ارتباط سطح سرمی ویتامین D با ابتلاء و شدت علائم بیماری کووید-19 در زنان و کودکان: یک مطالعه مرور سیستماتیک

نوع مقاله : مروری

نویسندگان

1 دانشجوی کارشناسی علوم تغذیه، کمیته تحقیقات دانشجویی، دانشکده پزشکی، دانشگاه علوم پزشکی زاهدان، زاهدان، ایران.

2 دانشجوی کارشناسی ارشد مامایی، مرکز تحقیقات توسعه اجتماعی و ارتقاء سلامت، دانشکده پزشکی، دانشگاه علوم پزشکی گناباد، گناباد، ایران.

چکیده

مقدمه: سطح سرمی ویتامین D بر ابتلاء و تشدید علائم بیماری کووید-19 در چندین مطالعه بیان شده و قابل بحث است. مطالعه حاضر با هدف مرور سیستماتیک بر مطالعات انجام شده در زمینه تعیین ارتباط سطح سرمی ویتامین D با ابتلاء و شدت علائم بیماری کووید-19 در زنان و کودکان انجام شد.
روشکار: در این مطالعه مرور سیستماتیک جهت دستیابی به مطالعات مرتبط، پایگاه‌های اطلاعاتی انگلیسی Pubmed، Scopus و Web of science تا 4 آوریل 2021 با کلیدواژه‌های انگلیسی ویتامین D و کووید-19 با ترکیبات عملگرهای AND و OR جستجو شدند. معیارهای ورود به مطالعه شامل: مقالات کوهورت، مورد- شاهدی یا مقطعی، زبان انگلیسی و جمعیت مطالعه شامل زنان و یا کودکان بود. ارزیابی کیفیت مقالات با استفاده از چک‌لیست استروب صورت گرفت. بر اساس معیار استروب، مطالعاتی که در ارزیابی، امتیاز متوسط و خوب را کسب کردند، وارد مطالعه شدند.
یافته­ ها: از مجموع 315 مقاله، 23 مقاله واجد شرایط بررسی شدند. در این مطالعات ارتباط سطح سرمی ویتامین D با ابتلاء، شدت و میزان مرگ‌و‌میر ناشی از کووید-19 سنجیده شده بود. 2 مطالعه جمعیت کودکان و 21 مطالعه زنان را شامل می‌شد.
نتیجه ­گیری: سطوح سرمی پایین ویتامین D به‌طور معناداری در ارتباط با افزایش میزان ابتلاء به کووید-19 و شدت بیماری است، اما این ارتباط با میزان مرگ‌و‌میر حاصل از بیماری در مطالعات متعدد نتایج ضدونقیضی را ارئه می‌دهد؛ لذا مطالعات بیشتری در این زمینه جهت دستیابی به نتایج قطعی‌تر بالاخص در کودکان ضروری است.

کلیدواژه‌ها


عنوان مقاله [English]

The relationship between serum vitamin D levels with infection and severity of Covid-19 Symptoms in women and children: A systematic review study

نویسندگان [English]

  • Rasoul Rahmani 1
  • Yeganeh Lexian 2
1 B.Sc. student of Nutrition, Student Research Committee, Faculty of Medicine, Zahedan University of Medical Sciences, Zahdan, Iran.
2 M.Sc. Student of Midwifery, Social Development and Health Promotion Research Center, Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran.
چکیده [English]

Introduction: Serum levels of vitamin D on the development and exacerbation of symptoms of Covid-19 disease have been expressed and discussed in several studies. The present study was performed aimed to systematically review the studies performed on the relationship between serum level of vitamin D with the incidence and severity of Covid-19 symptoms disease in women and children.
Methods: In this systematic review study, to obtain the related studies, the English databases of Pubmed, Scopus and Web of Science were searched up to April 4, 2021 with the English keywords of Vitamin D and Covid-19 with combination of operators "AND" and "OR". Inclusion criteria were: cohort articles, case-control or cross-sectional and English language articles and the study population were women or children. The quality of articles was assessed using the Strobe checklist. Based on the Strobe criteria, studies which scored moderate and good in the assessment were included in the study.
Results: Out of 315 articles, 23 qualified articles were reviewed. In these studies, the association between serum vitamin D levels and the incidence, severity, and mortality of Covid-19 was assessed. Two studies included the population of children and 21 studies of women.
Conclusion: Low serum levels of vitamin D are significantly associated with an increase in the incidence of Covid-19 and the severity of the disease, but this relationship with the mortality rate from the disease provides contradictory results in several studies; therefore, more studies in this field are necessary to achieve more definite results, especially in children.

