عوامل مرتبط با باقی ماندن مارژین مثبت بعد از انجام مخروط‌برداری سرویکس

نوع مقاله : اصیل پژوهشی

نویسندگان

1 دانشیار گروه زنان و مامایی، دانشکده پزشکی، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران.

2 دستیار گروه زنان و مامایی، دانشکده پزشکی، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران.

چکیده

مقدمه: ادامه­ بیماری بعد از عمل مخروط­ برداری سرویکس، امری محتمل است. شناخت عوامل خطر دخیل در آن، می­ تواند انتخاب شیوه­های درمانی و پیگیری مناسب را تسهیل سازد؛ بنابراین مطالعه­ حاضر با هدف تعیین عوامل مرتبط با باقی­ ماندن مارژین مثبت بعد از مخروط ­برداری سرویکس انجام گرفت.
روش‌کار: در این مطالعه تحلیلی- مقطعی گذشته­ نگر، پرونده­ های بالینی تمامی زنان بیشتر یا مساوی 18 سال مبتلا به نئوپلازی اینترا- اپی­تلیال (CIN) نوع 3 تحت عمل مخروط­ برداری سرویکس در بیمارستان امام حسین (ع) تهران (1401-1396)، به روش تمام­ شماری انتخاب و عوامل مرتبط با وضعیت مارژین داخلی پس از انجام عمل مخروط­ برداری سرویکس بررسی شد. تجزیه و تحلیل داده ­ها با استفاده از نرم ­افزار آماری SPSS (نسخه­ 23) و آزمون‌های آماری تی و من­ویتنی انجام شد. میزان p کمتر از 05/0 معنی­ دار در نظر گرفته­ شد.
یافته ­ها: در این مطالعه 100 نفر مورد بررسی قرار گرفتند که مارژین مثبت در 27 نفر (0/27%) وجود داشت. ابتلاء به پاپیلوویروس انسانی (HPV) (810/1=OR، 74/2-031/0=CI 95% و 001/0=p)، سن بالا (630/0=OR، 02/1-053/0=CI 95% و 002/0=p) و وجود یائسگی (815/0=OR، 32/1-040/0=CI 95% و 004/0=p)، به ­ترتیب با بالاترین شانس، احتمال بروز مارژین مثبت پس از عمل مخروط­برداری سرویکس را افزایش داده ­بود.
نتیجه­ گیری: سن بالا، یائسگی و ابتلاء به HPV، از جمله عوامل خطر مارژین مثبت بعد از مخروط­ برداری سرویکس هستند.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

The factors related to the remaining positive margin after cervical conization

نویسندگان [English]

  • Tahereh Ashraf Ganjouee 1
  • Mina Khoddam 2
1 Associate Professor, Department of Obstetrics and Gynecology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2 Resident, Department of Obstetrics and Gynecology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
چکیده [English]

Introduction: Continuation of the disease after cervical conization is probable. Knowing the risk factors involved can facilitate the selection of treatment methods and appropriate follow-up; therefore, this study was conducted with aim to determine the factors related to the remaining positive margin after cervical conization.
Methods: In this retrospective cross-sectional analytical study, the clinical records of all women ≥ 18 years with intra-epithelial neoplasia (CIN) type 3 who underwent cervical conization in Imam Hossein (A) Hospital of Tehran (2017-2022) were selected by total population sampling and effective factors on the condition of the internal margin after cervical conization were investigated. The data was analyzed by SPSS software (version 23) and t and Mann-Whitney statistical tests. P<0.05 was considered statistically significant.
Results: In this study, 100 people were investigated that a positive margin was found in 27 people (0.27%). Human papillovirus (HPV) infection (OR = 1.810, 95% CI = 0.071-2.74, P = 0.001), old age (OR = 0.630, 95% CI = 0.092-1.02, P = 0.002) and menopause (OR = 0.815, 95% CI = 0.096-1.32, P = 0.004), respectively with the highest chance had increased the possibility of a positive margin after cervical conization.
Conclusion: Old age, menopause and HPV infection are among the risk factors of positive margin after cervical cone removal.

کلیدواژه‌ها [English]

  • Cervical conization
  • Cervix
  • Margin

مراجع

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مجله زنان، مامایی و نازایی ایران
دوره 27، شماره 1
فروردین 1403
صفحه 1-8

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