بررسی تأثیر تجویز مرکب دو داروی شربت تونیک عنصلی و کپسول صمغ (فرآورده‌های طب ایرانی) بر علائم بالینی و آزمایشگاهی زنان مبتلا به سندرم تخمدان پلی‌کیستیک (مطالعه پایلوت)

نوع مقاله : اصیل پژوهشی

نویسندگان

1 مرکز تحقیقات طب سنتی و مفردات پزشکی، دانشکده طب سنتی، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران. دانشیار گروه طب سنتی، دانشکده طب سنتی، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران.

2 مرکز تحقیقات طب سنتی و مفردات پزشکی، دانشکده طب سنتی، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران. دکترای تخصصی طب سنتی، دانشکده طب سنتی، دانشگاه علوم پزشکی قم، قم، ایران.

3 دانشیار گروه طب سنتی، دانشکده طب سنتی، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران.

4 کارشناس ارشد مامایی، دانشگاه علوم پزشکی جندی شاپور، اهواز، ایران.

چکیده

مقدمه: سندرم تخمدان پلی‌کیستیک (PCOS) شایع‌ترین علت اولیگوآمنوره و عدم تخمک‫ گذاری در زنان مراجعه کننده با ناباروری است. مطالعه حاضر با هدف تعیین تأثیر تجویز مرکب دو داروی شربت تونیک عنصلی و کپسول صمغ بر علائم بالینی و آزمایشگاهی زنان مبتلا به PCOS انجام شد.
روش‌کار: این مطالعه پایلوت، مطالعه قبل و بعد بدون گروه کنترل در سال 1398 بر روی 20 زن 45-17 ساله مبتلا به PCOS با شکایت اصلی اولیگومنوره در سلامت کده طب ایرانی دانشگاه علوم پزشکی شهید بهشتی انجام شد. بیماران به‌مدت 2 ماه شربت تونیک عنصلی و کپسول صمغ دریافت کردند. شاخص ­های تن­ سنجی، ضخامت آندومتر، اندازه تخمدان‌ها، بررسی هورمونی، تعداد قاعدگی در ماه، مدت زمان قاعدگی و حجم خونریزی قاعدگی در آغاز و انتهای مطالعه ارزیابی و مقایسه شد. تجزیه و تحلیل داده‌ها با استفاده از نرم‌افزار آماری SPSS (نسخه 23) و آزمون‌های تی زوجی و ویلکاکسون انجام شد. میزان p کمتر از 05/0 معنادار در نظر گرفته شد.
یافته ­ها: در بررسی شاخص توده بدنی، توده چربی بدن، نسبت دور کمر به لگن، ضخامت آندومتر، اندازه تخمدان چپ، FSH و LH در مقایسه قبل و بعد از درمان اختلاف معنادار نبود (05/0<p). اندازه تخمدان راست و میزان تستوسترون با درمان به‌طور معنادار کاهش داشت (02/0=p). تعداد پریود در ماه از 18/0±35/0 به‌طور معناداری به 18±92/0 افزایش یافت (00/0=p). همچنین طول مدت پریود از 43/2±53/7 روز به 17/3±05/4 روز کاهش یافت که معنادار بود (00/0=p). حجم خونریزی قاعدگی از 28/15±40/33 سی‫ سی به 05/10±07/31 سی‫ سی کاهش یافت که معنادار نبود (368/0=p).
نتیجه ­گیری: با توجه به تأثیرگذاری تجویز مرکب فرآورده‫ های طب ایرانی (شربت تونیک عنصلی و کپسول صمغ) به‌نظر می‫ رسد کاربرد این فرآورده‫ ها در کنترل علائم PCOS اثر داشته باشد. لازم است مطالعات جامع آتی با حجم نمونه بیشتر و زمان ارزیابی طولانی‏ تر انجام شود.

کلیدواژه‌ها

عنوان مقاله [English]

The effect of combined administration of Onsoli syrup and Samgh capsule (Persian Medicine Products) on clinical and laboratory symptoms in women with polycystic ovary syndrome (A pilot study)

نویسندگان [English]

  • Mojgan Tansaz 1
  • Maryam Bahman 2
  • Roshanak Mokaberinejad 3
  • Samira Adhami 4
  • Rasool Choopani 1
1 Traditional Medicine & Matria Medica Research Center, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Associate Professor, Department of Traditional Medicine, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2 Traditional Medicine & Matria Medica Research Center, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Ph.D of Traditional Medicine, School of Traditional Medicine, Qom University of Medical Sciences, Qom, Iran.
3 Associate Professor, Department of Traditional Medicine, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
4 M.Sc. of Midwifery, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
چکیده [English]

Introduction: Polycystic ovary syndrome (PCOS) is the most common cause of oligomenorrhea and anovulation in women referring with infertility. The present study was performed aimed to investigate the effect of combined administration of Onsoli syrup and Samgh capsule on clinical and laboratory symptoms in women with PCOS.
Methods: This pilot study is a pre-and post-clinical study without control group which was performed in 2019 on 20 women aged 17-45 years with PCOS complaining of oligomenorrhea in Persian Medicine Clinic of Shahid Beheshti University of Medical Sciences. Samgh capsule and Tonic Onsoli syrup were used for two months. Anthropometric indexes, endometrial thickness, ovarian size, hormonal evaluation, number of menstruation per month, menstrual duration, and volume of menstruation bleeding were evaluated and compared at the beginning and end of the study. Data were analyzed by SPSS software (version 23) and paired t-test and Wilcoxon test. P<0.05 was considered statistically significant.
Results: There was no significant difference in body mass index, body fat mass, waist to hip ratio, endometrial thickness, left ovarian size, FSH, LH before and after treatment (p>0.05). The size of the right ovary and testosterone levels significantly deceased after treatment (p=0.02). The number of menstruation per month significantly increased from 0.35±0.18 to 0.92±18 (p=0.00). Also, the duration of menstruation significantly decreased from 7.53±2.43 days to 4.05±3.17 days (p=0.00). The volume of mensuration bleeding decreased from 33.40±15.28 ml to 31.07±10.05 ml, which was not significant (p=0.368).
Conclusion: Due to the effectiveness of combined administration of Persian medicine products (Onsoli syrup and Samgh capsule), it seems that the use of these products is effective in controlling of the symptoms of PCOS. It is necessary to conduct future studies with a larger sample size and longer evaluation time.

کلیدواژه‌ها [English]

  • Iranian medicine
  • Mensuration
  • Onsol
  • Polycystic ovary syndrome
  • Samgh

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مجله زنان، مامایی و نازایی ایران
دوره 25، شماره 9
آذر 1401
صفحه 1-10

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