کلیدواژه‌ها [English]

  • Covid - 19
  • Outcome
  • Systematic Review
  • Vitamin D
  1. Taheri S. A Review on Coronavirus Disease (COVID-19) and What is Known about it. Depiction of Health 2020; 11(1):87-93.
  2. Ramezani A, Amirpour M. Nutritional Care in the Prevention and Treatment of Coronavirus Disease 2019: A Simple Overview. Journal of health research in community 2020; 6(1):74-82.
  3. Zorriehzahra MJ, Dadar M, Ziarati M, Seidgar M, Hassantabar F, Ghasemi M, et al. A Perspective on the Origin of COVID-19 and Its Epidemic Situation in Iran and the World. Journal of Marine Medicine 2020; 2(1):41-52.
  4. Moaya M, Shahali S, Farhoudi B. Maternal and neonatal outcomes of pregnant women with COVID-19 in Amir-al-momenin hospital during March to May 2020. Iran J Obstet Gynecol Infertil 2020; 23(9):35-42.
  5. Nikoonejad A, Shafizadeh Arjomandi A, Dodangeh S, Allami A. Comparison of Serum Level of Vitamin D3 in Covid-19 Patients and Non-Infected Individuals. Avicenna Journal of Clinical Medicine 2021; 28(1):13-9.
  6. Khaledi S, Ahmadi S. The need to take vitamin D in prevention of COVID-19. Razi Journal of Medical Sciences 2021; 28(1):95-108.
  7. Azadeh H, Hedayatizadeh-Omran A, Saeedi M, Vahedi-Larijani L, Mehravaran H, Heydari K. Serum vitamin D concentrations in CoVID19 patients. Journal of Mazandaran University of Medical Sciences 2021; 31(195):30-6.
  8. Alizadehsani R, Alizadeh Sani Z, Behjati M, Roshanzamir Z, Hussain S, Abedini N, et al. Risk factors prediction, clinical outcomes, and mortality in COVID‐19 patients. Journal of medical virology 2021; 93(4):2307-20.
  9. Fayazi M, Rahmani R, Rahmani Bilandi R. Clinical manifestations, maternal, fetal and neonatal outcomes in pregnant women with COVID-19: A systematic review. T Iran J Obstet Gynecol Infertil 2021; 24(7):108-19.
  10. Mizrahi B, Shilo S, Rossman H, Kalkstein N, Marcus K, Barer Y, et al. Longitudinal symptom dynamics of COVID-19 infection. Nature communications 2020; 11(1):1-10.
  11. Da Silveira MP, da Silva Fagundes KK, Bizuti MR, Starck É, Rossi RC, de Resende E Silva DT. Physical exercise as a tool to help the immune system against COVID-19: an integrative review of the current literature. Clinical and experimental medicine 2021; 21(1):15-28.
  12. Gasmi A, Tippairote T, Mujawdiya PK, Peana M, Menzel A, Dadar M, et al. Micronutrients as immunomodulatory tools for COVID-19 management. Clinical Immunology 2020; 220:108545.
  13. Basu TK, Donaldson D. Intestinal absorption in health and disease: micronutrients. Best practice & research Clinical gastroenterology 2003; 17(6):957-79.
  14. Zimmermann MB. Iodine deficiency. Endocrine reviews 2009; 30(4):376-408.
  15. Junaid K, Ejaz H, Abdalla AE, Abosalif KO, Ullah MI, Yasmeen H, et al. Effective immune functions of micronutrients against SARS-CoV-2. Nutrients 2020; 12(10):2992.
  16. Kim D. The role of vitamin D in thyroid diseases. International journal of molecular sciences 2017; 18(9):1949.
  17. Rai V, Agrawal DK. Role of vitamin D in cardiovascular diseases. Endocrinology and Metabolism Clinics 2017; 46(4):1039-59.
  18. Illescas-Montes R, Melguizo-Rodríguez L, Ruiz C, Costela-Ruiz VJ. Vitamin D and autoimmune diseases. Life sciences 2019; 233:116744.
  19. White JH. Vitamin D signaling, infectious diseases, and regulation of innate immunity. Infection and immunity 2008; 76(9):3837-43.
  20. Farzipour S, Jalilvand F, Amani F, Kazemi M, Nikjou R, Shahbazzadegan S. Relationship of maternal vitamin D level with premature rupture of fetal membranes. Iran J Obstet Gynecol Infertil 2020; 23(1):33-9.
  21. Solidoro P, Bellocchia M, Facchini F. The immunobiological and clinical role of vitamin D in obstructive lung diseases. Minerva medica 2016; 107(3 Suppl 1):12-9.
  22. Urashima M, Segawa T, Okazaki M, Kurihara M, Wada Y, Ida H. Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren. The American journal of clinical nutrition 2010; 91(5):1255-60.
