بررسی نقش ریزمغذی‌ها بر فاکتورهای مؤثر در باروری زنان مبتلا به سندرم تخمدان پلی‌کیستیک: یک مطالعه مرور نظام‌مند

نوع مقاله : مروری

نویسندگان

1 دانشجوی دکتری بهداشت باروری، مرکز تحقیقات مامایی و بهداشت باروری، کمیته تحقیقات دانشجویان، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران.

2 استادیار، مرکز تحقیقات مامایی و بهداشت باروری، گروه مامایی و بهداشت باروری، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران.

چکیده

مقدمه: سندرم تخمدان پلی­ کیستیک (PCOS)، شایع‌ترین اختلال غدد درون‌ریز می ­باشد و رژیم غذایی می­تواند بر روی آن تأثیرگذار باشد. با توجه به شیوع بالای سندرم تخمدان پلی ­کیستیک در زنان و تبعات منفی باروری که برجای می­ گذارد، مطالعه مروری حاضر با هدف بررسی نقش ریزمغذی­ ها بر باروری زنان مبتلا به سندرم تخمدان پلی­ کیستیک انجام شد.
روش‌کار: در این مطالعه مرور سیتماتیک جهت یافتن مقالات مرتبط، پایگاه­ های اطلاعاتی بین‌المللی (Science Direct، Embase، Scopus، PubMed) و پایگاه­ های فارسی زبان (Magiran، SID و Iran Medex) با ترکیب مختلف کلمات کلیدی مرتبط با "سندرم تخمدان پلی‌کیستیک"، "ریزمغذی‌ها" و "باروری" بدون محدویت زمانی تا فوریه سال 2023 با استفاده از مقیاس ورهاگن مورد بررسی قرار گرفتند.
یافته­ ها: از 1080 مقاله بررسی شده، در نهایت 13 مقاله وارد مطالعه شدند. 5 مطالعه به مکانسیم­ های غیرمستقیم تأثیرگذار ریزمغذی­ها بر فاکتورهای مؤثر بر باروری پرداخته بودند که در 2 مطالعه، تفاوت آماری معنی‌داری مشاهده نشد و در 3 مطالعه اثرات مفید بر متابولیسم انسولین و پارامترهای لیپیدی، تنظیم قاعدگی، تنظیم نسبت LH/FSH گزارش شد. از 8 مطالعه‌ای که به عملکرد تخمدان پرداختند، 7 مطالعه به بهبود عملکرد تخمدان دست یافته بودند. اکثر مطالعات بیانگر اثرات مثبت ریزمغذی­ ها بر باروری زنان مبتلا به سندرم تخمدان پلی­ کیستیک بودند.
نتیجه ­گیری: به‌نظر می‌رسد ریزمغذی‌ها با بهبود باروری زنان مبتلا به سندرم تخمدان پلی‌کیستیک مرتبط می‌باشند.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

The Role of Micronutrients on Fertility of Women with Polycystic Ovary Syndrome: A Systematic Review

نویسندگان [English]

  • Seyedeh Maryam Khalili 1
  • Marjan Havaei 1
  • Elnaz Haji Rafiei 1
  • Leila Alizadeh 1
  • Fereshte Ghahremani 1
  • Seideh Hanieh Alamolhoda 2
1 PhD Student of Reproductive Health, Midwifery and Reproductive Health Research Center, Students Research Committee, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2 Assistant Professor, Midwifery and Reproductive Health Research Center, Department of Midwifery and Reproductive Health, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
چکیده [English]

Introduction: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder and diet can affect it. Considering the high prevalence of polycystic ovary syndrome in women and its negative consequences on fertility, this review study was conducted with aim to investigate the role of micronutrients on the fertility of women with polycystic ovary syndrome.
Methods: In this systematic review study, to find the related articles, international databases (ScienceDirect, Embase, Scopus, PubMed) and Persian language databases (Magiran, SID and IranMedex) were searched with different combinations of keywords related to "polycystic ovary syndrome" and " "micronutrients" and "fertility" without time limit until February 2023 using the Verhagen scale.
Results: Out of 1080 reviewed articles, finally 13 articles were included in the study. Five studies investigated the indirect mechanisms of micronutrients on factors affecting fertility; in two studies, no statistically significant difference was observed, and in three studies, beneficial effects on insulin metabolism and lipid parameters, regulation of menstruation, regulation of LH/FSH ratio were reported. Of the eight studies that investigated ovarian function, seven studies found improved ovarian function. Most of the studies showed the positive effects of micronutrients on the fertility of women with polycystic ovary syndrome.
Conclusion: Micronutrients seem to be associated with improved fertility in women with polycystic ovary syndrome.

کلیدواژه‌ها [English]

  • Polycystic ovary syndrome
  • Micronutrients
  • Fertility
  • Systematic review

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مجله زنان، مامایی و نازایی ایران
دوره 26، شماره 11
بهمن 1402
صفحه 57-70

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