بررسی ارتباط ویتامین D با سقط جنین: یک مرور سیستماتیک و متاآنالیز

نوع مقاله : مروری

نویسندگان

1 دانشجوی دکترای مامایی، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی تبریز، تبریز، ایران

2 استادیار گروه آموزش بهداشت و ارتقای سلامت، دانشکده بهداشت، دانشگاه علوم پزشکی تبریز، تبریز، ایران

3 استاد گروه بهداشت باروری، مرکز تعیین‌کننده‌های اجتماعی مؤثر بر سلامت، دانشگاه علوم پزشکی تبریز، تبریز، ایران.

چکیده

مقدمه: سقط خودبه‌خودی، یکی از عوارض شایع بارداری است که علل اصلی آن ناشناخته مانده است؛ از آنجایی که ممکن است کمبود ویتامین D یکی از علل آن باشد، مطالعه مرور سیستماتیک حاضر با هدف بررسی ارتباط ویتامین D با سقط جنین انجام شد.
روش‌کار: در این مرور سیستماتیک و متاآنالیز، جستجوی متون منتشر شده در بازه زمانی ابتدای سال 1990 تا انتهای سال 2019 در پایگاه داده­های Pubmed، Embase، Cochrane Library، Scopus، Web of Science، SID، Magiran، IranMedex با کلیدواژه­های ویتامین D، Pregnancy loss،  25-Dihydroxyvitamin d3،25-hydroxyvitamin ، Fetal loss، Miscarriage و Abortion  و کلیدواژه­های فارسی معادل آنها انجام شد. کیفیت مقالات با چک­لیست اوتاوا مورد ارزیابی قرار گرفت و از نرم­افزار STATA برای انجام متاآنالیز استفاده شد.
یافته­ها: از 311 مقاله یافت شده در مرحله اول، در نهایت 5 مقاله (5203 نفر) واجد معیارهای مطالعه بودند. از نظر کیفیت متدولوژی، تمامی مقالات وارد شده در سطح متوسط قرار داشتند. یافته­های مطالعات وارد شده به متاآنالیز نشان داد که بین سطوح پایین ویتامین D و سقط جنین ارتباط وجود دارد (اندازه اثر: 02/0، فاصله اطمینان 95%: 06/0 تا 02/0-).
نتیجه­گیری: نتایج متاآنالیز بیانگر ارتباط سطح سرمی ویتامین D با سقط جنین بود؛ بنابراین این‌گونه می­توان نتیجه گرفت که سطوح پایین ویتامین D به‌عنوان یک عامل خطر برای تهدید به سقط جنین محسوب می­شود.

کلیدواژه‌ها


عنوان مقاله [English]

The relationship between vitamin D and abortion: a systematic review and meta-analysis

نویسندگان [English]

  • Rana Dousti 1
  • Leila Jahangiry 2
  • Mojgan Mirghafourvand 3
1 PhD Student in Midwifery, School of Nursing and Midwifery, Tabriz University of Medical Sciences, Tabriz, Iran.
2 Assistant Professor, Department of Health Education and Promotion, School of Health, Tabriz University of Medical Sciences, Tabriz, Iran.
3 Professor, Department of Reproductive Health, Social Determinants of Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
چکیده [English]

Introduction: Spontaneous abortion is one of the common complications of pregnancy that its etiology is unknown. Since vitamin D deficiency may be one of its causes, this systematic review was performed with aim to evaluate the relationship between vitamin D and abortion.
Methods: In this systematic review and meta-analysis, the literature published from 1990 until the end of 2019 were searched in databases of PubMed, Embase, Cochrane Library, Scopus, Web of Science, SID, Magiran, IranMedex with the keywords of Vitamin D, 25-hydroxyvitamin, 25-Dihydroxyvitamin D3, Pregnancy loss, fetal loss, miscarriage and abortion and the equivalent Persian keywords. The quality of the papers was examined using Ottawa checklist, and STATA software was used for the meta-analysis.
Results: Among 311 papers found in the first stage, finally 5 papers (5203 individuals) met the study criteria. In terms of methodological quality, all of the included articles were of average level. The findings of the studies included in the meta-analysis showed that there is a relationship between low levels of vitamin D and abortion (Effect size: 0.02; 95% Confidence Interval: -0.02 to 0.06).
Conclusion: The results of the meta-analysis suggested a relationship between serum level of vitamin D and abortion; thus, it can be concluded that low levels of vitamin D are considered as a risk factor for abortion.

کلیدواژه‌ها [English]

  • Abortion
  • Vitamin D
  • pregnancy
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