مکانیسم‌های مولکولی و ژن‌های درگیر در ناباروری مردان مبتلا به واریکوسل: مرور سیستماتیک

نوع مقاله : مروری

نویسندگان

1 دانشجوی دکتری ژنتیک مولکولی، پژوهشکده زیست فناوری صنعت و محیط زیست، پژوهشگاه ملی مهندسی ژنتیک و زیست فناوری، تهران، ایران.

2 دانشیار ژنتیک مولکولی، گروه زیستشناسی، پردیس علوم، دانشگاه یزد، یزد، ایران.

چکیده

مقدمه: یکی از شایع‌ترین دلایل ناباروری مردان، ناهنجاری واریوکسل است. مردان با سابقه خانوادگی واریکوسل بیشتر در معرض خطر ابتلاء به این ناهنجاری­­ها هستند. در نتیجه عوامل ژنتیکی و مولکولی ممکن است در بیماری‌زایی واریکوسل، مرتبط با ناباروری نقش مهمی ایفا ­کنند. لذا مطالعه مروری حاضر با هدف بررسی ژن­های کاندید و مکانیسم‌های مولکولی آنها و نقش ژنتیک در ابتلاء یا تشدید آن در واریکوسل انجام شد.
روش‌کار: در این مطالعه جهت یافتن مقالات مرتبط، پایگاه‌های اطلاعاتی لاتین (PubMed، Google Scholar) و فارسی (SID و Magiran) بدون محدودیت زمانی و با استفاده از کلمات کلیدی Varicocele،Male Infertility و Gene در بازه زمانی 4 ساله مورد جستجو قرار گرفتند.
یافته­ها: جهش یا پلی­مورفیسم­های ژن­های کاندید احتمالی از جمله NOS3، hoGG1، TNP1,2، GST، POLG، P53، MTHFR ACP1 اثرات متفاوتی بر اسپرم، اسپرماتوژنز و در کل واریکوسل دارند.
نتیجه‌گیری: تاکنون چندین ژن به‌عنوان کاندیدهای احتمالی برای وقوع و پیشرفت واریکوسل در جمعیت­های گوناگون جهان مورد بررسی قرار گرفته است که هرکدام اثرات متنوعی بر پاتوفیزیولوژی واریکوسل نشان داده است. بنابراین صحیح یا غلط بودن فرضیه (تأثیر ژنتیک بر واریکوسل) به‌دلیل نداشتن هماهنگی شواهد و اختلاف نظر هنوز مشخص نیست.

کلیدواژه‌ها

عنوان مقاله [English]

Molecular Mechanisms and Genes involved in Infertile Men with Varicocele: A Systematic Review

نویسندگان [English]

  • Seyede Nafiseh Tabatabaei 1
  • Mohammad Mehdi Heidari 2
1 PHD Student in Molecular Genetics, Institute of Industrial and Environmental Biotechnology (IIEB), National Institute for Genetic and Biotechnology (NIGEB), Tehran, Iran.
2 Associate Professor of Molecular Genetics, Department of Biology, School of Sciences, Yazd University, Yazd, Iran.
چکیده [English]

Introduction: One of the most common causes of male infertility is Varicocele abnormality. Men with a family history of varicocele are at higher risk for these disorders. As a result, genetic and molecular factors may play an important role in the pathogenesis of varicocele associated with infertility. Therefore, this review study was performed with aim to investigate the role of candidate genes and their molecular mechanisms and the role of genetics in the development or exacerbation of varicocele.
Methods: In this review article, to find the related studies, the Latin (PubMed, Google Scholar) and Persian (SID and Magiran) databases were searched without time limitation in a period of 4 years using the keywords of "Varicocele, Male Infertility and Gene".
Results: Mutations or polymorphisms of probable candidate genes including GST, TNP1,2, hoGG1, NOS3, MTHFR ACP1, P53 and POLG have different effects on sperm, spermatogenesis and varicocele in general.
Conclusion: So far, several genes have been investigated as possible candidates for the occurrence and progression of varicocele in different populations of the world, each of which has shown various effects on the pathophysiology of varicocele. Therefore, the correctness or wrongness of the hypothesis (the effect of genetics on varicocele) is still unclear due to the lack of coordination of evidence.
 
Keywords: 

کلیدواژه‌ها [English]

  • Gene
  • Male Infertility
  • Single Nucleotid Polymorphism
  • Varicocele

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مجله زنان، مامایی و نازایی ایران
دوره 25، شماره 3
خرداد 1401
صفحه 96-112

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