تأثیر 5 ماه ورزش ایروبیک با شدت کم تا متوسط بر سطوح سرمی آنزیم‌های کبدی زنان مبتلا به کم‌کاری تیروئید تحت ‌بالینی

نوع مقاله : اصیل پژوهشی

نویسندگان

1 کارشناس ارشد فیزیولوژی ورزشی، دانشکده ادبیات و علوم انسانی، دانشگاه لرستان، خرمآباد، ایران.

2 استادیار گروه علوم ورزشی، دانشکده ادبیات و علوم انسانی، دانشگاه لرستان، خرم‌آباد، ایران.

چکیده

مقدمه: فعالیت ‌بدنی بر میزان غلظت آنزیم‌های کبدی تأثیر مطلوبی دارد. همچنین، مقادیر آنزیم‌های کبدی در افراد مبتلا به کم‌کاری تیروئید تحت‌بالینی بالاست. از این‌رو، مطالعه حاضر با هدف بررسی تأثیر 5 ماه ورزش ایروبیک با شدت کم تا متوسطبر سطوح سرمی آنزیم‌های کبدی ALT، AST و ALP در زنان مبتلا به کم‌کاری تیروئید تحت‌بالینی انجام شد.
روش‌کار: این مطالعه نیمه‌تجربی با طرح پیش‌‌آزمون و پس‌آزمون در سال 1395 بر روی 25 نفر از زنان مبتلا به کم‌کاری تیروئید تحت‌بالینی در شهرستان آبدانان انجام شد. افراد به سه گروه دارو- ورزش، ورزش و دارو تقسیم شدند. تمرین ورزشی هوازی شامل 5 ماه ورزش ایروبیک به‌صورت 3 جلسه در هفته و هر جلسه به­مدت 60 دقیقه بود. گروه دارو، افراد غیرفعالی بودند که تنها قرص لووتیروکسین مصرف ‌کردند. مقادیر ALT، AST و ALP سرمی سه گروه پس از 5 ماه اندازه‌گیری شد. تجزیه و تحلیل داده‌ها با استفاده از نرم‌افزار آماری SPSS (نسخه 24) و آزمون­های تی همبسته و آنالیز واریانس یک‌طرفه انجام شد.میزان p‌ کمتر از 05/0 معنی‌دار در نظر گرفته شد.
یافته‌ها: ورزش ایروبیک با شدت کم تا متوسطمنجر به تغییرات معنی‌داری در غلظت‌های سرمی ALT (054/0=p)، AST (065/0=p) و ALP (108/0=p) در زنان مبتلا به کم‌کاری تیروئید تحت‌بالینی نشد.
نتیجه‌گیری: بر اساس نتایج این مطالعه، 5 ماه ورزش ایروبیک با شدت کم تا متوسطمنجر به تغییرات معنی‌داری در غلظت آنزیم‌های کبدی ALT، AST و ALP زنان مبتلا به کم‌کاری تیروئید تحت‌بالینی نمی‌شود، بنابراین 5 ماه ورزش ایروبیک در بهبود NAFLD این افراد تأثیر ندارد.

کلیدواژه‌ها


عنوان مقاله [English]

Effect of 5 months aerobic exercise with low to moderate intensity on serum liver enzymes in subclinical hypothyroidism women

نویسندگان [English]

  • Mohammad Fathizadeh 1
  • Vahid Valipour Dehnou 2
  • Mohammad Fathi 2
1 M.Sc. in Exercise Physiology, School of Literature and Humanity Sciences, Lorestan University, Khoramabad, Iran.
2 Assistant Professor, Department of Sport Sciences, School of Literature and Humanity Sciences, Lorestan University, Khoramabad, Iran.
چکیده [English]

Introduction: Physical activity has a beneficial effect on liver enzymes concentration. Also, patients with subclinical hypothyroidism have high levels of liver enzymes. Therefore, this study was performed with aim to investigate the effect of 5 months aerobics exercise with low to moderate intensity on serum levels of liver enzymes in subclinical hypothyroidism women.
Methods: This semi-experimental study with pre-test and post-test design was performed on 25 subclinical hypothyroidism women in Abdanan city in 2016. The subjects were divided into three groups: drug-exercise, exercise, and drug. Aerobics exercise training consisted of 3 sessions (60 min) per week for 5 months. The drug group was inactive persons who took only LT4 tablets. Levels of ALT, AST and ALP were measured in three groups after 5 months. Data were analyzed using SPSS software (version 24) and correlated t-test and one-way ANOVA test. PResults: Aerobics exercise with low to moderate intensity resulted in non-significant changes in serum levels of ALT (p=0.054), AST (p=0.065) and ALP (p=0.108) in subclinical hypothyroidism women.
Conclusion:According to the findings of the present study, 5 months aerobics exercise with low to moderate intensity leads to non-significant changes in serum liver enzymes of ALT, AST, and ALP in subclinical hypothyroidism women. Thus, 5 months aerobics exercise does not affect the improvement of non-alcoholic fatty liver in subclinical hypothyroidism women.

کلیدواژه‌ها [English]

  • Aerobics
  • Aerobic exercise training
  • Hypothyroidism
  • Liver enzymes
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