بررسی میزان شیوع خودایمنی تیروئید در زنان مبتلا به سندرم تخمدان پلی‌کیستیک: یک بررسی سیستماتیک و متاآنالیز

نوع مقاله : مروری

نویسندگان

1 کارشناس ارشد فیزیولوژی پزشکی، دانشکده پزشکی، دانشگاه علوم پزشکی جندی‌ شاپور، اهواز، ایران.

2 کارشناس ارشد ژنتیک، دانشکده علوم، دانشگاه شهید چمران، اهواز، ایران.

3 کارشناس ارشد بیوشیمی، دانشکده شیمی، دانشگاه کاشان، کاشان، ایران.

4 دکتری تخصصی فیزیولوژی پزشکی، کمیته تحقیقات دانشجویی، دانشگاه علوم پزشکی جندی‌ شاپور، اهواز، ایران.

چکیده

مقدمه: سندرم تخمدان پلی‌کیستیک (PCOS) یکی از شایع‌ترین بیماری‌های غدد درون‌ریز زنان است که احتمالاً با برخی بیماری‌های خودایمنی نظیر خودایمنی تیروئید (AIT) ارتباط دارد. مطالعه حاضر با هدف برآورد میزان شیوع AIT در زنان مبتلا به PCOS، به روش مرور سیستماتیک و متاآنالیز انجام شد.
روش‌کار: مطالعه مروری حاضر بر اساس چک‌لیست موارد ترجیحی در گزارشات مقالات مروری نظام‌مند و فراتحلیل (PRISMA) انجام شد. مستندات پژوهش با جستجو در پایگاه‌های اطلاعاتی فارسی ‌زبان از جمله Iranmedex، SID، Magiran و پایگاه‌های انگلیسی ‌زبان Scopus، Pubmed، Web of science و موتور جستجوگر Google Scholar از تاریخ 1 ژانویه تا 1 آگوست 2022 گردآوری شدند. تمام مستندات مرور شده در 4 سطح انتخاب، مقایسه، مواجهه و نتیجه توسط چک‌لیست Newcastle-Ottawa مورد ارزیابی کیفی واقع شدند. تجزیه ‌و تحلیل داده‌‌ها با استفاده از نرم‌افزار متاآنالیز جامع (CMA) (نسخه 1/3) انجام شد.
یافته ­ها: در مجموع 9 مطالعه با حجم 2290 فرد شرکت‌کننده وارد متاآنالیز شدند. میزان شیوع AIT در افراد مبتلا به PCOS برابر 4/26% (2/32-3/21:CI 95%) و در زنان سالم 7/11% (7/16-1/8:CI 95%) برآورد گردید. مطالعات زیرگروهی شیوع بیشتر AIT را در مبتلایان جوان‌تر گزارش ‌دادند. هم‌چنین، تحلیل فرارگرسیون نشان داد که بین منطقه مورد مطالعه با شیوع بیماری AIT ارتباط معناداری وجود دارد.
نتیجه ­گیری: ارتباط معناداری در افزایش میزان شیوع AIT میان بیماران مبتلا به PCOS وجود دارد. این موضوع اهمیت ارزیابی و پایش عملکرد تیروئید را در افراد مبتلا به PCOS نشان می‌دهد.

کلیدواژه‌ها

عنوان مقاله [English]

Prevalence of autoimmune thyroiditis in women with polycystic ovary syndrome: a systematic review and meta-analysis

نویسندگان [English]

  • Seyed Sobhan Bahreiny 1
  • Mohammad Reza Dabbagh 2
  • Reza Ebrahimi 3
  • Elnaz Harooni 4
1 M.Sc. in Medical Physiology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
2 M.Sc. in Genetics, School of Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
3 M.Sc. in Biochemistry, School of Chemistry, University of Kashan, Kashan, Iran.
4 Ph.D. in Medical Physiology, Student Research Committee, Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran.
چکیده [English]

Introduction: Polycystic ovary syndrome (PCOS) is one of the women's most common endocrine disorders, which may be is associated with some autoimmune diseases such as autoimmune thyroiditis disorders (AIT). This study was performed with aim to evaluate the prevalence of autoimmune thyroiditis in women with PCOS by a systematic review and meta-analysis.
 Methods: This review study was performed based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist. The research documents were collected by searching Persian-language databases such as Magiran, Sid, Iranmedex, and English-language databases such as Web of Science, Pubmed Scopus, and Google Scholar from January 1 until August 1, 2022. All studies were evaluated by the Newcastle-Ottawa scale at the four levels of selection, comparison, exposure, and outcome. Data analysis was performed with comprehensive meta-analysis (CMA) software (version 3.1).
 Results: A total of 9 studies with 2290 participants were included in the meta-analysis. The prevalence of AIT in patients with polycystic ovary syndrome was 26.4% (95% CI: 21.3-32.2) and in healthy women was 11.7% (95% CI: 8.1-16.7). Subgroup studies demonstrated a higher prevalence of AIT in younger patients. Meta-regression analysis also showed a significant association between the study area and the prevalence of AIT.
 Conclusion: There is a significant association between the increased prevalence of AIT in patients with PCOS. This shows the importance of evaluating and monitoring thyroid function in patients with PCOS.

کلیدواژه‌ها [English]

  • Meta-analysis
  • Polycystic ovary syndrome
  • Systematic review
  • Thyroid autoimmune

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مجله زنان، مامایی و نازایی ایران
دوره 26، شماره 1
فروردین 1402
صفحه 94-106

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