e18944.
  2. Nosek M, Kennedy HP, Gudmundsdottir M. Distress during the menopause transition. Sage Open 2012; 2(3):1-10.
  3. Harris MT. Menopause: the need for a paradigm shift from disease to women's health. [PhD Thesis]. Lismore, NSW: Southern Cross University; 2013.
  4. Abdi F, Mobedi H, Mosaffa N, Dolatian M, Ramezani Tehrani F. Effects of hormone replacement therapy on immunological factors in the postmenopausal period. Climacteric 2016; 19(3):234-9.
  5. Rubinstein H. The meanings of menopause: identifying the bio-psycho-social predictors of the propensity for treatment at menopause. [PhD Thesis]. Cambridge, UK: University of Cambridge; 2013.
  6. Al-Safi ZA, Santoro N. Menopausal hormone therapy and menopausal symptoms. Fertil Steril 2014; 101(4):905-15.
  7. Rotem M, Kushnir T, Levine R, Ehrenfeld M. A Psycho‐educational program for improving women's attitudes and coping with menopause symptoms. J Obstet Gynecol Neonatal Nurs 2005; 34(2):233-40.
  8. Crowe B. The effects of yoga participation on symptoms associated with menopause: a mixed methods study. [PhD Thesis]. Brandi Crowe: Clemson University; 2014.
  9. Abdi F, Mobedi H, Mosaffa N, Dolatian M, Ramezani Tehrani F. Hormone therapy for relieving postmenopausal vasomotor symptoms: a systematic review. Arch Iran Med 2016; 19(2):141-6.
  10. Reid RL, Blake J, Abramson B, Khan A, Senikas V, Fortier M. Menopause and osteoporosis update 2009. J Obstet Gynaecol Can 2009; 31(1):S1-3.
  11. Theroux R. Women's decision making during the menopausal transition. J Am Acad Nurse Pract 2010; 22(11):612-21.
  12. Gurney EP, Nachtigall MJ, Nachtigall LE, Naftolin F. The women's health initiative trial and related studies: 10 years later: a clinician's view. J Steroid Biochem Mol Biol 2014; 142:4-11.
  13. Mascitelli L, Goldstein MR. Menopause, estrogen, statins, and the immune system. Maturitas. 2011; 68(2):197.
  14. Teekachunhatean S, Mattawanon N, Khunamornpong S. Short-term isoflavone intervention in the treatment of severe vasomotor symptoms after surgical menopause: a case report and literature review. Case Rep Obstet Gynecol 2015; 2015:962740.
  15. Moreira AC, Silva AM, Santos MS, Sardao VA. Phytoestrogens as alternative hormone replacement therapy in menopause: What is real, what is unknown. J Steroid Biochem Mol Biol 2014; 143:61-71.
  16. Van Cleemput M, Cattoor K, De Bosscher K, Haegeman G, De Keukeleire D, Heyerick A. Hop (Humulus lupulus)-derived bitter acids as multipotent bioactive compounds. J Nat Prod 2009; 72(6):1220-30.
  17. Depypere HT, Comhaire FH. Herbal preparations for the menopause: beyond isoflavones and black cohosh. Maturitas 2014; 77(2):191-4.
  18. Hosseini SE. Effect of aalcoholic extract of hop flowers on serum level pituitary-thyroid hormones in adult male rats. J Birjand Univ Med Sci 2015; 21(4):425-31.
  19. Lethaby A, Marjoribanks J, Kronenberg F, Roberts H, Eden J, Brown J. Phytoestrogens for menopausal vasomotor symptoms. Cochrane Database Syst Rev 2013; 12:CD001395.
  20. Heyerick A, Vervarcke S, Depypere H, Bracke M, De Keukeleire D. A first prospective, randomized, double-blind, placebo-controlled study on the use of a standardized hop extract to alleviate menopausal discomforts. Maturitas 2006; 54(2):164-75.
  21. Rosic S, Kendic S, Rosic M. Phytoestrogens impact on menopausal symptomatology. Mater Sociomed 2013; 25(2):98-100.
  22. Mohammad-Alizadeh-Charandabi S, Mirghafourvand M, Aghamiri V, Nazemiyeh H, Soltanpoor S. Efficacy of hop (Humuluslupulus L.) on early menopausal symptoms in perimenopausal women: a randomized double blind placebo-controlled trial. Sci J Kurdistan Univ Med Sci 2014; 19(3):12-22.
  23. Gopalakrishnan S, Ganeshkumar P. Systematic reviews and meta-analysis: understanding the best evidence in primary healthcare. J Family Med Prim Care 2013; 2(1):9-14.
  24. Abdi F, Kazemi F, Ramezani Tehrani F, Roozbeh N. Protocol for systematic review and meta-analysis: hop (Humulus lupulus L.) for menopausal vasomotor symptoms. BMJ Open 2016; 6(4):e010734.
  25. Higgins JP, Altman DG, Gøtzsche PC, Jüni P, Moher D, Oxman AD, et al. The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials. BMJ 2011; 343:d5928.
  26. Mirghafourvand M, Mohammad-Alizadeh-Charandabi S, Aghamiri V, Nazemiyeh H, Soltanpoor S. The effect of Hop (Humulus lupulus L.) in treating early menopausal symptoms in post-menopausal women: a randomized clinical-controlled trial. Razi J Med Sci 2015; 22(131):14-24.
  27. Erkkola R, Vervarcke S, Vansteelandt S, Rompotti P, De Keukeleire D, Heyerick A. A randomized, double-blind, placebo-controlled, cross-over pilot study on the use of a standardized hop extract to alleviate menopausal discomforts. Phytomedicine 2010; 17(6):389-96.
  28. Aghamiri V, Mirghafourvand M, Mohammad-Alizadeh-Charandabi S, Nazemiyeh H. The effect of Hop (Humulus lupulus L.) on early menopausal symptoms and hot flashes: a randomized placebo-controlled trial. Complement Ther Clin Pract 2016; 23:130-5.
  29. Lagari VS, Levis S. Phytoestrogens for menopausal bone loss and climacteric symptoms. J Steroid Biochem Mol Biol 2014; 139:294-301.
  30. Abdi F, Mobedi H, Roozbeh N. Hops for menopausal vasomotor symptoms: mechanisms of action. J Menopausal Med 2016; 22(2):62-4.
  31. Zanoli P, Zavatti M. Pharmacognostic and pharmacological profile of Humulus lupulus L. J Ethnopharmacol 2008; 116(3):383-96.
  32. Kuhrts E. Hops extraction methods and mixtures. Virginia, US: United States Patent and Trademark Office; 2008.
  33. Bowe J, Li XF, Kinsey-Jones J, Heyerick A, Brain S, Milligan S, et al. The hop phytoestrogen, 8-prenylnaringenin, reverses the ovariectomy-induced rise in skin temperature in an animal model of menopausal hot flushes. J Endocrinol 2006; 191(2):399-405.
  34. Morali G, Polatti F, Metelitsa EN, Mascarucci P, Magnani P, Marrè GB. Open, non-controlled clinical studies to assess the efficacy and safety of a medical device in form of gel topically and intravaginally used in postmenopausal women with genital atrophy. Arzneimittelforschung 2006; 56(3):230-8.
مجله زنان، مامایی و نازایی ایران
دوره 19، شماره 26
هفته دوم مهر ماه 1395
مهر 1395
صفحه 9-17

فایل ها

هم رسانی

ارجاع به این مقاله

آمار