تأثیر مصرف الکل بر سلامت باروری و چرخه قاعدگی در دختران نوجوان: یک مطالعه مرور نظام‌مند

نوع مقاله : مروری

نویسندگان

1 دانشجوی دکتری سلامت باروری، کمیته تحقیقات دانشجویی، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران. گروه مامایی، واحد ارومیه، دانشگاه آزاد اسلامی، ارومیه، ایران.

2 استادیار گروه بهداشت عمومی، دانشکده علوم پزشکی خوی، خوی، ایران.

3 استاد گروه مامایی و بهداشت باروری، مرکز تحقیقات مامایی و بهداشت باروری، دانشکدۀ پرستاری و مامایی، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران.

4 دانشجوی دکتری سلامت باروری، کمیته تحقیقات دانشجویی، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران.

10.22038/ijogi.2025.91188.6552

چکیده

مقدمه: با توجه به شیوع روزافزون مصرف الکل در نوجوانان، بررسی تأثیرات آن بر سلامت باروری اهمیت زیادی دارد. این مطالعه با هدف مرور نظام‌مند شواهد موجود درباره ارتباط مصرف الکل و پیامدهای مرتبط با چرخه قاعدگی و باروری در نوجوانان دختر انجام شد.
روش‌کار: در این مطالعه مرور نظام‌مند که با هدف بررسی تأثیر مصرف الکل بر باروری و چرخه قاعدگی در نوجوانان دختر انجام شد، جستجو در پایگاه‌های اطلاعاتی PubMed، Scopus، Web of Science، Embase،Cochran library، Google Scholar، SID و Magiran برای مطالعات مشاهده‌ای منتشر شده از ۲۰۱۰ تا ژانویه ۲۰۲۵ انجام گرفت. فرآیند غربالگری، استخراج داده‌ها و ارزیابی کیفیت به‌صورت مستقل توسط دو پژوهشگر انجام گرفت. از میان 911 مقاله شناسایی‌ شده، 6 مطالعه مطالعه واجد شرایط برای تحلیل نهایی انتخاب شدند. تجزیه و تحلیل داده‌ها به‌صورت کیفی و با رویکرد مرور جامع انجام شد.
یافته ­ها: در مجموع 6 مطالعه واجد شرایط وارد مرور نهایی شدند. یافته‌های مرور حاضر نشان داد که مصرف الکل در میان دختران نوجوان با مجموعه‌ای از مشکلات قاعدگی و پیامدهای باروری مرتبط است. مصرف الکل به‌عنوان یک رفتار پرخطر، اغلب همراه با سایر عادات ناسالم مانند سیگار و بی‌تحرکی بروز کرده و با افزایش بروز بی‌نظمی‌های قاعدگی، سندرم پیش‌قاعدگی، دیسمنوره و حتی باروری زودرس یا ناخواسته همراه بود.
نتیجه­ گیری: این مرور نظام‌مند نشان داد که مصرف الکل می‌تواند یکی از عوامل مؤثر و مداخله‌گر در سلامت باروری و چرخه قاعدگی دختران نوجوان باشد. یافته‌ها ضرورت توجه به مصرف الکل در برنامه‌های آموزش سلامت باروری، طراحی مداخلات چندسطحی پیشگیرانه و اجرای پژوهش‌های طولی با ابزارهای استاندارد برای بررسی روابط علّی را برجسته می‌سازد.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

The Effect of Alcohol Consumption on Reproductive Health and Menstrual Cycle in Adolescent Girls: A Systematic Review

نویسندگان [English]

  • Fatemeh Sara Aparnak 1
  • Morad Ali Zareipour 2
  • Hedyeh Riazi 3
  • Shiva Shams Danesh 4
  • Masoumeh Simbar 3
1 Ph.D. Candidate of Reproductive Health, Student Research Committee, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Department of Midwifery, Urmia Branch, Islamic Azad University, Urmia, Iran.
2 Assistant Professor, Department of Public Health, Khoy University of Medical Sciences, Khoy, Iran.
3 Professor, Department of Midwifery and Reproductive Health, Midwifery and Reproductive Health Research Center, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
4 Ph.D. Candidate of Reproductive Health, Student Research Committee, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
چکیده [English]

