بررسی ارتباط سرب با سرطان پستان: مرور نظام‌مند

نوع مقاله : مروری

نویسندگان

1 دانشجوی دکترای بهداشت باروری، کمیته تحقیقات دانشجویی، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران.

2 دانشیار گروه مامایی و بهداشت باروری، مرکز تحقیقات مامایی و بهداشت باروری، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران.

چکیده

مقدمه: احتمال انباشت بیشتر فلزات آلاینده محیطی به‌دلیل سطوح پایین‌تر آهن در بدن زنان وجود دارد. نتایج متفاوتی مبنی بر ارتباط سرب با سرطان پستان گزارش شده است، لذا جهت تجمیع دانش موجود، مطالعه مرور سیستماتیک حاضر با هدف بررسی ارتباط سرب با سرطان پستان انجام شد.
روش‌کار: در این مطالعه مروری جهت یافتن مقالات مرتبط، پایگاه­ های اطلاعاتی بین‌المللی (Web of Science، Embase، Scopus، Google Scholar و PubMed) و ملی (Irandoc، Magiran، SID و IranMedex) با ترکیبات مختلف کلمات کلیدی مرتبط با "سرب" (Lead) و "سرطان پستان" (Breast Cancer) به‌دست آمده از MESH از سال 2022-2000 مورد بررسی قرار گرفتند. انتخاب مقالات بر اساس معیارهای ورود و خروج و ارزیابی کیفیت مقالات با استفاده از مقیاس نیوکاسل اوتاوا انجام شد..
یافته­ ها: از 4057 مقاله بررسی شده، 13 مقاله کیفیت مناسب داشتند. تمامی مطالعات به زبان انگلیسی و از نوع مشاهده­ای بودند. بر اساس اکثر مطالعات، سطح سرمی سرب با بروز سرطان پستان ارتباط نداشت، اما سطح سرب در استخوان و بافت پستان و همچنین مواجهه با سرب به‌عنوان آلاینده محیطی با بروز سرطان پستان در ارتباط بود.
نتیجه­ گیری: راه­ های متفاوت مواجه با سرب، منجر به نتایج متفاوتی شده است و به‌طور قطعی نمی‌توان گفت مواجهه با سرب، سبب بروز سرطان پستان می­ گردد، در حالی‌که این ارتباط به روش اندازه‌گیری سرب نیز بستگی دارد. در این راستا انجام مطالعات طولانی‌مدت با اندازه‌گیری دقیق سرب محیطی و بافت­ های بدن به‌خصوص برای زنان با عامل خطر بیشتر پیشنهاد می­ گردد.

کلیدواژه‌ها

عنوان مقاله [English]

The relationship between lead and breast cancer: A systematic review

نویسندگان [English]

  • Elnaz Haji Rafiei 1
  • Maryam Sadat Khalili 1
  • Marjan Havaei 1
  • Fereshteh Ghahremani 1
  • Leila Alizadeh 1
  • Mahrokh Dolatian 2
  • Giti Ozgoli 2
1 PhD Student in Reproductive Health, Student Research Committee, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2 Associate professor, Department of Midwifery and Reproductive Health, Midwifery and Reproductive Health Research Center, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
چکیده [English]

Introduction: There is a possibility of more accumulation of environmental pollutants due to lower levels of iron in the body of women. Different results have been reported on the association of lead with breast cancer, therefore, this systematic review study was performed with aim to determine the relationship between lead and breast cancer.
Methods: In this review study, to find the related articles, international databases (Web of Science, Embase, Scopus, Google Scholar and PubMed) and national (Irandoc, Magiran, SID and IranMedex) were searched with different keyword combinations related to "Lead" And "Breast Cancer" obtained from MESH in 2000 to 2022. Selection of articles was based on inclusion and exclusion criteria and articles' quality was assessed using the Newcastle Ottawa scale.
Results: Out of 4057 articles reviewed, 13 articles had good quality. All studies were in English and were observational. According to most studies, serum lead levels were not associated with breast cancer, but lead levels in bone and breast tissue were also associated with exposure to lead as an environmental contaminant with breast cancer.
Conclusion: Different ways of exposure to lead have led to different results and it cannot be certainty said that exposure to lead causes breast cancer, while this relationship also depends on the method of measuring lead. In this regard, long-term studies with accurate measurement of environmental lead and body tissues, especially for women at higher risk are recommended.

کلیدواژه‌ها [English]

  • Breast cancer
  • Environmental pollutants
  • Lead
  • Systematic review

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مجله زنان، مامایی و نازایی ایران
دوره 25، شماره 10
دی 1401
صفحه 107-117

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