مجله زنان، مامایی و نازایی ایران

مجله زنان، مامایی و نازایی ایران

ارتباط متغیرهای مرتبط با بارداری و خطر ابتلاء به سرطان پستان: مرور سیستماتیک

نویسندگان
زهره یگانه 1
زهره شیخان 2
نورالسادات کریمان 3
پرستو حاجیان 4
ملیحه نصیری 5
نرگس میرزاده 6
1 دانشجوی کارشناسی ارشد مامایی، کمیته تحقیقات دانشجویی، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران.
2 مربی گروه مامایی، مرکز تحقیقات مامایی و بهداشت باروری، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران.
3 استادیار گروه مامایی و بهداشت باروری، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران.
4 متخصص رادیوتراپی انکولوژی، بیمارستان شهدای تجریش، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران.
5 استادیار گروه آمار زیستی، دانشکده پیراپزشکی، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران.
6 دانشجوی کارشناسی ارشد مامایی، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران.
10.22038/ijogi.2018.10716
چکیده
مقدمه: سرطان پستان شایع‌ترین سرطان شناخته‌ شده در جهان است که سبب مرگ‌ومیر گسترده در زنان می‌گردد. در اکثر موارد عامل خطر شناخته شده‌ای برای مبتلایان به سرطان پستان شناسایی نشده است. به نظر می‌رسد تغییرات هورمونی وسیعی که در بارداری رخ می‌دهند، در بروز سرطان پستان نقش دارند. از آن‌جایی که شناسایی عوامل خطر این بیماری به پیشگیری اولیه و تشخیص زودرس سرطان پستان کمک می‌کند، مطالعه حاضر با هدف مروری سیستماتیک بر مطالعات انجام شده در مورد متغیرهای مرتبط با بارداری و خطر سرطان پستان در ایران و جهان انجام شد.
روش کار: در این مطالعه مرور سیستماتیک، مطالعات مورد نظر از پایگاه‌های اطلاعاتی Google Scholar، Scopus، Pubmed، Science Direct، Cochrane و SID با کلیدواژه‌های سرطان پستان و متغیرهای مرتبط بارداری در بازه زمانی 2000 تا 2017 جستجو شدند. بر اساس معیار نیوکاسل اتاوا، مطالعاتی که امتیاز 6 و یا بیشتر گرفتند، وارد مطالعه شدند. نتایج به صورت کیفی گزارش شد.
یافته ها: در این مطالعه 50 مقاله شامل 26 مقاله مورد شاهدی و 24 مقاله هم‌گروهی که دارای معیار ورود به مطالعه بودند، بررسی شدند. بررسی‌ها نشان داد در بین متغیرهای مورد بررسی، سقط و پره­اکلامپسی ارتباط قوی‌تری با سرطان پستان دارند.
نتیجه گیری: به نظر می‌رسد که وجود سابقه‌ سقط باعث افزایش خطر سرطان پستان می‌گردد. همچنین سابقه پره­اکلامپسی نقشی محافظت‌کننده در سرطان پستان دارد. در مورد ارتباط دیابت بارداری و چندقلویی با سرطان پستان، نیاز به انجام مطالعات بیشتر است.
کلیدواژه‌ها
پره­اکلامپسی
چندقلویی
دیابت بارداری
سرطان پستان
سقط
مرور سیستماتیک

عنوان مقاله English

Relationship between pregnancy-associated variables and breast cancer risk: A systematic review

نویسندگان English

Zohreh Yeganeh 1
Zohre Sheikhan 2
Nourossadat Kariman 3
Parasto Hajian 4
Malihe Nasiri 5
Narges Mirzadeh 6
1 M.Sc. Student of Midwifery, Student Research Committee, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2 Instructor, Department of Midwifery, Midwifery and Reproductive Health Research Center, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
3 Assistant Professor, Department of Midwifery and Reproductive Health, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
4 Radiotherapist-oncologist, Department of Radiotherapy and Oncology, Shohada Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
5 Assistant Professor, Department of Biostatics, Faculty of Paramedics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
6 M.Sc. Student of Midwifery, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
چکیده English

