ارتباط سطح سرمی ویتامین D با ابتلاء و شدت علائم بیماری کووید-19 در زنان و کودکان: یک مطالعه مرور سیستماتیک

نوع مقاله : مروری

نویسندگان

1 دانشجوی کارشناسی علوم تغذیه، کمیته تحقیقات دانشجویی، دانشکده پزشکی، دانشگاه علوم پزشکی زاهدان، زاهدان، ایران.

2 دانشجوی کارشناسی ارشد مامایی، مرکز تحقیقات توسعه اجتماعی و ارتقاء سلامت، دانشکده پزشکی، دانشگاه علوم پزشکی گناباد، گناباد، ایران.

چکیده

مقدمه: سطح سرمی ویتامین D بر ابتلاء و تشدید علائم بیماری کووید-19 در چندین مطالعه بیان شده و قابل بحث است. مطالعه حاضر با هدف مرور سیستماتیک بر مطالعات انجام شده در زمینه تعیین ارتباط سطح سرمی ویتامین D با ابتلاء و شدت علائم بیماری کووید-19 در زنان و کودکان انجام شد.
روش‌کار: در این مطالعه مرور سیستماتیک جهت دستیابی به مطالعات مرتبط، پایگاه‌های اطلاعاتی انگلیسی Pubmed، Scopus و Web of science تا 4 آوریل 2021 با کلیدواژه‌های انگلیسی ویتامین D و کووید-19 با ترکیبات عملگرهای AND و OR جستجو شدند. معیارهای ورود به مطالعه شامل: مقالات کوهورت، مورد- شاهدی یا مقطعی، زبان انگلیسی و جمعیت مطالعه شامل زنان و یا کودکان بود. ارزیابی کیفیت مقالات با استفاده از چک‌لیست استروب صورت گرفت. بر اساس معیار استروب، مطالعاتی که در ارزیابی، امتیاز متوسط و خوب را کسب کردند، وارد مطالعه شدند.
یافته­ ها: از مجموع 315 مقاله، 23 مقاله واجد شرایط بررسی شدند. در این مطالعات ارتباط سطح سرمی ویتامین D با ابتلاء، شدت و میزان مرگ‌و‌میر ناشی از کووید-19 سنجیده شده بود. 2 مطالعه جمعیت کودکان و 21 مطالعه زنان را شامل می‌شد.
نتیجه ­گیری: سطوح سرمی پایین ویتامین D به‌طور معناداری در ارتباط با افزایش میزان ابتلاء به کووید-19 و شدت بیماری است، اما این ارتباط با میزان مرگ‌و‌میر حاصل از بیماری در مطالعات متعدد نتایج ضدونقیضی را ارئه می‌دهد؛ لذا مطالعات بیشتری در این زمینه جهت دستیابی به نتایج قطعی‌تر بالاخص در کودکان ضروری است.

کلیدواژه‌ها

عنوان مقاله [English]

The relationship between serum vitamin D levels with infection and severity of Covid-19 Symptoms in women and children: A systematic review study

نویسندگان [English]

  • Rasoul Rahmani 1
  • Yeganeh Lexian 2
1 B.Sc. student of Nutrition, Student Research Committee, Faculty of Medicine, Zahedan University of Medical Sciences, Zahdan, Iran.
2 M.Sc. Student of Midwifery, Social Development and Health Promotion Research Center, Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran.
چکیده [English]

Introduction: Serum levels of vitamin D on the development and exacerbation of symptoms of Covid-19 disease have been expressed and discussed in several studies. The present study was performed aimed to systematically review the studies performed on the relationship between serum level of vitamin D with the incidence and severity of Covid-19 symptoms disease in women and children.
Methods: In this systematic review study, to obtain the related studies, the English databases of Pubmed, Scopus and Web of Science were searched up to April 4, 2021 with the English keywords of Vitamin D and Covid-19 with combination of operators "AND" and "OR". Inclusion criteria were: cohort articles, case-control or cross-sectional and English language articles and the study population were women or children. The quality of articles was assessed using the Strobe checklist. Based on the Strobe criteria, studies which scored moderate and good in the assessment were included in the study.
Results: Out of 315 articles, 23 qualified articles were reviewed. In these studies, the association between serum vitamin D levels and the incidence, severity, and mortality of Covid-19 was assessed. Two studies included the population of children and 21 studies of women.
Conclusion: Low serum levels of vitamin D are significantly associated with an increase in the incidence of Covid-19 and the severity of the disease, but this relationship with the mortality rate from the disease provides contradictory results in several studies; therefore, more studies in this field are necessary to achieve more definite results, especially in children.

کلیدواژه‌ها [English]

  • Covid - 19
  • Outcome
  • Systematic Review
  • Vitamin D

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مجله زنان، مامایی و نازایی ایران
دوره 25، شماره 8
آبان 1401
صفحه 122-135

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