اثر تمرینات هوازی همراه با مکمل یاری کلرلا بر مقاومت به انسولین و سطح سرمی گرلین زنان چاق

نوع مقاله : اصیل پژوهشی

نویسندگان

1 کارشناس ارشد گروه تربیت بدنی، واحد محلات، دانشگاه آزاد اسلامی، محلات، ایران.

2 دانشیار گروه تربیت بدنی، واحد محلات، دانشگاه آزاد اسلامی، محلات، ایران.

3 استادیار گروه تربیت بدنی، دانشکده ادبیات و علوم انسانی، دانشگاه قم، قم، ایران.

چکیده

مقدمه: چاقی و اضافه وزن با بسیاری از بیماری‌ها ارتباط دارند. اثرات تمرین منظم یا کلرلا نیز هر یک به‌طور مجزا بر کنترل بیماری‌ها تأیید شده است. مطالعه حاضر با هدف بررسی اثر تمرینات هوازی همراه با مکمل یاری کلرلا بر مقاومت به انسولین و سطح سرمی گرلین زنان چاق غیر‌فعال انجام شد.
روش‌کار: این مطالعه کارآزمایی بالینی تصادفی دوسوکور در سال 1396 بر روی 32 زن چاق در شهرستان محلات انجام شد. افراد به‌طور تصادفی و مساوی در چهار گروه تمرین، مکمل کلرلا، تمرین+ مکمل و کنترل قرار گرفتند. مداخلات به‌مدت هشت هفته انجام شد. مصرف کلرلا، روزانه چهار عدد به شکل قرص مکمل 300 میلی‌گرمی بود. برنامه تمرینی شامل دویدن روی نوارگردان با 65% ضربان قلب بیشینه به‌مدت 16 دقیقه در هفته اول بود که در هفته هشتم به 30 دقیقه با 80% ضربان قلب بیشینه رسید. دو روز قبل و بعد از پایان مداخلات، به منظور اندازه‌گیری گرلین، گلوکز، انسولین و مقاومت انسولین، از هر چهار گروه در وضعیت 12 ساعت ناشتایی نمونه خونی اخذ گردید. تجزیه و تحلیل داده‌ها با استفاده از نرم‌افزار آماری SPSS (نسخه 16) و آزمون تحلیل واریانس دوطرفه با اندازه‌گیری مکرر انجام شد. میزان p‌ کمتر از 05/0 معنی‌دار در نظر گرفته شد.
یافته‌ها: گلوکز، انسولین و مقاومت به انسولین تنها در دو گروه تمرین+کلرلا و تمرین در مقایسه با دو گروه دیگر به‌طور معناداری کاهش یافت (05/0>p)، اما بین دو گروه تفاوت معنی‌دار نبود. میزان و الگوی تغییرات گرلین سرم در چهار گروه تفاوت معناداری نداشت (05/0<p).
نتیجه‌گیری: تمرینات هوازی منجر به کاهش مقاومت به انسولین زنان چاق می‌شود، اما اثر معناداری بر سطح سرمی گرلین ندارد. از طرف دیگر مصرف مکمل کلرلا اثر معناداری را بر هیچ‌کدام از متغیرها نشان نداد و افزودن آن به تمرین هوازی نیز اثر تمرین را بیشتر نکرد.

کلیدواژه‌ها


عنوان مقاله [English]

Effect of aerobic training with Chlorella supplement on insulin resistance and serum ghrelin levels in obese women

نویسندگان [English]

  • Maryam Esmaieli 1
  • Bahram Abedi 2
  • Fazlollah Fathollahi Shoorabeh 3
1 M.Sc. of Physical Education, Islamic Azad University, Mahallat Branch, Mahallat, Iran.
2 Associate Professor, Department of Physical Education, Islamic Azad University, Mahallat Branch, Mahallat, Iran.
3 Assistant Professor, Department of Physical Education, Faculty of Literature and Human Sciences, Qom University, Qom, Iran.
چکیده [English]

Introduction: Obesity and overweight are associated with many diseases. The effects of regular exercises or Chlorella on disease control have been also confirmed individually. The purpose of this study was to investigate the effect of aerobic training with Chlorella supplement on insulin resistance and serum ghrelin level in obese sedentary women.
Materials and Methods: This randomized double-blind clinical trial was conducted on 32 obese women in Mahallat city, Iran, in 2017. The subjects were randomly assigned into four groups of exercise, supplementation with Chlorella, exercise plus supplementation, and control. Interventions were completed for 8 weeks. The daily intake of Chlorella was four 300 mg tablets (1 before breakfast, 2 before lunch, and 1 before dinner). The aerobic exercise program included running on a treadmill for 16 min with a maximum heart rate of 65% in the first week, which reached to 30 min and a maximum heart rate of 80% in the eighth week. Two days before and after the end of the interventions, blood samples were taken from all four groups in order to measure ghrelin, glucose, insulin, and insulin resistance. Data analysis was performed in SPSS software (version 16) using two-way and repeated measurements ANOVA. P-value less than 0.05 was considered significant.
Results: Glucose and insulin levels, as well as insulin resistance were significantly reduced in the exercise plus Chlorella and exercise groups, compared to those in the other two groups (P<0.05). However, the levels and pattern of ghrelin changes were not significantly different among the four groups (P>0.05).
Conclusion: Aerobic exercises lead to the reduction of insulin resistance in obese women, but no significant effect was observed on ghrelin. On the other hand, Chlorella supplementation did not show any significant effect on any of the variables. The use of Chlorella supplement along with aerobic exercise also exerted no effect.