Introduction: Given the increasing prevalence of alcohol consumption in adolescence, examining its impact on reproductive health is of great importance. This study was conducted with aim to systematically review the available evidence on the association between alcohol consumption and outcomes related to menstrual cycle and fertility among adolescent girls.
Methods: In this study systematic review which was conducted with aim to investigate the impact of alcohol consumption on fertility and the menstrual cycle in adolescent girls, search was conducted in the databases of PubMed, Scopus, Web of Science, Embase, the Cochrane Library, Google Scholar, SID, and Magiran for observational studies published from 2010 through January 2025. The screening process, data extraction, and quality assessment were performed independently by two researchers. Out of 911 initially identified records, 6 studies met the eligibility criteria and were selected for the final analysis. Data analysis was performed qualitatively using a narrative synthesis approach.
Results: A total of 6 studies which met the inclusion criteria included in the final review. Findings revealed that alcohol consumption among adolescent girls is associated with a range of menstrual problems and reproductive outcomes. Alcohol use, as a high-risk behavior, often co-occurs with other unhealthy habits such as smoking and physical inactivity, and is linked to increased menstrual irregularities, premenstrual syndrome (PMS), dysmenorrhea, and even early or unintended pregnancy.
Conclusion: This systematic review showed that alcohol consumption can be an influential factor affecting reproductive health and menstrual cycle regulation in adolescent girls. The findings highlight the need to address alcohol use in reproductive health education programs, designing multi-level preventive interventions, and conducting longitudinal studies using standardized measures to clarify causal relationships.

کلیدواژه‌ها [English]

  • Alcohol Consumption
  • Adolescent Girl
  • Menstrual Cycle
  • Reproductive Health
  • Systematic Review