Introduction: Globally, breast cancer is the most common malignancy causing extensive mortality in women. In most cases, there is no known risk factor for breast cancer. Extensive hormonal changes that occur during pregnancy appear to be involved in the etiology of breast cancer. Since identifying risk factors helps with primary prevention and early diagnosis of breast cancer, this study was performed to systematically review studies about pregnancy-related variables and the risk of breast cancer in Iran and worldwide.
Methods: In this systematic review, we searched PubMed, Google Scholar, Scopus, SID, and Science Direct databases using keywords of “pregnancy-related variables” and “breast cancer” to retrieve articles published during 2000-2017. Then, those articles that obtained a score of ≥ 6 based on the Newcastle–Ottawa Scale were entered to the study. The results were reported qualitatively.
Results: Fifty articles consisting of 26 case-controls and 24 cohort articles, which met the inclusion criteria, were investigated. Our evaluations indicated that among the factors examined, abortion and preeclampsia had a stronger relationship with breast cancer.
Conclusion: History of abortion seems to increase the risk of breast cancer. Also, history of preeclampsia plays a protective role in breast cancer. Further studies are needed to examine the relationship of gestational diabetes and multiple gestations with breast cancer.

کلیدواژه‌ها English

Breast Cancer
Abortion
Preeclampsia
Gestational diabetes
Multiple gestations
Systematic review
  1. Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, et al. GLOBOCAN 2012: estimated cancer incidence, mortality and prevalence in 2012. International Agency for Research on Canser. Availabel at: URL: http://globocan.iarc.fr/Pages/fact_sheets_cancer.aspx; 2016.
  2. Breast cancer: prevention and control. World Health Organization. Available at: URL: http://www.who.int/cancer/detection/breastcancer/en; 2014.
    1. International agency for research on cancer. Latest world cancer statistics. World Health Organization. Available at: URL: http://www.iarc.fr/en/media-centre/pr/2013/pdfs/pr223_E.pdf 20; 2017.
  3. Mahdavifar N, Pakzad R, Ghoncheh M, Pakzad I, Moudi A, Salehiniya H. Spatial analysis of breast cancer incidence in Iran. Asian Pac J Cancer Prev 2016; 17(3):59-64.
  4. Jonatan S, Berek J. Novak's gynecology. 14th ed. Philadelphia: Lippincott Williams and Wilkins; 2012. P. 1204.
  5. Sperrof L, Fritz MA. Clinical gynecologic and infertility. 8th ed. Philadelphia: Lippincott Williams & Wilkins; 2011. P. 432.
  6. Breast cancer risk factors. Breast cancer: prevention and control. World Health Organization. Available at: URL: http://www.who.int/cancer/detection/breastcancer/en/index2.html; 2017.
  7. What are the risk factors for breast cancer? Centers for Disease Control and Prevention (CDC). Available at: URL: http://www.cdc.gov/cancer/breast/basic_info/risk_factors.htm; 2017.
  8. Abortion, miscarriage, and breast cancer risk. National Cancer Institute (NCI). Available at: URL: http://www.cancer.gov/types/breast/abortion-miscarriage-risk; 2017.
  9. Cunningham F, Leveno K, Bloom S, Spong CY, Dashe J. Williams obstetrics. 24th ed. New York: Mcgraw-Hill; 2014. P. 325, 488, 521, 734.
  10. Pregnancy complications. Centers for Disease Control and Prevention (CDC). Available at: URL: http://www.cdc.gov/reproductivehealth/maternalinfanthealth/pregcomplications.htm; 2017.
  11. Shachar Z, Lyell D. Interpregnancy interval and obstetrical complications. UpToDate. Available at: URL: http://www.uptodate.com/contents/search?search=pregnancy complications&sp=&searchType=PLAIN_TEXT&source; 2017.
