بررسی مقایسه‌ای تأثیر کپسول "زنجبیل- اسطوخودوس" با "مفنامیک اسید" بر شدت دیسمنوره اولیه: یک کارآزمایی بالینی تصادفی شده

نوع مقاله : اصیل پژوهشی

نویسندگان

1 دانشجوی کارشناسی ارشد مامایی، کمیته تحقیقات دانشجویی، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران.

2 مربی گروه مامایی و بهداشت باروری، مرکز تحقیقات مامایی و بهداشت باروری، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران.

3 استادیار گروه آمار زیستی، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران.

4 استادیار گروه داروسازی سنتی، دانشکده طب سنتی، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران

چکیده

مقدمه: دیسمنوره یک مشکل اساسی در سلامت عمومی و فردی زنان می‌باشد. عوارض ناشی از مصرف داروهای ضدالتهاب غیراستروئیدی در این بیماری موجب شده است که تمایل به درمان‌های تکمیلی، جایگزین و گیاهان دارویی افزایش یابد. مطالعه حاضر با هدف بررسی مقایسه‌ای تأثیر کپسول زنجبیل- اسطوخودوس با مفنامیک اسید بر شدت دیسمنوره اولیه انجام شد.
روش‌کار: این مطالعه کارآزمایی بالینی سه‌سوکور در سال 1399 بر روی 60 دانشجوی ساکن خوابگاه‌های منتخب دانشگاه علوم پزشکی شهید بهشتی با سابقه دیسمنوره اولیه صورت گرفت. ابزار پژوهش پرسشنامه وضعیت قاعدگی، فرم اطلاعاتی مشخصات دموگرافیک و آنتروپومتریک و خط‌کش درد بود. در گروه مداخله کپسول‌های زنجبیل- اسطوخودوس و در گروه کنترل کپسول مفنامیک اسید 4 بار در روز به‌مدت 3 روز از شروع خونریزی قاعدگی تجویز و شدت درد در 2 ماه اندازه‌گیری شد. تجزیه و تحلیل داده‌ها با استفاده از نرم‌افزار SPSS (نسخه 24) و آزمون‌های تی مستقل، بونفرونی، فیشر و آنالیز واریانس انجام شد. میزان p‌ کمتر از 05/0 معنی‌دار در نظر گرفته شد.
یافته‌ها: قبل از مداخله از نظر شدت درد بین دو گروه اختلاف معناداری وجود نداشت (22/0=p). در مقایسه بین گروهی در سه سیکل با استفاده از آزمون آنالیز واریانس دو عاملی از نظر شدت درد در دو گروه "زنجبیل-اسطوخودوس" و"مفنامیک اسید" تفاوت آماری معناداری نشان داده شد (01/0=p). متوسط نمره درد نیز در گروه کپسول "زنجبیل- اسطوخودوس" 53/1 از کپسول "مفنامیک اسید" کمتر بود. از نظر طول مدت و شدت خونریزی به‌ترتیب در مقایسه سه سیکل در گروه "زنجبیل- اسطوخودوس" تفاوت معنا‌دار مشاهده شد (04/0=p، 03/0=p).
نتیجه‌گیری: کپسول زنجبیل- اسطوخودوس بدون داشتن عوارض جانبی، موجب کاهش درد دیسمنوره اولیه می‌شود و در مقایسه با مفنامیک اسید مؤثرتر است. می‌توان از کپسول زنجبیل- اسطوخودوس به‌عنوان داروی گیاهی مؤثر و بدون عارضه جانبی در کاهش درد دیسمنوره استفاده نمود.

کلیدواژه‌ها

عنوان مقاله [English]

Comparative study of the effect of "Ginger-Lavender" capsule with "Mefenamic Acid" on the severity of primary dysmenorrhea: A randomized clinical trial

نویسندگان [English]

  • Shadi Ahmadi 1
  • Sharareh Jannesari 2
  • Maliheh Nasiri 3
  • Shamim Sahranavard 4
1 M.Sc. Student in Midwifery, Student Research Committee, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2 Instructor, Department of Midwifery and Reproductive Health, Midwifery and Reproductive Health Research Center, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
3 Assistant professor, Department of Biostatistics, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
4 Assistant professor, Department of Traditional Pharmacy, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
چکیده [English]

Introduction: Dysmenorrhea‌ is a‌ major problem‌ in women's‌ general and ‌individual health. Complications of nonsteroidal anti-inflammatory drugs (NSAIDs) in this disease have led to an increase in the tendency to complementary, alternative and herbal remedies. ‌This study was performed with aim to compare the effect of‌ "Ginger-Lavender"‌ capsule with" Mefenamic Acid"‌ on the severity of primary dysmenorrhea.
 Methods: This triple-blind clinical trial study was conducted in in 2020 on 60 students with a history of primary dysmenorrhea living in the selected dormitories of Shahid Beheshti University of Medical Sciences. The research tools were the questionnaire of menstrual status, demographic and anthropometric characteristics form and pain line. In the intervention group, Ginger-Lavender capsules and in the control group, Mefenamic Acid capsules were prescribed four times daily for 3 days from the onset of menstruation bleeding. Pain intensity was measured during 2 months. Data were analyzed by SPSS software (version 24) and independent t-test,‌ Bonferroni, Fisher, and Analysis of Variance. P<0.05 was considered statistically significant.
Results: Before the intervention, there was no significant difference between the groups in terms of pain intensity ‌(p‌=‌0.22). Intergroup comparison in three cycles using two-factor analysis of variance showed a statistically significant difference between the two groups of ginger-lavender and mefenamic acid in terms of pain intensity (p = 0.01). The mean pain score in the ginger-lavender capsule group was 1.53 less than the mefenamic acid capsule group. There was a significant difference in the ginger-lavender group in the duration and severity of bleeding compared to the three cycles (p = 0.04 and P = 0.03), respectively).
Conclusion: The Ginger-Lavender‌ capsule without any side effects reduces the pain of primary dysmenorrhea and is more effective than Mefenamic Acid. Ginger-lavender capsule can be used as an effective herbal medicine without side effects in reducing dysmenorrhea pain.

کلیدواژه‌ها [English]

  • Dysmenorrhea
  • Ginger
  • Lavender
  • Mefenamic Acid

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مجله زنان، مامایی و نازایی ایران
دوره 24، شماره 12
بهمن 1400
صفحه 56-66

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