مراجع

  1. World Health Organization. Alcohol, e-cigarettes, cannabis: Concerning trends in adolescent substance use, shows new WHO Europe report; 2024.
  2. T. England is worst in world for under-age drinking [Internet]. London: The Times; 2024 Apr 25 2025 Aug 16 [Available from: https://www.thetimes.co.uk/article/england-worst-world-under-age-drinking-wxhjprsmb.
  3. Kelly Y, Goisis A, Sacker A, Cable N, Watt RG, Britton A. What influences 11-year-olds to drink? Findings from the Millennium Cohort Study. BMC public health 2016; 16(1):169.
  4. Podolskyi VV, Podolskyi VV, Rybinskyі YM. Вплив алкоголю на рівні статевих гормонів жінок фертильного віку з хронічними запальними захворюваннями, спричиненими інфекціями, що передаються статевим шляхом. Reproductive Endocrinology 2025; 31(76):51-6.
  5. Schliep KC, Zarek SM, Schisterman EF, Wactawski-Wende J, Trevisan M, Sjaarda LA, et al. Alcohol intake, reproductive hormones, and menstrual cycle function: a prospective cohort study. The American Journal of Clinical Nutrition 2015; 102(4):933-42.
  6. Vore AS, Doremus-Fitzwater T, Gano A, Deak T. Adolescent ethanol exposure leads to stimulus-specific changes in cytokine reactivity and hypothalamic-pituitary-adrenal axis sensitivity in adulthood. Frontiers in behavioral neuroscience 2017; 11:78.
  7. Briegal E, Biggane AM, Obasi AI. Adolescent alcohol consumption: protocol for a scoping review of screening and assessment tools used in Africa. Systematic Reviews 2021; 10(1):100.
  8. Chauhan S, Kumar P, Patel R, Srivastava S, Simon DJ, Muhammad T. Association of lifestyle factors with menstrual problems and its treatment-seeking behavior among adolescent girls. Clinical Epidemiology and Global Health 2021; 12:100905.
  9. Rylewicz K, Drejza MA, Łopiński G, Majcherek E, Barwińska J, Mizgier M, et al. Correlates of Premenstrual Syndrome in Polish Adolescents—Results from POLKA 18 Youth-Led Cross-Sectional Study. Journal of Clinical Medicine 2024; 13(23):7342.
  10. Ryskeldiyeva K, Moldaliyev I, Tuktibaeva S, Nurkhassimova R, Kurbaniyazova S, Kushkarova A, et al. Knowledge, attitude and practice of adolescent girls towards reproductive health: a cross-sectional study in Turkistan region, Kazakhstan. Future Science OA 2023; 9(3):FSO840.
  11. Jiang Z, He R, Wu H, Yu J, Zhu K, Luo Q, et al. The causal association between smoking initiation, alcohol and coffee consumption, and women’s reproductive health: a two-sample Mendelian randomization analysis. Frontiers in Genetics 2023; 14:1098616.
  12. Al Rashid K, Taylor A, Lumsden MA, Goulding N, Lawlor DA, Nelson SM. Association of the functional ovarian reserve with serum metabolomic profiling by nuclear magnetic resonance spectroscopy: a cross-sectional study of~ 400 women. BMC medicine 2020; 18(1):247.
  13. Stroup DF, Berlin JA, Morton SC, Olkin I, Williamson GD, Rennie D, et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting. Jama 2000; 283(15):2008-12.
  14. Morgan RL, Whaley P, Thayer KA, Schünemann HJ. Identifying the PECO: a framework for formulating good questions to explore the association of environmental and other exposures with health outcomes. Environment international 2018; 121:1027-31.
  15. Almeida GM, Oliveira KH, Monteiro JS, Medeiros MA, Recine EG. Educational training of nutritionists in Public Health Nutrition: A systematic review. Revista de Nutrição 2018; 31(1):97-117.
  16. De Sanctis V, Bernasconi S, Bianchin L, Bona G, Bozzola M, Buzi F, et al. Onset of menstrual cycle and menses features among secondary school girls in Italy: A questionnaire study on 3,783 students. Indian journal of endocrinology and metabolism 2014; 18(Suppl 1):S84-92.
  17. Halkjelsvik T, Skirbekk VF. Concurrent decline in teenage fertility rate and binge drinking? An observational study across 45 nations. Drug and Alcohol Review 2024; 43(6):1451-60.
  18. Al-Husban N, Odeh O, Dabit T, Masadeh A. The influence of lifestyle variables on primary dysmenorrhea: a cross-sectional study. International journal of women's health 2022: 545-53.
  19. de Angelis C, Nardone A, Garifalos F, Pivonello C, Sansone A, Conforti A, et al. Smoke, alcohol and drug addiction and female fertility. Reproductive biology and endocrinology 2020; 18(1):21.
  20. Rachdaoui N, Sarkar DK. Pathophysiology of the effects of alcohol abuse on the endocrine system. Alcohol research: current reviews 2017; 38(2):255.
  21. Finn DA. The endocrine system and alcohol drinking in females. Alcohol research: current reviews 2020; 40(2):02.
  22. Liu Y, Zuo H, Wang Y, Tian L, Xu X, Xiong J, et al. Ethanol promotes apoptosis in rat ovarian granulosa cells via the Bcl-2 family dependent intrinsic apoptotic pathway. Cellular and molecular biology 2018; 64(1):118-25.
  23. Verhoef M, van den Eijnden RJ, Koning IM, Vollebergh WA. Age at menarche and adolescent alcohol use. Journal of youth and adolescence 2014; 43(8):1333-45.
  24. Sharma R, Biedenharn KR, Fedor JM, Agarwal A. Lifestyle factors and reproductive health: taking control of your fertility. Reproductive biology and endocrinology 2013; 11(1):66.
  25. Onieva-Zafra MD, Fernández-Martínez E, Abreu-Sánchez A, Iglesias-López MT, García-Padilla FM, Pedregal-González M, et al. Relationship between diet, menstrual pain and other menstrual characteristics among Spanish students. Nutrients 2020; 12(6):1759.
  26. Franco-Antonio C, Santano-Mogena E, Cordovilla-Guardia S. Dysmenorrhea, premenstrual syndrome, and lifestyle habits in young university students in Spain: A cross-sectional study. Journal of Nursing Research 2025; 33(1):e374.
  27. Drejza M, Rylewicz K, Majcherek E, Barwińska J, Łopiński G, Mizgier M, et al. Dysmenorrhea in polish adolescent girls: impact on physical, mental, and social well-being—results from POLKA 18 study. Journal of Clinical Medicine 2024; 13(20):6286.
  28. Hoffmann S, Gerhardt S, Mühle C, Reinhard I, Reichert D, Bach P, et al. Associations of menstrual cycle and progesterone-to-estradiol ratio with alcohol consumption in alcohol use disorder: a sex-separated multicenter longitudinal study. American Journal of Psychiatry 2024; 181(5):445-56.
  29. Carroll HA, Lustyk MK, Larimer ME. The relationship between alcohol consumption and menstrual cycle: a review of the literature. Archives of women's mental health 2015; 18(6):773-81.
مجله زنان، مامایی و نازایی ایران
دوره 28، شماره 9
آذر 1404
صفحه 73-86

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