بررسی اثر دارچین بر سندرم تخمدان پلیکیستیک: مرور سیستماتیک

نوع مقاله : مروری

نویسندگان

1 دکترای سلامت باروری، مرکز تحقیقات اندوکرینولوژی تولید مثل، پژوهشکده علوم غدد درون‌ریز و متابولیسم، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران.

2 استاد، مرکز تحقیقات اندوکرینولوژی تولید مثل، پژوهشکده علوم غدد درون‌ریز و متابولیسم، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران.

چکیده

مقدمه: تاکنون اثربخشی انواع گیاهان دارویی بر علائم بالینی و غیر بالینی سندرم تخمدان پلی­کیستیک مورد بررسی قرار گرفته است. مطالعه حاضر با هدف تعیین اثربخشی دارچین بر سندرم تخمدان پلی­کیستیک به‌صورت مرور سیستماتیک انجام شد.
روش‌کار: در این مطالعه مرور سیستماتیک جستجوی مطالعات در پایگاه‌های ایرانی و بین‌المللیPubMed ،Scopus ،web of science ،web of science ،Cochrane library ،Magiran ،SID ،IranDoc  در ماه فوریه 2020 انجام شد. جهت جستجو از واژه‌های سندرم تخمدان پلی­کیستیک، دارچین، گیاه دارویی و واژه‌های معادل انگلیسی استفاده شد. در این مطالعه، انواع مطالعات تجربی و نیمه‌تجربی انسانی و حیوانی که با هدف بررسی اثر دارچین بر جنبه‌های مختلف سندرم تخمدان پلی­کیستیک بود، وارد شدند.
یافته‌ها: در این مطالعه مرور سیستماتیک 588 مقاله مورد بررسی قرار گرفت که در نهایت 8 مقاله پژوهشی اصیل از نوع انسانی، 1 مقاله به‌صورت مقاله ارائه شده در کنگره و 3 مقاله از نوع حیوانی دارای معیارهای ورود به مطالعه بودند. در زمینه پیامد اولیه مورد بررسی، یک مطالعه بهبود معنادار در وضعیت تکرر سیکل قاعدگی (بهبود وضعیت الیگومنوره) را گزارش کرده بود، همچنین 6 مطالعه بهبود معناداری در شاخص‌های متابولیک و یک مطالعه کاهش سطح آنتی‌مولرین هورمون را گزارش کردند. در زمینه مطالعات حیوانی، بهبود شاخص‌های متابولیک، سطوح هورمونی و بلوغ فولیکول گزارش شده بود.
نتیجه‌گیری: نتایج اکثریت مطالعات انسانی و حیوانی حاکی از این بود که مصرف دارچین می‌تواند در بهبود شاخص‌های متابولیک و برخی علائم بالینی در بیماران مبتلا به سندرم تخمدان پلی­کیستیک مؤثر باشند، اما توصیه می‌شود مطالعات کارآزمایی بالینی گسترده در جهت تعیین اثربخشی و دوز آن در زنان مبتلا به سندرم تخمدان پلی­کیستیک انجام شود.

کلیدواژه‌ها

عنوان مقاله [English]

Effect of cinnamon on polycystic ovary syndrome (PCOS): A Systematic Review

نویسندگان [English]

  • Marzieh Saei Ghare Naz 1
  • Fahimeh Ramezani Tehrani 2
1 PhD of Reproductive Health, Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences and Metabolism, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2 Professor, Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences and Metabolism, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
چکیده [English]

Introduction: The effectiveness of various medicinal plants on clinical and non-clinical symptoms of PCOS has been investigated. This study was performed with aim to determine the efficacy of cinnamon on PCOS in a systematic review.
Methods: In this systematic review study, the studies were searched in the Iranian and international databases of PubMed, Scopus, Web of science, Cochrane library, Magiran, SID, and IranDoc in February 2020. The terms of "polycystic ovary syndrome", "cinnamon" and "medicinal plant" were used for the searching process. In this study, a variety of experimental and semi-experimental human and animal studies with aim to evaluate the effect of cinnamon on PCOS were entered to the study.
Results: In this systematic review study, 588 articles were reviewed, and finally, eight original human research articles, 1 article as an article presented in the congress, and 3 animal articles had the inclusion criteria. In terms of primary outcome, one study had reported a significant improvement in the frequency of menstrual cycles (improvement in oligomenorrhea status), six studies had reported a significant improvement in metabolic indicators, and one study had reported a decrease in Anti-mullerian hormone levels. Animal studies had reported improvement in metabolic indicators, hormonal levels, and follicle maturation.
Conclusion: The majority of human and animal studies indicated that cinnamon consumption can be useful in improving metabolic indicators and some clinical symptoms in patients with PCOS. Therefore, more clinical trial studies are recommended to be performed for determining its efficacy and dose.

کلیدواژه‌ها [English]

  • Cinnamon
  • Polycystic Ovary Syndrome
  • Systematic Review

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مجله زنان، مامایی و نازایی ایران
دوره 23، شماره 12
اسفند 1399
صفحه 86-97

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