بررسی تأثیر ژل واژینال افسنطین بر افسردگی زنان سنین باروری دارای اختلال عملکرد جنسی: یک کارآزمایی بالینی تصادفی کنترل شده

نوع مقاله : اصیل پژوهشی

نویسندگان

1 دانشجوی کارشناسی ارشد مامایی، کمیته تحقیقات دانشجویی، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی مشهد، مشهد، ایران.

2 دکترای تخصصی کنترل دارو، گروه علوم دارویی در طب ایرانی، دانشکده طب ایرانی و مکمل، دانشگاه علوم پزشکی مشهد، مشهد، ایران.

3 استادیار گروه آماری اپیدمیولوژی، مرکز تحقیقات مدیریت و تعیین کننده‌های اجتماعی سلامت، دانشکده بهداشت، دانشگاه علوم پزشکی مشهد، مشهد، ایران.

4 استادیار گروه بهداشت باروری، مرکز تحقیقات مراقبت‌های پرستاری و مامایی، دانشگاه علوم پزشکی مشهد، مشهد، ایران. دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی مشهد، مشهد، ایران.

چکیده

مقدمه: با توجه به ارتباط افسردگی و اختلال عملکرد جنسی و اثرات منفی آن بر کیفیت زندگی، مطالعه حاضر با هدف بررسی ژل واژینال افسنطین بر افسردگی زنان سنین باروری دارای اختلال عملکرد جنسی انجام شد.
روش‌کار: این مطالعه کارآزمایی بالینی تصادفی، دو گروهه و سه‌سو‌کور در سال 1400 بر روی 76 زن مراجعه‌کننده به درمانگاه زنان بیمارستان قائم (عج) مشهد انجام شد. ابزار این مطالعه شامل: پرسشنامه اطلاعات دموگرافیک، پرسشنامه شاخص عملکرد جنسی زنان (FSFI) و پرسشنامه افسردگی DASS-21 بود. در ابتدا افراد به‌طور تصادفی در دو گروه مداخله و دارونما قرار گرفتند و به‌مدت 4 هفته از ژل واژینال استفاده کردند. پرسشنامه عملکرد جنسی و افسردگی DASS-21 قبل و 4 هفته بعد از مداخله در دو گروه ارزیابی شد. تجزیه و تحلیل داده‌ها با استفاده از نرم‌افزار SPSS (نسخه 25) و آزمون‌های تی مستقل، من‌ویتنی، تی زوجی، ویلکاکسون و کای دو انجام شد. میزان p کمتر از 05/0 معنی‌دار در نظر گرفته شد.
یافته‌ها: قبل از مداخله بین میانگین نمره کل عملکرد جنسی (562/0=p) و افسردگی (140/0=p) در دو گروه تفاوت آماری معناداری وجود نداشت. بعد از 4 هفته مداخله، میانگین نمره عملکرد جنسی در گروه مداخله نسبت به گروه دارونما افزایش آماری معناداری داشت و میانگین نمره افسردگی در گروه مداخله نسبت به گروه دارونما به‌طور معناداری کاهش یافت (001/0>p) و زنانی که قبل مداخله، افسردگی متوسط یا خفیف داشتند، بعد از مداخله افسردگی خفیف داشتند یا افسردگی نداشتند.
نتیجه‌گیری: ژل افسنطین به‌طور مؤثری می‌تواند در زنانی که افسردگی متوسط یا خفیف دارند و دارای اختلال عملکرد جنسی هستند، سبب بهبود افسردگی گردد.

کلیدواژه‌ها

عنوان مقاله [English]

The effect of wormwood vaginal gel on depression in women of reproductive age with sexual dysfunction: A randomized controlled clinical trial

نویسندگان [English]

  • Niloufar Hajatpour 1
  • Roshanak Salari 2
  • Jamshid Jamali 3
  • Rahele Babazadeh 4
1 M.Sc. student of Midwifery, Student Research Committee, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran.
2 PhD in Drug Control, Department of Pharmaceutical Sciences in Iranian Medicine, School of Pharmaceutical Sciences in Iranian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
3 Assistant Professor, Department of Statistical Epidemiology, Center for Research on Management and Social Determinants of Health, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran.
4 Assistant Professor, Department of Reproductive Health, Nursing and Midwifery Care Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran.
چکیده [English]

Introduction: Regarding to the relationship between depression and sexual dysfunction and its negative effects on quality of life, this study was performed aimed to investigate the effect of wormwood vaginal gel on depression in women of reproductive age with sexual dysfunction.
Methods: This two-group, triple- blinds randomized clinical trial study was performed in 2021 on 76 women referred to the gynecological clinic of Ghaem Hospital in Mashhad. The study tools included: Demographic Information, Female Sexual function Index (FSFI), and the DASS-21 Depression questionnaires. At first, the subjects were randomly divided into the intervention and placebo groups and used vaginal gel for 4 weeks. Sexual Function and DASS-21 questionnaires were assessed in two groups before and 4 weeks after the intervention. Data were analyzed by SPSS software) version 25) and Independent t, Mann-Whitney, Paired t, Wilcoxon and chi-square tests.  P< 0.05 was considered statistically significant.
Results: Before the intervention, there was no statistically significant difference between the mean score of total sexual function (P=0.562) and depression (P=0.140) in the intervention and placebo groups. Four weeks after the intervention, the mean score of sexual function significantly increased in the intervention group compared to the placebo group and the mean score of depression significantly decreased in the intervention group compared to the placebo group (P<0.001). The women with moderate or mild depression before the intervention had mild or no depression after the intervention.
Conclusion: Wormwood gel effectively improves depression in women with mild to moderate depression and sexual dysfunction.

کلیدواژه‌ها [English]

  • Depression
  • Sexual dysfunction
  • Wormwood

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مجله زنان، مامایی و نازایی ایران
دوره 25، شماره 6
شهریور 1401
صفحه 88-97

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