سندرم تخمدان پلی‌کیستیک و سردردهای اولیه: یک مطالعه مرور نقلی

نوع مقاله : مروری

نویسندگان

1 دکترای سلامت باروری، مرکز تحقیقات اندوکرینولوژی تولید مثل، پژوهشکده علوم غدد درون‌ریز و متابولیسم، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران.

2 کارشناس ارشد بیوتکنولوژی، مرکز تحقیقات اندوکرینولوژی تولید مثل، پژوهشکده علوم غدد درون‌ریز و متابولیسم، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران.

3 استاد، مرکز تحقیقات اندوکرینولوژی تولیدمثل، پژوهشکده علوم غدد درون‌ریز و متابولیسم، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران.

چکیده

مقدمه: سندرم تخمدان پلی­ کیستیک و سردردهای اولیه، از مشکلات شایع سلامت زنان در سراسر جهان محسوب می­ شوند. برخی شواهد حاکی از این است که این دو اختلال ممکن است برخی عوامل خطر را به اشتراک بگذارند. مطالعه مرور نقلی حاضر با هدف بررسی مسیرهای مشترک دخیل در بروز همزمان این دو اختلال انجام شد.
روش‌کار: در این مطالعه مرور نقلی، کلید واژه‌های مرتبط نظیر سندرم تخمدان پلی­ کیستیک و سردرد اولیه (میگرن، سردرد خوشه­ ای و سردرد تنشی) در پایگاه ­های اطلاعاتی PubMed، Scopus، Web of Science وGoogle Scholar با اعمال محدودیت زبان انگلیسی و بدون اعمال محدودیت زمانی تا نوامبر 2021 مورد جستجو قرار گرفتند. معیارهای ورود مقالات شامل مطالعات از نوع مشاهده‌ای، تجربی و مروری و مقالاتی که یافته­ های متناسب با اهداف این مطالعه مروری را ارائه کرده بودند. گزارش یافته­ های این مطالعه به‌صورت کیفی ارائه شد.
یافته­ ها: در این مطالعه 60 مقاله استخراج شده مورد بررسی قرار گرفت. برخی عوامل خطر و پیامدهای بالینی سندرم تخمدان پلی­کیستیک و سردردهای اولیه از جمله میگرن، مشترک است، اما تداخل احتمالی بروز همزمان این دو اختلال هنوز مشخص نشده است. شواهد متعدد حاکی از آن بود که سبک زندگی و فاکتورهای روان‌شناختی، از جمله فاکتورهای مهمی هستند که در بروز هر دو این اختلال نقش دارند. به علاوه از دیگر مسیرهای پاتولوژیک احتمالی مشترک بین این دو اختلال می­ توان به اختلالات هورمونی (هورمون­های جنسی، هورمون تیروئیدی، پرولاکتین)، فاکتورهای خطر مربوط به اختلالات متابولیک (مقاومت به انسولین، فشارخون بالا، اختلال لیپیدی)، چاقی و فاکتورهای التهابی اشاره کرد.
نتیجه ­گیری: شواهد در دسترس به‌طور عمده بیانگر مسیرهای مشترک از جمله اختلالات هورمونی، متابولیک و التهابی در بروز سندرم تخمدان پلی­ کیستیک و سردرد­های اولیه از جمله میگرن هستند. 

کلیدواژه‌ها

عنوان مقاله [English]

Polycystic Ovary Syndrome and Primary Headaches: A Narrative Review Study

نویسندگان [English]

  • Marzieh Saei Gharenaz 1
  • Mahbanoo Farhadi Azar 2
  • Fahimeh Ramezani Tehrani 3
1 PhD of Reproductive Health, Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences and Metabolism, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2 M.Sc. of Biotechnology, Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences and Metabolism, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
3 Professor, Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences and Metabolism, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
چکیده [English]

Introduction: Polycystic ovary syndrome and primary headaches are common health problems in women around the world. Some evidence indicates that these two disorders may share some risk factors. This narrative review study was performed aimed to investigate the common pathways involved in the simultaneous occurrence of these two disorders.
Methods: In this narrative review study, the relevant keywords such as polycystic ovary syndrome and primary headache (migraine, cluster headache and tension headache) were searched in databases of PubMed, Scopus, Web of Science, and Google Scholar with English language limitation and no time limit until Nov 2019. Inclusion criteria were observational, experimental, and review studies, and the articles which presented findings appropriate to the objectives of this review study. Findings of this study were presented qualitatively.
Results: In this study, 60 extracted articles were assessed. Polycystic ovary syndrome and primary headaches like migraine have some common risk factors and clinical consequences, but the possible overlap between these two disorders has not yet been identified. Numerous evidences have suggested that lifestyle and psychological factors are important factors that contribute in the development and progression of both disorders. In addition, other possible common pathological pathways include hormonal disorders (sex hormones, thyroid hormone, and prolactin), risk factors for metabolic abnormalities (insulin resistance, hypertension, and lipid disorder), obesity, and inflammatory factors.
Conclusion: The available evidence mainly indicates common pathways including hormonal, metabolic, and inflammatory abnormality in the development of polycystic ovary syndrome and primary headaches including migraine.

کلیدواژه‌ها [English]

  • Migraine
  • Polycystic ovary syndrome
  • Primary headache
  • Review

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مجله زنان، مامایی و نازایی ایران
دوره 25، شماره 8
آبان 1401
صفحه 94-108

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