  23. Yisak H, Ewunetei A, Kefale B, Mamuye M, Teshome F, Ambaw B, et al. Effects of vitamin D on COVID-19 infection and prognosis: a systematic review. Risk management and healthcare policy 2021; 14:31.
  24. da Rocha AP, Atallah AN, Aldrighi JM, Pires AL, dos Santos Puga ME, Pinto AC. Insufficient evidence for vitamin D use in COVID‐19: A rapid systematic review. International journal of clinical practice 2021; 75(11):e14649.
  25. Grove A, Osokogu O, Al-Khudairy L, Mehrabian A, Zanganeh M, Brown A, T et al. Association between vitamin D supplementation or serum vitamin D level and susceptibility to SARS-CoV-2 infection or COVID-19 including clinical course, morbidity and mortality outcomes? A systematic review. BMJ open 2021; 11(5):e043737.
  26. Moher D, Shamseer L, Clarke M, Ghersi D, Liberati A, Petticrew M, et al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Systematic reviews 2015; 4(1):1-9.
  27. Von Elm E, Altman DG, Egger M, Pocock SJ, Gøtzsche PC, Vandenbroucke JP, et al. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Annals of internal medicine 2007; 147(8):573-7.
  28. Kaufman HW, Niles JK, Kroll MH, Bi C, Holick MF. SARS-CoV-2 positivity rates associated with circulating 25-hydroxyvitamin D levels. PloS one 2020; 15(9):e0239252.
  29. Meltzer DO, Best TJ, Zhang H, Vokes T, Arora V, Solway J. Association of vitamin D status and other clinical characteristics with COVID-19 test results. JAMA network open 2020; 3(9):e2019722-.
  30. Notz Q, Herrmann J, Schlesinger T, Kranke P, Sitter M, Helmer P, et al. Vitamin D deficiency in critically ill COVID-19 ARDS patients. Clinical Nutrition 2021.
  31. Pizzini A, Aichner M, Sahanic S, Böhm A, Egger A, Hoermann G, et al. Impact of vitamin D deficiency on COVID-19—a prospective analysis from the CovILD Registry. Nutrients 2020; 12(9):2775.
  32. Maghbooli Z, Sahraian MA, Ebrahimi M, Pazoki M, Kafan S, Tabriz HM, et al. Vitamin D sufficiency, a serum 25-hydroxyvitamin D at least 30 ng/mL reduced risk for adverse clinical outcomes in patients with COVID-19 infection. PloS one 2020; 15(9):e0239799.
  33. Yılmaz K, Şen V. Is vitamin D deficiency a risk factor for COVID‐19 in children?. Pediatric pulmonology 2020; 55(12):3595-601.
  34. Ye K, Tang F, Liao X, Shaw BA, Deng M, Huang G, et al. Does serum vitamin D level affect COVID-19 infection and its severity?-A case-control study. Journal of the American College of Nutrition 2021; 40(8):724-31.
  35. Luo X, Liao Q, Shen Y, Li H, Cheng L. Vitamin D deficiency is associated with COVID-19 incidence and disease severity in Chinese people. The Journal of nutrition 2021; 151(1):98-103.
  36. Kerget B, Kerget F, Kızıltunç A, Koçak A, Araz Ö, Yılmazel Uçar E, et al. Evaluation of the relationship of serum vitamin D levels in COVID-19 patients with clinical course and prognosis. Tuberkuloz Ve Torak-Tuberculosis and Thorax 2020; 68(3):227-35
  37. Adami G, Giollo A, Fassio A, Benini C, Bertoldo E, Bertoldo F, et al. Vitamin D and disease severity in coronavirus disease 19 (COVID-19). Reumatismo 2020; 72(4):189-96.
  38. Karahan S, Katkat F. Impact of serum 25 (OH) vitamin D level on mortality in patients with COVID-19 in Turkey. The journal of nutrition, health & aging 2021; 25(2):189-96.
  39. De Smet D, De Smet K, Herroelen P, Gryspeerdt S, Martens GA. Serum 25 (OH) D level on hospital admission associated with COVID-19 stage and mortality. American journal of clinical pathology 2021; 155(3):381-8.
  40. Infante M, Buoso A, Pieri M, Lupisella S, Nuccetelli M, Bernardini S, et al. Low vitamin D status at admission as a risk factor for poor survival in hospitalized patients with COVID-19: an Italian retrospective study. Journal of the American Nutrition Association 2022; 41(3):250-65.
  41. Carpagnano GE, Di Lecce V, Quaranta VN, Zito A, Buonamico E, Capozza E, et al. Vitamin D deficiency as a predictor of poor prognosis in patients with acute respiratory failure due to COVID-19. Journal of endocrinological investigation 2021; 44(4):765-71.
