بررسی اثر داروهای گیاهی و مکمل‌های غذایی بر ماستالژی: مروری سیستماتیک و متاآنالیز بر کارآزمایی‌های بالینی در ایران

نوع مقاله : مروری

نویسندگان

1 کارشناس ارشد مامایی، مرکز تحقیقات مراقبت‌های پرستاری و مامایی، دانشگاه علوم پزشکی مشهد، مشهد، ایران.

2 کارشناس ارشد مامایی، مرکز تحقیقات مراقبت‌های پرستاری و مامایی، دانشگاه علوم پزشکی مشهد، مشهد، ایران. دانشجوی دکتری تخصصی بهداشت باروری، کمیته تحقیقات دانشجویی، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی مشهد، مشهد، ایران

3 دکترای بهداشت باروری، دانشکده پرستاری و مامایی رازی، دانشگاه علوم پزشکی کرمان، کرمان، ایران.

چکیده

مقدمه: ماستالژی، یکی از شایع‌ترین علل مراجعه زنان به مراکز درمانی است که با توجه به اهمیت آن، تجویز صحیح دارو اهمیت دارد. با توجه به عوارض داروهای شیمیایی، تمایل بیماران به استفاده از طب مکمل افزایش یافته است. مطالعه مرور سیستماتیک و متاآنالیز حاضر با هدف ارزیابی و جمع‌بندی نتایج کارآزمایی­های بالینی انجام شده در مورد تأثیر داروهای گیاهی و مکمل‌های غذایی بر ماستالژی در ایران انجام شد.
روش‌کار: مطالعه حاضر به صورت مرور سیستماتیک و متاآنالیز اثر داروهای گیاهی و مکمل‌های غذایی بر ماستالژی است که جستجوی مقالات با استفاده از کلیدواژه‌های ماستالژی، طب مکمل، گیاهان دارویی و معادل انگلیسی آنها در مجلات فارسی و انگلیسی زبان نمایه شده در SID، Iranmedx، Scopus، Magiran، Irandoc، Pubmed و Google scholar در فاصله سال‌های 2019-2007 انجام شد. جهت ارزیابی کیفیت مقالات از مقیاس جداد استفاده شد. معیار ورود به مطالعه شامل: مطالعات کارآزمایی بالینی انجام شده در زمینه ماستالژی و معیار خروج، عدم دسترسی به متن کامل مقاله و وجود بیش از یک مداخله در هر گروه و نداشتن گروه کنترل بود.
یافته‌ها: در این مطالعه، 14 مقاله که دارای معیارهای ورود به مطالعه بودند، مورد بررسی قرار گرفتند که دارای ترکیبات آنتی‌اکسیدانی، فلاونوئیدی با خاصیت ضدالتهاب و ضددرد بوده و در تسکین ماستالژی تأثیر مطلوبی داشتند. اطلاعات به‌دست آمده، استفاده از ویتاگنوس و ویتامین E را جهت درمان ماستالژی مورد حمایت قرار می‌دهد. ضمن اینکه بذرکتان نیز نتایج مطلوبی را ارائه داد. نتایج متاآنالیز با سه مطالعه نشان داد که هیچ تفاوت معنی­داری بین گل مغربی و ویتامین E وجود ندارد (648/0=p).
نتیجه‌گیری: از بین تمام روش‌های ذکر شده، ویتاگنوس و ویتامین E دارای شواهد بیشتر برای استفاده در درمان ماستالژی می‌باشند. برای کاربردی شدن سایر روش‌ها، مطالعات بیشتر ضروری است.

کلیدواژه‌ها

عنوان مقاله [English]

The effect of Herbal Medicines and Supplements on Mastalgia: A systematic review and meta-analysis of clinical trials in Iran

نویسندگان [English]

  • Sedigheh Sheidaei 1
  • Morvarid Irani 2
  • Masoumeh Ghazanfarpour 3
1 M.Sc. in Midwifery, Nursing and Midwifery Care Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
2 M.Sc. in Midwifery, Nursing and Midwifery Care Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. PhD Candidate of Reproductive Health, Student Research Committee, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran
3 PhD in Reproductive Health, Razi School of Nursing and Midwifery, Kerman University of Medical Science, Kerman, Iran.
چکیده [English]

Introduction: Mastalgia is one of the most common causes of women referring to treatment centers that regarding its importance, proper administration of the drug is important. Due to the complications of chemical drugs, the patients' tendency to use complementary medicine has been increased. This systematic review and meta-analysis was conducted with aim to evaluate and summarize the results of clinical trials on the effects of herbal medicines and dietary supplements on mastalgia in Iran.
Methods: This systematic review and meta-analysis evaluated the effect of herbal medicines and supplements on Mastalgia by searching the articles using the keywords of mastalgia, complementary medicine, herbal medicine, their English in Persian and English journals indexed in SID, Iranmedx,  Irandoc, Magiran, Scopus,  Pubmed  and Google scholar from 2007 until 2019. The Jadad scale was used to evaluate the quality of the articles. The inclusion criteria were: the randomized controlled trials (RCTs) on mastalgia and exclusion criteria were: no access to the full text and the existence of more than one intervention in each group and lack of control group.
Results: In this study, 14 articles with inclusion criteria were evaluated which had antioxidant, flavonoid, anti-inflammatory and analgesic properties and had a good effect on mastalgia relief. The obtained data supports the use of Vitagnus and vitamin E for the treatment of mastalgia. In addition, cotton seed also provided good results. The results of the meta-analysis on three studies showed no significant difference between vitamin E and Evening Primrose (p = 0.648).
Conclusion: Among all the above mentioned methods, Vitagnus and Vitamin E have more evidence for use in the treatment of mastalgia. Further studies are needed to apply other methods.

کلیدواژه‌ها [English]

  • Breast pain
  • Complementary medicine
  • Iran
  • Mastalgia
  • Medicinal plants

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مجله زنان، مامایی و نازایی ایران
دوره 22، شماره 3
خرداد 1398
صفحه 87-98

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