ﻣﻘﺎﻳﺴﻪ تأثیر دوش واژینال محلول آلوم (زاج سفید) با کرم واژینال ﻛﻠﻮﺗﺮﻳﻤﺎزول ﺑﺮ درمان ولوواژینیت کاندیدایی در زنان سنین باروری: یک کارآزمایی بالینی تصادفی شده

نوع مقاله : اصیل پژوهشی

نویسندگان

1 کارشناس ارشد مامایی، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی جندی شاپور اهواز، اهواز، ایران.

2 دانشیار گروه مامایی و بهداشت باروری، مرکز تحقیقات ارتقاء سلامت باروری، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی جندی شاپور اهواز، اهواز، ایران.

3 مربی گروه مامایی، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی جندی شاپور اهواز، اهواز، ایران.

4 استادیار گروه آمار زیستی و اپیدمیولوژی، دانشکده بهداشت، دانشگاه علوم پزشکی جندی شاپور اهواز، اهواز، ایران.

5 دانشیار گروه زنان و مامایی، مرکز تحقیقات باروری و ناباروری و سلامت جنین، دانشکده پزشکی، دانشگاه علوم پزشکی جندی شاپور اهواز، اهواز، ایران.

چکیده

مقدمه: با توجه به افزایش شیوع عفونت‌های کاندیدیازیس و از طرفی افزایش مقاومت دارویی به داروهای ضدقارچی رایج، لزوم یافتن ترکیبات طبیعی ضدکاندیدیایی ضروری است، لذا مطالعه حاضر با هدف ﻣﻘﺎﻳﺴﻪ تأثیر محلول واژینال آلوم (زاج سفید) با کرم ﻛﻠﻮﺗﺮﻳﻤﺎزول ﺑﺮ درمان ولوواژینیت کاندیدایی در زنان سنین باروری انجام شد.
روش‌کار: این مطالعه کارآزمایی بالینی تصادفی شده در سال 1399 بر روی 72 زن مراجعه کننده به مرکز بهداشتی درمانی شماره یک شرق اهواز با شکایت علائم بالینی ناشی از واژینیت کاندیدایی انجام شد. ابزار مورد استفاده، پرسشنامه اطلاعات دموگرافیک و مامایی و چک‌لیست مشاهدات و معاینات بود. افراد به‌صورت تصادفی بلوکی در دو گروه دریافت کننده کرم واژینال کلوتریمازول 1% و محلول زاج سفید (دوز 4 گرم در ۳۰ میلی‌لیتر) به‌مدت 7 روز قرار گرفتند. داده­ها قبل از شروع درمان و پس از تکمیل دوره درمان گردآوری و با استفاده از نرم‌افزار آماریSPSS (نسخه 21) و آزمون­های کای دو و تست دقیق فیشر مورد تجزیه و تحلیل قرار گرفتند. میزان p کمتر از 05/0 معنادار در نظر گرفته شد.
یافته‌ها: قبل از مداخله دو گروه مورد مطالعه از نظر علائم ناشی از واژینیت کاندیدیایی تفاوت آماری معنی‌داری نداشتند (05/0p>). بعد از مداخله، بین دو گروه از نظر خارش ولو و واژن و ترشح واژینال تفاوت آماری معناداری مشاهده شد؛ به‌طوری‌که در گروه محلول آلوم، میزان خارش و ترشح واژینال به‌طور معناداری کمتر از گروه کرم واژینال کلوتریمازول بود (05/0p<). با این وجود، دو گروه از نظر بهبودی سایر علائم یکسان بود و اختلاف آماری معناداری نداشتند (05/0p>).
نتیجه‌گیری: محلول واژینال زاج سفید و کرم واژینال کلوتریمازول به‌طور یکسان باعث بهبود واژینیت کاندیدایی در زنان سنین باروری شدند. با این وجود قبل از کاربرد این محلول به‌عنوان یک درمان جایگزین، انجام مطالعات بیشتر برای اثبات اثربخشی و ایمنی آن پیشنهاد می­گردد.

کلیدواژه‌ها

عنوان مقاله [English]

The effect of vaginal alum (white alum) solution and clotrimazole cream on the treatment of candidasis vulvovaginitis in women of childbearing age: A randomized clinical trial

نویسندگان [English]

  • Sorour Soltani 1
  • Mina Irvani 2
  • Parvaneh Mousavi 3
  • Saeed Ghanbari 4
  • Mahin Najafian 5
1 M.Sc. of Midwifery, School of Nursing and Midwifery, Ahvaz Jundishapur University of Medical sciences, Ahvaz, Iran.
2 Associate Professor, Department of Midwifery and Reproductive Health, Reproductive Health Promotion Research Center, School of Nursing and Midwifery, Ahvaz Jundishapur University of Medical sciences, Ahvaz, Iran.
3 Instructor, Department of Midwifery, School of Nursing and Midwifery, Ahvaz Jundishapur University of Medical sciences, Ahvaz, Iran.
4 Assistant Professor, Department of Biostatistics and Epidemiology, School of Health, Ahvaz Jundishapur University of Medical sciences, Ahvaz, Iran.
5 Associate Professor, Department of Obstetrics and Gynecology, Fertility, Infertility and Fetal Health Research Center, Faculty of Medicine, Ahvaz Jundishapur University of Medical sciences, Ahvaz, Iran.
چکیده [English]

Introduction: Due to the increasing prevalence of candidiasis infections and the increase in drug resistance to common antifungal drugs, it is necessary to find natural anti-candidiasis compounds. Therefore, this study was performed with aim to compare the effect of vaginal solution of alum (alum) with clotrimazole cream in the treatment of vaginal candidiasis in women of childbearing age.
Methods: This randomized clinical trial study was performed in 2020 on 72 women referred to East Ahvaz Health Center No. 1 with complaint of clinical signs of candida vaginitis. The tools were a demographic and midwifery information questionnaire and a checklist of observations and examinations. The subjects were randomly divided into two groups receiving clotrimazole 1% vaginal cream and white alum solution for 7 days. Data were collected before and after treatment and were analyzed by SPSS software (version 21) and Chi-square and Fisher's exact tests. P<0.05 was considered statistically significant.
Results: Before the intervention, the two groups did not have any statistically significant differences in the symptoms of candida vaginitis (P > 0.05). After the intervention, there was a statistically significant difference between the two groups in terms of vulvar and vaginal itching and vaginal discharge, so that in the alum solution group, the amount of itching and vaginal discharge was significantly less than the clotrimazole vaginal cream group (p < 0.05). However, the two groups were the same in terms of improvement of other symptoms and did not show a statistically significant difference (P > 0.05).
Conclusion: The alum vaginal solution and clotrimazole vaginal cream similarly improved candidiasis vaginitis in women of childbearing age. However, before using this solution as an alternative treatment, further studies are recommended to prove its effectiveness and safety.

کلیدواژه‌ها [English]

  • Alum (white alum)
  • Clotrimazole
  • Vaginal candidiasis
  • Vaginal infection

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مجله زنان، مامایی و نازایی ایران
دوره 24، شماره 12
بهمن 1400
صفحه 43-55

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