بررسی ارتباط پلی‌مورفیسم ژن (rs5219) KCNJ11 با استعداد ابتلاء به دیابت بارداری: یک مرور متاآنالیز

نوع مقاله : مروری

نویسندگان

1 کارشناس ارشد فیزیولوژی پزشکی، کمیته تحقیقات دانشجویی، دانشکده پزشکی، دانشگاه علوم پزشکی جندی شاپور اهواز، اهواز، ایران.

2 دکتری تخصصی فیزیولوژی پزشکی، مرکز تحقیقات گیاهان دارویی، دانشکده داروسازی، دانشگاه علوم پزشکی جندی شاپور اهواز، اهواز، ایران.

3 دکتری تخصصی فیزیولوژی پزشکی، مرکز تحقیقات فیزیولوژی خلیج فارس، پژوهشکده علوم پایه پزشکی، دانشگاه علوم پزشکی جندی شاپور اهواز، اهواز، ایران.

4 دکتری تخصصی اپیدمیولوژی، گروه پزشکی اجتماعی، دانشکده پزشکی، دانشگاه علوم پزشکی جندی شاپور اهواز، اهواز، ایران.

5 کارشناس ارشد ژنتیک، گروه زیست‌شناسی، دانشکده علوم، دانشگاه شهید چمران، اهواز، ایران.

6 دکتری تخصصی ژنتیک مولکولی، گروه زیست‌شناسی، دانشکده علوم، دانشگاه شهید چمران، اهواز، ایران.

7 کارشناس ارشد ژنتیک پزشکی، گروه‌ ژنتیک‌ پزشکی، دانشکده پزشکی، دانشگاه جندی‌شاپور اهواز، اهواز، ایران.

8 کارشناس ارشد هماتولوژی، کمیته تحقیقات دانشجویی، دانشکده پیراپزشکی، دانشگاه علوم پزشکی جندی شاپور، اهواز، ایران.

چکیده

مقدمه: تغییر در فعالیت ژن کانال پتاسیم یک‌سو کننده‌ داخلی زیرخانواده J عضو 11 KCNJ11 به‌دلیل وجود برخی از پلی‌مورفیسم‌‌های این ژن، اثرات گسترد‌ه‌ای بر روی فرآیندهای متابولیک افراد مبتلا به دیابت بارداری (GDM) دارد. مطالعه مرور سیستماتیک و متاآنالیز حاضر با هدف ارزیابی دقیق‌تر ارتباط بین پلی‌مورفیسم (rs5219)KCNJ11 و GDM انجام شد.
روش‌کار: در این بررسی سیستماتیک و متاآنالیز، جستجوی ادبیات برای شناسایی مقالات مرتبط در پایگاه‌های الکترونیکی مانند PubMed، Web of Science، Scopus، Cochrane، EMBASE و برخی پایگاه‌های فارسی زبان انجام شد. از نسبت شانس OR و فاصله اطمینان 95% برای ارزیابی ارتباط بین پلی‌مورفیسم‌های (rs5219)KCNJ11 و استعداد ابتلاء به GDM در چهار مدل ژنتیکی استفاده شد.
یافته ­ها: در مجموع تعداد 5578 شرکت‌کننده از 6 مقاله وارد متاآنالیز شدند. ارتباط معنی‌داری بین پلی‌مورفیسم ژن (rs5219)KCNJ11 و GDM در جمعیت مورد مطالعه از طریق مدل ژنتیک جمعی (049/0=p؛ 30/1-00/1: CI 95%؛ 14/1=OR) و مدل ژنتیکی مغلوب (033/0=p؛ 98/0-75/0: CI 95%؛ 86/0=OR) شناسایی شد. در مقابل، هیچ ارتباط معنی‌داری بین پلی‌مورفیسم ژن (rs5219)KCNJ11 و GDM بر اساس مدل ژنتیکی آللی (136/0=p؛ 69/1-93/0: CI 95%؛ 25/1=OR) و مدل ژنتیکی غالب (157/0=p؛ 41/1-94/0: CI 95%؛ 15/1=OR) وجود نداشت.
نتیجه ­گیری: پلی‌مورفیسم ژن KCNJ11 با استعداد ابتلاء به GDM در زنان مرتبط است. با این‌حال، مطالعات بیشتری بر اساس نژادهای مختلف برای تأیید نتایج مطالعه حاضر مورد نیاز است. 

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

Association of KCNJ11 (rs5219) gene polymorphism with susceptibility to gestational diabetes mellitus: a review and meta-analysis

نویسندگان [English]

  • Seyed Sobhan Bahreiny 1
  • Akram Ahangarpour 2
  • Khojasteh Hoseinynejad 3
  • Saeid Bitaraf 4
  • Mohammad Reza Dabbagh 5
  • Mohadeseh Aghli Moghadam 6
  • Amir Hossein Mahdizade 7
  • Mojtaba Aghaei 8
1 M.Sc. in Medical physiology, Student Research Committee, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
2 Ph.D. in Medical physiology, Medicinal Plants Research Center, School of Pharmacology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
3 Ph.D. in Medical physiology, Persian Gulf Physiology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
4 PhD in Epidemiology, Department of Community Medicine, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
5 M.Sc. in Genetics, Department of Biology, School of Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
6 Ph.D. in Molecular Genetics, Department of Biology, School of Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
7 M.Sc. in Medical Genetics, Department of Medical Genetics, Faculty of Medicine, Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran.
8 M.Sc. in Hematology, Student Research Committee, Faculty of paramedicine, Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran.
چکیده [English]

Introduction: Changes in the activity of the gene encoding internal rectifier potassium inwardly rectifying channel, subfamily J, member 11 (KCNJ11), due to some polymorphisms of this gene have far-reaching effects on the metabolic processes of people with gestational diabetes mellitus (GDM). This systematic review and meta-analysis were conducted with aim to further evaluate the association between the KCNJ11 (rs5219) polymorphism and GDM. 
Methods: In this systematic review and meta-analysis, a literature search was performed to identify the relevant articles in electronic databases such as PubMed, Web of Science, Scopus, Cochrane, EMBASE, and some Persian-language databases. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to evaluate the association between KCNJ11 (rs5219) polymorphisms and susceptibility to GDM in four genetic models.
Results: A total of 5578 participants from six articles were included in the meta-analysis. A significant relationship was identified between the KCNJ11 (rs5219) gene polymorphism and GDM in the study population through an additive genetic model (OR = 1.14; 95%CI: 1.00–1.30; P = 0.049) and a recessive genetic model (OR = 0.86; 95% CI: 0.75–0.98; P = 0.033). On the contrary, there was no significant association between the KCNJ11 (rs5219) gene polymorphism and GDM in an allelic genetic model (OR = 1.25; 95%CI: 0.93–1.69; P = 0.136) and the dominant genetic model (OR = 1.15; 95% CI: 0.94–1.41; P = 0.157).
Conclusion: The KCNJ11 gene polymorphism (rs5219) is associated with susceptibility to GDM in women. However, more studies on different ethnicities are required to confirm our results.

کلیدواژه‌ها [English]

  • Gestational diabetes mellitus
  • KCNJ11
  • Meta-analysis
  • Polymorphism KCNJ11 (rs5219)

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مجله زنان، مامایی و نازایی ایران
دوره 27، شماره 1
فروردین 1403
صفحه 63-79

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