ویروس پاپیلومای انسانی و بارداری: یک مطالعه مروری نقلی

نوع مقاله : مروری

نویسندگان

1 کارشناس ارشد بیوشیمی بالینی، مرکز تحقیقات عفونت‌های منتقله از خون، سازمان جهاد دانشگاهی خراسان رضوی، مشهد، ایران.

2 استاد گروه انگل‌شناسی و قارچ‌شناسی، دانشکده پزشکی، دانشگاه علوم پزشکی مشهد، مشهد، ایران. سازمان جهاد دانشگاهی خراسان رضوی، مشهد، ایران.

3 استاد گروه زنان و مامایی، هسته تحقیقاتی حمایت از خانواده و جوانی جمعیت، دانشکده پزشکی، دانشگاه علوم پزشکی مشهد، مشهد، ایران.

4 دکترای تخصصی پزشکی مولکولی، مرکز تحقیقات عفونت‌های منتقله از خون، جهاد دانشگاهی خراسان رضوی، مشهد، ایران.

چکیده

مقدمه: ویروس پاپیلومای انسانی (HPV) شایع‌ترین عفونت منتقله از راه جنسی است. ویروس HPV در صورت پایداری در بدن، عامل ایجاد چندین سرطان در ناحیه آنوژنیتال و اوروفارنکس است. ابتلاء به ویروس HPV در دوران بارداری ممکن است با پیامدهای نامطلوبی همچون زایمان زودرس و سقط جنین همراه باشد؛ مطالعه حاضر با هدف بررسی ارتباط عفونت HPV با پیامدهای نامطلوب بارداری در مطالعات مختلف انجام شد.
روش‌کار: در این مطالعه مروری نقلی، برای یافتن مقالات مرتبط، پایگاه‌های PubMed و Google Scholar با استفاده از کلمات کلیدی HPV، Papillomavirus، HPV in Pregnancy، HPV Transmission و Adverse outcomes از سال 2000 تا 2022 جستجو شدند. بدین‌منظور مقالات پژوهشی اصیل، کارآزمایی بالینی، مروری و گزارش موردی مرتبط با موضوع مورد بررسی وارد مطالعه شده و مطالعات غیرمرتبط حذف شدند. فرآیند گزینش مقالات به‌ترتیب با مطالعه عنوان، چکیده و محتوا انجام شد. زبان پذیرش مقالات انگلیسی بود.
یافته ­ها: نتایج مطالعات نشان داده‌اند که خطر ابتلاء به عفونت HPV در زنان باردار نسبت به زنان غیرباردار بالاتر است. همچنین خطر زایمان زودرس و پارگی زودرس کیسه آب در زنان باردار HPV مثبت بیشتر از زنان HPV منفی گزارش شده ­است. برخی مطالعات به ارتباط HPV و مرگ خودبه‌خودی جنین نیز اشاره نموده‌اند.
نتیجه ­گیری: با توجه به عوارض متعدد ابتلاء به عفونت HPV در زنان باردار، بهتر است قبل از بارداری از عدم ابتلاء به این ویروس، اطمینان حاصل شود.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

Human papillomavirus and pregnancy: A narrative review study

نویسندگان [English]

  • Azam Shafaei 1
  • Seyyed Ali Akbar Shamsian 2
  • Fatemeh Tara 3
  • Maryam Shahi 4
1 M.Sc. of Clinical Biochemistry, Blood Borne Infections Research Center, Academic Center for Education, Culture and Research (ACECR), Razavi Khorasan Branch, Mashhad, Iran.
2 Professor, Department of Parasitology and Mycology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Iranian Academic Center for Education, Culture and Research (ACECR), Mashhad Branch, Iran.
3 Professor, Department of Obstetrics and Gynecology, Supporting the Family and the Youth of Population Research Core, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
4 PhD of Molecular Medicine, Blood Borne Infections Research Center, Academic Center for Education, Culture and Research (ACECR), Razavi Khorasan Branch, Mashhad, Iran.
چکیده [English]

Introduction: Human papillomavirus (HPV) is the most common sexual transmitted infection. The persistence of HPV infection causes different types of anogenital and oropharyngeal cancer. HPV infection during pregnancy may be associated with several adverse consequences, such as preterm birth and miscarriage. The present study was performed with aim to investigate the relationship between HPV infection and adverse pregnancy outcomes in different studies.
Methods: In this narrative review, to find relevant articles, PubMed and Google Scholar databases were searched using the keywords HPV, Papillomavirus, HPV in Pregnancy, HPV Transmission and Adverse outcomes from 2000 to 2022. For this purpose, original research articles, clinical trials, reviews and case reports related to the subject of this review were included in the study and unrelated studies were excluded. The review of the articles was done by reading the title, abstract and content, respectively. The language on the admission papers was English.
Results: The results of the different studies have shown that the risk of HPV infection in pregnant women is higher than in non-pregnant women. Also, the risk of preterm birth and preterm premature rupture of the membranes is reported to be higher in HPV positive pregnant women in comparison with HPV negative women. Some studies have also pointed to the relationship between HPV infection and spontaneous fetal death.
Conclusion: Considering many complications of HPV infection in pregnant women, it is better to ensure about non-infection with this virus before pregnancy.

کلیدواژه‌ها [English]

  • Cancer
  • Human papillomavirus
  • Pregnancy
  • Vaccination

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مجله زنان، مامایی و نازایی ایران
دوره 27، شماره 2
اردیبهشت 1403
صفحه 60-70

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