کلیدواژه‌ها [English]

  • Insulin resistance
  • Aerobic exercise
  • Ghrelin
  • Chlorella
  • Obesity
  1. Bahrami K, Shahdadi A. The effect of aerobic exercise on serum leptin levels and body mass index in obese young girls. Qom Univ Med Sci J 2015; 9(6):27-36. (Persian).
  2. Withrow D, Alter DA. The economic burden of obesity worldwide: a systematic review of the direct costs of obes ity. Obes Rev 2011; 12(2):131-41.
  3. Rashidlamir A, Mirzendehdel Z, Ebrahimi Atri A. The effect of an eight-week period of aerobic exercise on plasma concentration of ghrelin and growth hormone in young women. J Shahid Sadoughi Univ Med Sci 2011; 19(5):667-75. (Persian).
  4. Kojima M, Hosoda H, Matsuo H, Kangawa K. Ghrelin: discovery of the natural endogenous ligand for the growth hormone secretagogue receptor. Trends Endocrinol Metab 2001; 12(3):118-22.
  5. Hakimi M, Sheikholeslami Vatani D, Ali-Mohammadi M. Effect of concurrent training with ingested of L-carnitine supplementaton on hormonal changes, lipid profile and body composition in obese men. J Urmia Univ Med Sci 2015; 26(3):185-3. (Persian).
  6. Mirzaei B, Irandoust K, Rahmani-Nia F, Mohebbi H, Hassan-Nia S. Unacylated ghrelin levels increase after aerobic exercise in obese women. Brazil J Biomot 2009; 3(1):11-20.
  7. Neary NM, Goldstone AP, Bloom SR. Appetite regulation: from the gut to the hypothalamus. Clin Endocrinol 2004; 60(2):153-60.
  8. Ravussin E, Tschöp M, Morales S, Bouchard C, Heiman ML. Plasma ghrelin concentration and energy balance: overfeeding and negative energy balance studies in twins. J Clin Endocrinol Metab 2001; 86(9):4547-51.
  9. Assarzade Noushabadi M, Abedi B. Effects of combination training on insulin resistance index and some inflammatory markers in inactive men. Horizon Med Sci 2012; 18(3):95-105. (Persian).
  10. Coskun O, Ocakci A, Bayraktaroglu T, Kanter M. Exercise training prevents and protects streptozotocin-induced oxidative stress and beta-cell damage in rat pancreas. Tohoku J Exp Med 2004; 203(3):145-54.
  11. Bagheri Nia M, Abedi B. Effect of eight weeks of Pilates training on orexin and insulin resistance levels in overweight children. Yafte 2018; 20(1):112-2. (Persian).
  12. Janczyk P, Langhammer M, Renne U, Guiard V, Souffrant WB. Effect of feed supplementation with Chlorella vulgaris powder on mice reproduction. Arch Zootechnica 2006; 9:122-34.
  13. Jong-Yuh C, Mei-Fen S. Potential hypoglycemic effects of Chlorella in streptozotocin-induced diabetic mice. Life Sci 2005; 77(9):980-90.
  14. Jeong H, Kwon HJ, Kim MK. Hypoglycemic effect of Chlorella vulgaris intake in type 2 diabetic Goto-Kakizaki and normal Wistar rats. Nutr Res Pract 2009; 3(1):23-30.
  15. Kim S, Kim J, Lim Y, Kim YJ, Kim JY, Kwon O. A dietary cholesterol challenge study to assess Chlorella supplementation in maintaining healthy lipid levels in adults: a double-blinded, randomized, placebo-controlled study. Nutr J 2016; 15(1):54.
  16. Rasineni K, Bellamkonda R, Singareddy SR, Desireddy S. Antihyperglycemic activity of Catharanthus roseus leaf powder in streptozotocin-induced diabetic rats. Pharmacognosy Res 2010; 2(3):195-201.
  17. Ghanbari-Niaki A. Ghrelin and glucoregulatory hormone responses to a single circuit resistance exercise in male college students. Clin Biochem 2006; 39(10):966-70.
  18. Kraemer RR, Durand RJ, Hollander DB, Tryniecki JL, Hebert EP, Castracane VD. Ghrelin and other glucoregulatory hormone responses to eccentric and concentric muscle contractions. Endocrine 2004; 24(1):93-8.
  19. King NA, Lluch A, Stubbs RJ, Blundell JE. High dose exercise does not increase hunger or energy intake in free living males. Eur J Clin Nutr 1997; 51(7):478-83.
  20. Kodama S, Mia S, Yamada N, Sone H. Exercise training for ameliorating cardiovascular risk factors-focusing on exercise intensity and amount. Int J Sport Health Sci 2006; 4:325-38.
  21. Henriksen EJ. Effects of acute exercise and exercise training on insulin resistance. J Appl Physiol 2002; 93(2):788-96.
  22. Kim HJ, Lee S, Kim TW, Kim HH, Jeon TY, Yoon YS, et al. Effects of exercise-induced weight loss on acylated and unacylated ghrelin in overweight children. Clin Endocrinl 2008; 68(3):416-22.
  23. Mizoguchi T, Arakawa Y, Kobayashi M, Fujishima M. Influence of Chlorella powder intake during swimming stress in mice. Biochem Biophys Res Commun 2011; 404(1):121-6.
  24. Nakhaei K, Ghofrani M, Fazel Bakhsheshi M, Nakhaei H. Effect of circuit resistance training and cinnamon supplement on body composition and Omentin-1 in overweight women. Iran J Obstet Gynecol Infertil 2018; 20(11):74-82. (Persian).
  25. Foster-Schubert KE, McTiernan A, Frayo RS, Schwartz RS, Rajan KB, Yasui Y. Human plasma ghrelin levels increase during a one-year exercise program. J Clin Endocrinol Metab 2005; 90(2):820-5.