بررسی مقایسه ای سطح سرمی سرب در مادران باردار با زایمان ترم و پره ترم

نوع مقاله : اصیل پژوهشی

نویسندگان

1 استاد گروه زنان و مامایی، واحد توسعه تحقیقات بالینی بیمارستان امام رضا (ع)، دانشکده پزشکی، دانشگاه علوم پزشکی کرمانشاه، کرمانشاه، ایران.

2 استادیار گروه بهداشت باروری، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی کرمانشاه، کرمانشاه، ایران.

3 دستیار تخصصی زنان و مامایی، واحد توسعه تحقیقات بالینی بیمارستان امام رضا (ع)، دانشکده پزشکی، دانشگاه علوم پزشکی کرمانشاه، کرمانشاه، ایران.

4 کارشناس ارشد آمار، واحد توسعه تحقیقات بالینی بیمارستان امام رضا (ع)، دانشگاه علوم پزشکی کرمانشاه، کرمانشاه، ایران.

5 کارشناس ارشد مشاوره در مامایی، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی کرمانشاه، کرمانشاه، ایران.

6 استاد گروه آمار زیستی، دانشکده بهداشت، دانشگاه علوم پزشکی کرمانشاه، کرمانشاه، ایران.

چکیده

مقدمه: آلودگی محیط زیست و قرار گرفتن افراد در معرض فلزات سنگین از جمله سرب، می­تواند منجر به عوارض نامطلوب بارداری نظیر زایمان پره­ترم گردد. با توجه به این که یافته­ها و شواهد در این خصوص هنوز متناقض هستند، مطالعه حاضر با هدف تعیین مقایسه سطح سرمی سرب در مادران باردار با زایمان ترم و پره­ترم انجام گرفت.
روش‌کار: این مطالعه مورد- شاهدی در سال 98-1396 بر روی 108 نفر از زنان باردار مراجعه‌کننده به بیمارستان امام رضا (ع) کرمانشاه در دو گروه مورد (زایمان پره­ترم) و گروه شاهد (زایمان ترم) انجام شد. از هر مادر ترم و پره­ترم 2 سی‌سی نمونه خون در بیمارستان (محل بستری مادران) گرفته شد. پس از آماده شدن نتایج آزمایشگاهی سطح سرب خون مادران و تکمیل شدن پرسشنامه‌ها، تجزیه و تحلیل داده‌ها با استفاده از نرم‌ا‌فزار آماری SPSS (نسخه 24) و آزمون‌های آماری تی تست، کای اسکوئر و آزمون دقیق فیشر انجام گرفت. میزان p کمتر از 05/0 معنی‌دار در نظر گرفته شد.
یافته‌ها: میانگین سطح سرب در کل مادران 96/2±60/6 میکروگرم بر دسی‌لیتر بود که به‌ترتیب میانگین سطح سرب در گروه مادران با زایمان ترم 63/2±73/6 میکروگرم بر دسی‌لیتر و در گروه مادران با زایمان پره­ترم 55/3±34/6 میکروگرم بر دسی‌لیتر بود. از نظر سطوح سرب بین دو گروه زایمان ترم و پره­ترم اختلاف آماری معناداری مشاهده نشد (1/0=p). همچنین سطح سرمی سرب در دو گروه مادران ترم و پره­ترم بر اساس محل سکونت شهر (424/0=p) و روستا (354/0=p) اختلاف آماری معناداری نداشت.
نتیجه‌گیری: از نظر سطوح سرب بین دو گروه زایمان ترم و پره­ترم اختلاف آماری معناداری مشاهده نشد، اما به‌نظر می­رسد همچنان انجام پژوهش­های مشابه در مناطق مختلف کشور لازم است تا بتوان به اطلاعات کاملاً دقیق در مورد ارتباط سرب و زایمان پره­ترم و دیگر عوارض بارداری و زایمان دست یافت.

کلیدواژه‌ها

عنوان مقاله [English]

Serum levels of lead in pregnant women with term and preterm deliveries

نویسندگان [English]

  • Negin Rezavand 1
  • Mastaneh Kamravamanesh 2
  • Nooshin Abasi 3
  • Maryam Hemati 4
  • Rozhin Feali 5
  • Mansour Rezaei 6
1 Professor, Department of Obstetrics and Gynecology, Clinical Research Development Center of Imam Reza Hospital, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
2 Assistant Professor, Department of Reproductive Health, School of Nursing and Midwifery, Kermanshah University of Medical Sciences, Kermanshah, Iran.
3 Resident, Department of Obstetrics and Gynecology, Clinical Research Development Center of Imam Reza Hospital, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
4 M.Sc. of Statistics, Clinical Research Development Center of Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran.
5 M.Sc. of Midwifery Counseling, School of Nursing and Midwifery, Kermanshah University of Medical Sciences, Kermanshah, Iran.
6 Professor, Department of Biostatistics, School of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran
چکیده [English]

Introduction: Environmental pollution and exposure to heavy metals such as lead can lead to adverse pregnancy complications such as preterm delivery. Due to the fact that the findings and evidence in this regard are still contradictory, this study was performed with aim to compare serum levels of lead in pregnant women with term and preterm delivery.
Methods: This case-control study was performed in 2017-2019 on 108 pregnant women referred to Imam Reza Hospital affiliated to Kermanshah University of Medical Sciences in two groups of case (preterm delivery) and control group (term delivery). 2 cc of blood sample was taken from each term and preterm mothers in the hospital (where the mothers were hospitalized). After preparing the laboratory results of serum levels of lead and completing the questionnaires, data were analyzed by SPSS software (version 24) and T-test, Chi-square and Fisher's exact tests. P<0.05 was considered statistically significant.
Results: The mean level of lead in all mothers was 6.60 ± 2.96 μg / dl. The mean level of lead in the group of mothers with term delivery was 6.73±2.63 μg / dl and in the group of mothers with preterm delivery was 6.34±3.55 μg / dL. There was no statistically significant difference in lead levels between the two groups of term and preterm deliveries (P = 0.1). Also, there was no statistically significant difference in serum levels of lead between the two groups of term and preterm mothers based on place of residence of city (p=0.424) and village (p=0.3545).
Conclusion: There was no statistically significant difference in lead levels between the two groups of term and preterm deliveries, but it still seems that performing the similar research in different parts of the country is needed to provide accurate information about the relationship between lead and preterm delivery and other complications of pregnancy and childbirth.

کلیدواژه‌ها [English]

  • Preterm delivery
  • Serum lead level
  • Term delivery

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مجله زنان، مامایی و نازایی ایران
دوره 24، شماره 12
بهمن 1400
صفحه 8-15

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