بررسی تأثیر میزوپروستول با و بدون روغن گل‌مغربی بر سیر لیبر و نمره آپگار نوزاد در حاملگیهای پس از موعد: یک مطالعه کارآزمایی بالینی

نوع مقاله : اصیل پژوهشی

نویسندگان

1 مربی گروه مامایی، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی کردستان، سنندج، ایران.

2 دانشیار گروه مامایی، مرکز تحقیقات مراقبت‌های بالینی، پژوهشکده توسعه سلامت، دانشگاه علوم پزشکی کردستان، سنندج، ایران.

چکیده

مقدمه: یکی از علل احتمالی حاملگی‌های پس از موعد، آماده نبودن دهانه رحم می‌باشد. مطالعه حاضر با هدف مقایسه تأثیر میزوپروستول و روغن گل مغربی بر سیر لیبر و نمره آپگار نوزاد در حاملگی‌های پس از موعد انجام شد.
روش‌کار: این مطالعه کارآزمایی بالینی تصادفی‌سازی شده دوسوکور در سال 1397 بر روی 130 زن باردار با حاملگی پس از موعد انجام شد. نمونه­ها به‌روش نمونه‌گیری در دسترس انتخاب و با روش تصادفی به دو گروه گل مغربی و میزوپروستول) و (پلاسبو و میزوپروستول) تخصیص یافتند. جهت جمع­آوری داده­ ها از چک‌لیست اطلاعات دموگرافیک، بالینی همراه با سؤالات مرتبط با نمره بیشاپ، طول مدت لیبر و آپگار نوزاد استفاده شد. تجزیه و تحلیل داده ­ها با استفاده از نرم‌افزار آماری SPSS (نسخه 21) و آزمون‌های آماری کای دو، تست دقیق فیشر، تی‌تست مستقل انجام شد. میزان p کمتر از 05/0 معنی‌دار در نظر گرفته شد.
یافته­ ها: میانگین نمره بیشاپ در گروه گل مغربی و میزوپروستول در مقایسه با گروه پلاسبو و میزوپروستول افزایش معنی‌داری داشت (0001/0=p). همچنین در گروه گل مغربی و میزوپروستول در مقایسه با گروه پلاسبو و میزوپروستول طول مرحله نهفته لیبر کوتاه‌تر بود. اما بر اساس نتایج آزمون آماری کای دو، بین دو گروه از نظر نمره آپگار دقیقه اول و پنجم اختلاف معناداری وجود نداشت (05/0p>).
نتیجه­ گیری: استفاده از کپسول واژینال روغن گل مغربی در کنار میزوپروستول در مقایسه با میزوپروستول به‌تنهایی ضمن کمک به آمادگی دهانه رحم، در کاهش طول مدت مرحله نهفته لیبر موثر خواهد بود و بر روی نمره آپگار نوزاد اثر سوئی ندارد.

کلیدواژه‌ها

عنوان مقاله [English]

The effect of misoprostol with and without evening primrose oil on labor progress and neonatal Apgar score in post-term pregnancies: a clinical trial study

نویسندگان [English]

  • Soma Bahmani 1
  • Roonak Shahoei 2
1 Lecturer, Department of Midwifery, School of Nursing and Midwifery, Kurdistan University of Medical Sciences, Sanandaj, Iran.
2 Associate Professor, Department of Midwifery, Clinical Care Research Center, Health Development Research Institute, Kurdistan University of Medical Sciences, Sanandaj, Iran.
چکیده [English]

Introduction: One of the possible causes of post-term pregnancies is the unripe cervix. The present study was performed with aim to compare the effect of misoprostol and evening primrose oil on labor progress and neonatal Apgar score in post-term pregnancies.
Methods: This double-blind randomized clinical trial study was conducted in 2018 on 130 pregnant women with post-term pregnancy. The samples were selected by convenience sampling method and randomly assigned to two groups: (evening primrose and misoprostol) and (placebo and misoprostol). To collect the data, a checklist of demographic and clinical information was used along with questions related to bishop score, duration of labor and neonatal Apgar score. Data analysis was done using SPSS statistical software (version 21) and chi-square test, Fisher exact test and independent t-test. P< 0.05 was considered statistically significant.
Results: The mean bishop score in the evening primrose and misoprostol group significantly increased compared to the placebo and misoprostol group (p=0.0001). Also, the length of the latent phase of labor was shorter in the evening primrose and misoprostol group compared to the placebo and misoprostol group. However, based on the results of the chi-square test, there was no significant difference between the two groups in terms of first and fifth minutes Apgar scores (p>0.05).
Conclusion: The use of evening primrose oil vaginal capsule along with misoprostol, compared to misoprostol alone, while helping to prepare the cervix, will be effective in reducing the duration of the latent phase of labor and has no adverse effect on the neonatal Apgar score.

کلیدواژه‌ها [English]

  • Apgar score
  • Cervical Ripening
  • Evening primrose oil
  • Labor
  • Post-term pregnancy

مراجع

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مجله زنان، مامایی و نازایی ایران
دوره 26، شماره 3
خرداد 1402
صفحه 43-52

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