تأثیر قرص ویتامین B6 بر درد پستان سه ماهه اول بارداری در زنان باردار مراجعه کننده به مراکز جامع سلامت شهر گناباد سال 99-1398

نوع مقاله : اصیل پژوهشی

نویسندگان

1 دانشجوی کارشناسی ارشد مامایی، کارگروه دانشجویی مرکز تحقیقات سلامت باروری و جمعیت، دانشکده پزشکی، دانشگاه علوم پزشکی گناباد، گناباد، ایران.

2 دانشیار گروه مامایی، مرکز تحقیقات سلامت باروری و جمعیت، دانشکده پزشکی، دانشگاه علوم پزشکی گناباد، گناباد، ایران.

3 دانشیار گروه مامایی، مرکز تحقیقات مراقبت‌های پرستاری و مامایی، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی مشهد، مشهد، ایران.

4 دانشیار گروه علوم تغذیه و بیوشیمی، مرکز تحقیقات سلامت باروری و جمعیت، دانشکده پزشکی، دانشگاه علوم پزشکی گناباد، گناباد، ایران.

چکیده

مقدمه: سه ماهه‌ اول بارداری برای مادران باردار با تجارب ناخوشایندی همراه است. یکی از این تجارب ناخوشایند، درد پستان است که منجر به کیفیت زندگی پایین در زنان باردار می‌گردد، لذا مطالعه حاضر با هدف بررسی اثر ویتامین B6 به‌عنوان یک مکمل ایمن و دردسترس بر درد پستان سه‌ماهه اول بارداری انجام شد.
روش‌کار: این مطالعه کارآزمایی بالینی شاهددار تصادفی شده در سال 99-1398 بر روی زنان با سن بارداری 10-6 هفته و داشتن درد پستان با شروع بارداری به‌مدت 5 روز یا بیشتر در شهر گناباد انجام شد. افراد در دو گروه  42 نفره کنترل و مداخله قرار گرفتند. به گروه کنترل روزانه یک عدد دارونما و به گروه مداخله یک عدد قرص 40 میلی‌گرمی ویتامین B6 به‌مدت 1 ماه داده شد. پرسشنامه مقیاس دیداری درد قبل و یک ماه بعد از مداخله به واحدهای پژوهش داده شد. مقادیر ویتامین B6 دریافتی از رژیم غذایی گروه‌ها از طریق پرسشنامه یادآور 24 ساعته غذا و نرم‌افزار N4  به‌دست آمد. تجزیه و تحلیل داده‌ها با استفاده از نرم‌افزار SPSS  (نسخه 20) و آزمون­های تی­مستقل، من­ویتنی، کای­دو، فیشر، ویلکاکسون و رگرسیون انجام شد. میزان p کمتر از 05/0 معنادار در نظر گرفته شد.
یافته ­ها: بین سن بارداری در دو گروه تفاوت آماری معناداری وجود داشت (04/0=p)، ولی سایر متغیرهای بارداری دو گروه همگن بودند (05/0<p). بر اساس نتایج آزمون من­ویتنی، بین میانگین نمره درد پستان بعد از مداخله در دو گروه تفاوت معناداری وجود نداشت (2/0=p).
نتیجه­ گیری: اثر مصرف خوراکی ویتامین B6 نسبت به پلاسبو بر روی کاهش نمره درد پستان سه‌ماهه اول بارداری تأثیرگذار نیست. مطالعات بیشتر با حجم نمونه بزرگ‌تر، دوزهای مختلف ویتامین B6 و همراه با سنجش سطح سرمی ویتامین B6 پیشنهاد می ­گردد.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

The effect of vitamin B6 on the breast pain in first trimester of pregnancy in pregnant women referring to the comprehensive health centers in Gonabad, 2019-2020

نویسندگان [English]

  • Asma Salar 1
  • Roqhaieh Rahmani Bilandi 2
  • Fatemeh Hadizadeh Talasaz 3
  • Elyas Nattagh Eshtivani 4
1 M.Sc. student of Midwifery, Student Working Group of Reproductive Health and Population Research Center, Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran.
2 Associate professor, Department of Midwifery, Reproductive Health and Population Research Center, Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran.
3 Associate professor, Department of Midwifery, Nursing and Midwifery Care Research Center, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran.
4 Associate Professor, Department of Nutrition Sciences and Biochemistry, Reproductive Health and Population Research Center, Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran.
چکیده [English]

Introduction: The first trimester of pregnancy is associated with unpleasant experiences for mothers. One of these unpleasant experiences is breast pain, which leads to a low quality of life in pregnant women, so the present study was conducted with aim to investigate the effect of vitamin B6 as a safe and available supplement on breast pain in the first trimester of pregnancy.
Methods: This randomized controlled clinical trial study was conducted in 2019-2020 on women with a gestational age of 6-10 weeks who had breast pain with start of pregnancy for 5 days or more in Gonabad city. Pregnant women were divided into two groups of 42 people, control and intervention. The control group was given a placebo daily and the intervention group was given a 40 mg vitamin B6 pill for 1 month. The visual pain scale questionnaire was given to the research units before and one month after the intervention. The amounts of vitamin B6 received from the diet of the groups were obtained through a 24-hour food reminder questionnaire and N4 software. Data analysis was done using SPSS software (version 20) and independent t-tests, Mann-Whitney, Chi-square, Fisher, Wilcoxon and regression. P<0.05 was considered significant.
Results: There was a statistically significant difference between the two groups regarding the gestational age (p=0.04), but other pregnancy variables were homogeneous in the two groups (p>0.05). According to Mann-Whitney test results, there was no significant difference between the two groups regarding the mean score of breast pain after the intervention (p=0.2).
Conclusion: The effect of oral vitamin B6 compared to placebo is not effective on reducing breast pain score in the first trimester of pregnancy. Further studies with a larger sample size, different doses of vitamin B6 and measuring the serum level of vitamin B6 are suggested.

کلیدواژه‌ها [English]

  • Breast pain
  • Pregnancy
  • Vitamin B6

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مجله زنان، مامایی و نازایی ایران
دوره 26، شماره 9
آذر 1402
صفحه 63-73

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