تأثیر تمرینات هوازی و مصرف آب انار بر سطوح سرمی استروژن، پروژسترون و پروتئین P53 در زنان مبتلا به سرطان پستان

نوع مقاله : اصیل پژوهشی

نویسندگان

1 دانشیار گروه تربیت بدنی و علوم ورزشی، دانشکده ادبیات و علوم انسانی، دانشگاه قم، قم، ایران.

2 استادیار گروه تربیت بدنی و علوم ورزشی، دانشکده ادبیات و علوم انسانی، دانشگاه شهرکرد، شهرکرد، ایران.

3 کارشناسی ارشد گروه تربیت بدنی و علوم ورزشی، دانشکده ادبیات و علوم انسانی، دانشگاه قم، قم، ایران.

4 استادیار گروه تربیت بدنی و علوم ورزشی، دانشکده ادبیات و علوم انسانی، دانشگاه غیرانتفاعی طلوع مهر قم، قم، ایران.

چکیده

مقدمه: سرطان پستان، شایع‌ترین سرطان و علت اصلی مرگ‌ومیر ناشی از سرطان در میان زنان است. مطالعه حاضر با هدف مقایسه تأثیر 8 هفته تمرین هوازی و مصرف مکمل آب انار بر سطوح سرمی استروژن، پروژسترون و پروتئینP53در زنان مبتلا به سرطان پستان انجام شد.
روش‌کار: این مطالعه نیمه‌تجربی به‌صورت پیش‌آزمون و پس‌آزمون در سال 1398 بر روی 40 نفر از زنان مبتلا به سرطان پستان استان قم انجام شد. افراد به‌طور تصادفی به چهار گروه 10 نفره کنترل، آب انار، تمرین هوازی و تمرین هوازی و مصرف آب انار تقسیم شدند. گروه‌های تمرین هوازی و تمرین هوازی+مصرف آب انار به‌مدت 8 هفته و هر هفته 3 جلسه تمرینات را انجام دادند. همچنین گروه‌های مصرف آب انار روز جلسه تمرین و در حالت ناشتا 100 سی‌سی آب انار مصرف می‌کردند. جهت بررسی متغیرهای تحقیق 48 ساعت قبل و بعد از اجرای پروتکل از شرکت‌کنندگان 4 سی‌سی خون گرفته شد. تجزیه و تحلیل داده‌ها با استفاده از نرم‌افزار آماری SPSS (نسخه 20) و آزمون تی مستقل و تحلیل واریانس یک طرفه انجام شد. میزان p کمتر از 05/0 معنادار در نظر گرفته شد.
یافته‌ها: نتایج تحقیق نشان داد که 8 هفته تمرین هوازی باعث کاهش معنی‌دار در سطوح سرمی استروژن، پروژسترون (05/0>p) و افزایش معنی‌دار در سطوح پروتئین P53 (05/0>p) در زنان مبتلا به سرطان پستان گردید. بر اساس نتایج مطالعه، استروژن و پروژسترون در گروه‌های مصرف آب انار و تمرین هوازی کاهش داشت، اما این کاهش معنی‌دار نبود (05/0>p). همچنین نتایج نشان داد که مصرف آب انار به‌مدت 8 هفته باعث کاهش غیر معنی‌داری در سطوح استروژن و پروژسترون و افزایش معنی‌داری در سطوح P53 زنان مبتلا به سرطان پستان گردیده است (05/0>p).
نتیجه‌گیری: تمرین هوازی+ مصرف آب انار باعث کاهش عوامل خطرزای سرطان پستان و افزایش پروتئین مرتبط با مرگ سلولی p53 در زنان مبتلا به سرطان می‌گردد.

کلیدواژه‌ها


عنوان مقاله [English]

The effect of aerobic exercise and pomegranate juice consumption on serum levels of estrogen, progesterone and P53 protein in women with breast cancer

نویسندگان [English]

  • Mohsen Akbarpour 1
  • Fazlollah Fathollahi Shoorabeh 2
  • Marziyeh Yousefvand 3
  • Maryam Ghasemi 3
  • Abbas Mehranpour 4
1 Associate Professor, Department of Physical Education and Sport Sciences, School of Literature and Humanity Sciences, University of Qom, Qom, Iran
2 Assistant Professor, Department of Physical Education and Sports Sciences, School of Literature and Humanity Sciences, Shahrekord University, Shahrekord, Iran.
3 M.Sc. of Physical Education and Sport Sciences, School of Literature and Humanity Sciences, University of Qom, Qom, Iran.
4 Assistant Professor, Department of Physical Education and Sport Sciences, School of Literature and Humanity Sciences, Qom University of Toloe Mehr, Qom, Iran.
چکیده [English]

Introduction: Breast cancer is the most common cancer and the leading cause of death due to cancer among women. This study was performed with aim to compare the effect of 8 weeks of aerobic exercise and pomegranate juice supplementation on serum levels of estrogen, progesterone and P53 protein in women with breast cancer.
Methods: This quasi-experimental study was performed as pretest and posttest in 2019 on 40 women with breast cancer in Qom province. The subjects were randomly divided into four groups: control, pomegranate juice, aerobic exercise, and aerobic exercise + pomegranate juice consumption (n=10 in each group). The groups of aerobic exercise and aerobic exercise + pomegranate juice consumption performed aerobic exercise for 8 weeks and 3 sessions each week. Also, the groups of pomegranate juice consumption consumed 100 cc of pomegranate juice on the day of the training session fasting. 4 cc blood samples were taken from the participants 48 hours before and after the implementation of the protocol to evaluate the research variables. Data were analyzed by SPSS statistical software (version 20) and independent t-test and one-way analysis of variance. p < 0.05 was considered statistically significant.
Results: The results showed that 8 weeks of aerobic exercise significantly decreased serum levels of estrogen, progesterone (p <0.05) and significantly increased p53 protein levels (p <0.05) in women with breast cancer. According to the results of the study, estrogen and progesterone decreased in pomegranate juice consumption and aerobic exercise groups, but this decrease was not significant (p <0.05). The results also showed that consumption of pomegranate juice for eight weeks caused  no significant decrease in estrogen and progesterone levels and a significant increase in p53 levels in women with breast cancer (p <0.05).
Conclusion: Aerobic exercise + pomegranate juice consumption reduces the risk factors for breast cancer and increases the protein associated with p53 cell death in women with cancer.

کلیدواژه‌ها [English]

  • aerobic exercise
  • P53
  • Breast Cancer
  • Estrogen
  • Progesterone
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