  42. Tehrani S, Khabiri N, Moradi H, Mosavat MS, Khabiri SS. Evaluation of vitamin D levels in COVID-19 patients referred to Labafinejad hospital in Tehran and its relationship with disease severity and mortality. Clinical nutrition ESPEN 2021; 42:313-7.
  43. Baktash V, Hosack T, Patel N, Shah S, Kandiah P, Van den Abbeele K, et al. Vitamin D status and outcomes for hospitalised older patients with COVID-19. Postgraduate medical journal 2021; 97(1149):442-7.
  44. Gavioli EM, Miyashita H, Hassaneen O, Siau E. An evaluation of serum 25-hydroxy vitamin D levels in patients with COVID-19 in New York City. Journal of the American Nutrition Association 2022; 41(2):201-6.
  45. Angelidi AM, Belanger MJ, Lorinsky MK, Karamanis D, Chamorro-Pareja N, Ognibene J, et al. Vitamin D status is associated with in-hospital mortality and mechanical ventilation: a cohort of COVID-19 hospitalized patients. InMayo Clinic Proceedings 2021; 96(4):875-86.
  46. Lohia P, Nguyen P, Patel N, Kapur S. Exploring the link between vitamin D and clinical outcomes in COVID-19. American Journal of Physiology-Endocrinology and Metabolism 2021; 320(3):E520-6.
  47. Sulli A, Gotelli E, Casabella A, Paolino S, Pizzorni C, Alessandri E, et al. Vitamin D and lung outcomes in elderly COVID-19 patients. Nutrients 2021; 13(3):717.
  48. Hernández JL, Nan D, Fernandez-Ayala M, García-Unzueta M, Hernández-Hernández MA, López-Hoyos M, et al. Vitamin D status in hospitalized patients with SARS-CoV-2 infection. The Journal of Clinical Endocrinology & Metabolism 2021; 106(3):e1343-53.
  49. Raharusun P, Priambada S, Budiarti C, Agung E, Budi C. Patterns of COVID-19 mortality and vitamin D: an Indonesian study. SSRN Electron J 2020; 7:1-2.
  50. Ling SF, Broad E, Murphy R, Pappachan JM, Pardesi-Newton S, Kong MF, et al. High-dose cholecalciferol booster therapy is associated with a reduced risk of mortality in patients with COVID-19: a cross-sectional multi-centre observational study. Nutrients 2020; 12(12):3799.
  51. Drame M, Cofais C, Hentzien M, Proye E, Coulibaly PS, Demoustier-Tampere D, et al. Relation between vitamin D and COVID-19 in aged people: a systematic review. Nutrients 2021; 13(4):1339.
  52. Chiodini I, Gatti D, Soranna D, Merlotti D, Mingiano C, Fassio A, et al. Vitamin D status and SARS-CoV-2 infection and COVID-19 clinical outcomes. Frontiers in public health 2021: 1968.
  53. Pal R, Banerjee M, Bhadada SK, Shetty AJ, Singh B, Vyas A. Vitamin D supplementation and clinical outcomes in COVID-19: a systematic review and meta-analysis. Journal of endocrinological investigation 2021; 45(1):53-68.
  54. Szarpak L, Rafique Z, Gasecka A, Chirico F, Gawel W, Hernik J, et al. A systematic review and meta-analysis of effect of vitamin D levels on the incidence of COVID-19. Cardiology journal 2021; 28(5):647-54.
  55. Akbar MR, Wibowo A, Pranata R, Setiabudiawan B. Low serum 25-hydroxyvitamin D (vitamin D) level is associated with susceptibility to COVID-19, severity, and mortality: a systematic review and meta-analysis. Frontiers in nutrition 2021; 8:660420.
  56. Beyerstedt S, Casaro EB, Rangel ÉB. COVID-19: angiotensin-converting enzyme 2 (ACE2) expression and tissue susceptibility to SARS-CoV-2 infection. European journal of clinical microbiology & infectious diseases 2021; 40(5):905-19.
  57. Kai H, Kai M. Interactions of coronaviruses with ACE2, angiotensin II, and RAS inhibitors—lessons from available evidence and insights into COVID-19. Hypertension Research 2020; 43(7):648-54.
  58. Ganji A, Mosayebi G, Khaki M, Ghazavi A. A review of the 2019 novel Coronavirus (Covid-19): Immunopathogenesis, molecular biology and clinical aspects. Journal of Arak University of Medical Sciences 2020; 23(1):8-21.
  59. Uzunova VV, Todev A, Zarkos J, Addai D, Ananiev J, Rashev P, et al. Strengthening CoViD-19 therapy via combinations of RAS modulators. Medical Hypotheses 2021; 150:110571.
  60. Brüssow H. Immunology of COVID‐19. Environmental microbiology 2020; 22(12):4895-908.
  61. Getachew B, Tizabi Y. Vitamin D and COVID‐19: Role of ACE2, age, gender, and ethnicity. Journal of Medical Virology 2021; 93(9):5285-94.