بررسی یافته‌های آزمایشگاهی و بالینی زنان باردار بستری مبتلا به کووید-19 در زمان شیوع واریانت دلتا بر اساس پیامد بیماری در استان اردبیل (تابستان و پاییز 1400)

نوع مقاله : اصیل پژوهشی

نویسندگان

1 استادیار گروه زنان و مامایی، دانشکده پزشکی، دانشگاه علوم پزشکی اردبیل، اردبیل، ایران.

2 رزیدنت گروه زنان و مامایی، دانشکده پزشکی، دانشگاه علوم پزشکی اردبیل، اردبیل، ایران.

3 استاد گروه عفونی، دانشکده پزشکی، دانشگاه علوم پزشکی اردبیل، اردبیل، ایران.

4 استادیار گروه فیزیولوژی و فارماکولوژی، مرکز تحقیقات بیماری ریوی، دانشگاه علوم پزشکی اردبیل، اردبیل، ایران.

5 استادیار گروه مامایی، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی اردبیل، اردبیل، ایران.

چکیده

مقدمه: با توجه به خطر بالای بیماری کووید-19 به‌خصوص سویه دلتا در زنان باردار و همچنین جدید بودن این همه‌گیری در جهان و کمبود مطالعات مشابه در ایران و منطقه، انجام مطالعه در خصوص میزان مرگ­و­میر و یافته‌های آزمایشگاهی و بالینی بیماری در زنان باردار ضروری به‌نظر می ­رسد، لذا مطالعه حاضر با هدف تعیین یافته‌های آزمایشگاهی و بالینی زنان باردار بستری مبتلا به کووید-19 در زمان شیوع واریانت دلتا بر اساس پیامد بیماری انجام شد.
روش‌کار: در این مطالعه توصیفی- مقطعی تمام زنان باردار مبتلا به کووید-19 بستری در بیمارستان­ های استان اردبیل در تابستان و پاییز 1400 و در زمان شیوع سویه دلتا وارد مطالعه شدند. در نهایت 187 زن باردار مبتلا مورد مطالعه قرار گرفتند. اطلاعات دموگرافیک، علائم بالینی و یافته­ های آزمایشگاهی در تمام افراد مورد مطالعه مورد بررسی قرار گرفت. تجزیه و تحلیل داده‌ها با استفاده از نرم‌افزار SPSS (نسخه 24) و آزمون‌های دقیق فیشر و همبستگی پیرسون انجام شد. میزان p کمتر از 05/0 معنی­ دار در نظر گرفته شد.
یافته ­ها: از 187 زن باردار مبتلای بستری شده، 8 نفر فوت شدند. ابتلاء به بیماری­ های زمینه­ ای در 41 زن باردار مشاهده شد. شایع‌ترین یافته بالینی، تنگی نفس و سرفه و شایع‌ترین یافته آزمایشگاهی، لنفوپنی بود. در مقایسه زنان باردار بهبود یافته و فوت شده برحسب یافته‌های آزمایشگاهی با استفاده از آزمون دقیق فیشر، تفاوت بین میزان ALT (05/0p<)، لاکتات دهیدروژناز (001/0p<)، AST (001/0p<)، BS (05/0p<)، کراتنین (05/0p<) و توتال بیلی‌روبین (05/0p<) بین دو گروه از نظر آماری معنی‌دار بود.
نتیجه ­گیری: ابتلاء به سویه دلتا از بیماری کووید-19، منجر به بستری شدن 187 نفر و فوت 8 زن باردار در استان اردبیل شد. تنگی نفس و سرفه، شایع‌ترین یافته بالینی و لنفوپنی، شایع‌ترین یافته آزمایشگاهی بود.

کلیدواژه‌ها

عنوان مقاله [English]

Laboratory and clinical findings in hospitalized pregnant women with Covid-19 based on disease outcome during the outbreak of Delta variant in Ardabil (summer and autumn 2021)

نویسندگان [English]

  • Shahla Farzipour 1
  • Faranak Shojaei 2
  • Shahram Habibzadeh 3
  • Mohammad Reza Aslani 4
  • Samira Shahbazzadegan 5
1 Assistant Professor, Department of Obstetrics and Gynecology, Faculty of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.
2 Resident, Department of Obstetrics and Gynecology, Faculty of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.
3 Professor, Department of Infection, Faculty of Medicine, Ardabil University of Medical Science, Arabil, Iran.
4 Assistant Professor, Department of Physiology and Pharmacology, Lung Diseases Research Center, Ardabil University of Medical Sciences, Arabil, Iran.
5 Assistant Professor, Department of Midwifery, School of Nursing and Midwifery, Ardabil University of Medical Sciences, Ardabil, Iran.
چکیده [English]

Introduction: Due to the high risk of Covid-19 disease, especially delta variant in pregnant women, as well as the novelty of this epidemic in the world and the lack of similar studies in Iran and the region, it seems necessary to perform a study on mortality rate and laboratory and clinical findings of the disease in pregnant women. Therefore, this study was performed aimed to determine the laboratory and clinical findings in hospitalized pregnant women with Covid -19 based on disease outcome during the outbreak of Delta variant (summer and autumn 2021) in Ardabil province.
Methods: In this cross-sectional and descriptive study, all pregnant women with Covid-19 admitted to the hospitals of Ardabil province in summer and autumn 2021 at the time of delta outbreak were included. Finally, 187 infected pregnant mothers were studied. Demographic information, clinical signs and laboratory findings were studied in all mothers. Data were analyzed by SPSS (version 24) and Fisher Exact test and Pearson Correlation. P<0.05 was considered statistically significant.
Results: Of the 187 infected pregnant women, 8 mothers died. Comorbidity was observed in 41 pregnant women. The most common clinical finding was shortness of breath (Dyspnea) and cough, and the most common laboratory finding was lymphopenia. Comparing the cured and dead mothers according to laboratory findings using Fisher's exact test showed that the difference between ALT (p <0.05), lactate dehydrogenase (p <0.001), AST (p <0.001), BS (P <0.05), creatinine (p <0.05) and total bilirubin (p<0.05) were statistically significant between the two groups.
Conclusion: Infection to delta variant of Covid-19 disease resulted in 187 hospitalizations and 8 deaths of pregnant mothers in Ardabil province. Shortness of breath (Dyspnea) and cough were the most common clinical findings and lymphopenia was the most common laboratory finding.

کلیدواژه‌ها [English]

  • Cough
  • COVID-19
  • Dyspnea
  • Lymphopenia
  • Pregnant Women
  • SARS-CoV-2 B.1.621.1 variant

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مجله زنان، مامایی و نازایی ایران
دوره 25، شماره 9
آذر 1401
صفحه 29-39

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