  12. Wuu J, Hellerstein S, Lipworth L, Wide L, Xu B, Yu G, et al. Correlates of pregnancy oestrogen, progesterone and sex hormone-binding globulin in the USA and China. Eur J Cancer Prev 2002; 11(3):283-93.
  13. Troisi R, Potischman N, Roberts J, Ness R, Crombleholme W, Lykins D, et al. Maternal serum oestrogen and androgen concentrations in preeclamptic and uncomplicated pregnancies. Int J Epidemiol 2003, 32(3):455-60.
  14. Barnabei VM, Krantz DA, Macri JN, Larsen JW Jr. Enhanced twin pregnancy detection within an open neural tube defect and down syndrome screening protocol using free‐beta hCG and AFP. Prenat Diagn 1995; 15(12):1131-4.
  15. Hübinette A, Lichtenstein P, Brismar K, Vatten L, Jacobsen G, Ekbom A, et al. Serum insulin‐like growth factors in normal pregnancy and in pregnancies complicated by preeclampsia. Acta Obstet Gynecol Scand 2003; 82(11):1004-9.
  16. Muti P. The role of endogenous hormones in the etiology and prevention of breast cancer: the epidemiological evidence. Ann N Y Acad Sci 2004; 1028:273-82.
  17. Bernstein L. Epidemiology of endocrine-related risk factors for breast cancer. J Mammary Gland Biol Neoplasia 2002; 7(1):3-15.
  18. Forman MR, Cantwell MM, Ronckers C, Zhang Y. Through the looking glass at early-life exposures and breast cancer risk. Cancer Invest 2005; 23(7):609-24.
  19. Velie EM, Nechuta S, Osuch JR. Lifetime reproductive and anthropometric risk factors for breast cancer in postmenopausal women. Breast Dis 2006; 24(1):17-35.
  20. Troisi R, Potischman N, Hoover RN. Exploring the underlying hormonal mechanisms of prenatal risk factors for breast cancer: a review and commentary. Cancer Epidemiol Biomarkers Prev 2007; 16(9):1700-12.
  21. Nechuta S, Paneth N, Velie EM. Pregnancy characteristics and maternal breast cancer risk: a review of the epidemiologic literature. Cancer Causes Control 2010; 21(7):967-89.
  22. Moher D, Shamseer L, Clarke M, Ghersi D, Liberati A, Petticrew M, et al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst Rev 2015; 4(1):1.
  23. Wells GA, Shea B, O’connell D, Peterson J, Welch V, Losos M, et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. Ottawa (ON): Ottawa Hospital Research Institute; 2016.
  24. Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol 2010; 25(9):603-5.
  25. Cook DA, Reed DA. Appraising the quality of medical education research methods: the medical education research study quality instrument and the Newcastle–Ottawa scale-education. Acad Med 2015; 90(8):1067-76
  26. Sedgh G, Bearak J, Singh S, Bankole A, Popinchalk A, Ganatra B, et al. Abortion incidence between 1990 and 2014: global, regional, and subregional levels and trends. Lancet 2016; 388(10041):258-67.
  27. Russo J, Russo IH. Susceptibility of the mammary gland to carcinogenesis. II. Pregnancy interruption as a risk factor in tumor incidence. Am J Pathol 1980; 100(2):497-512.
  28. Russo J, Tay LK, Russo IH. Differentiation of the mammary gland and susceptibility to carcinogenesis. Breast Cancer Res Treat 1982; 2(1):5-73.
  29. Ahmed K, Asaduzzaman S, Bashar MI, Hossain G, Bhuiyan T. Association assessment among risk factors and breast cancer in a low income country: Bangladesh. Asian Pac J Cancer Prev 2015; 16(17):7507-12.
  30. Balekouzou A, Yin P, Pamatika CM, Bekolo CE, Nambei SW, Djeintote M, et al. Reproductive risk factors associated with breast cancer in women in Bangui: a case-control study. BMC Womens Health 2017; 17(1):14.
  31. Hosseinzadeh M, Eivazi Ziaei J, Mahdavi N, Aghajari P, Vahidi M, Fateh A, et al. Risk factors for breast cancer in Iranian women: a hospital-based case-control study in tabriz, Iran. J Breast Cancer 2014; 17(3):236-43.
  32. Toleutay U, Reznik V, Kalmatayeva Z, Smigelskas K. Risk factors of breast cancer in Kyzylorda oblast of Kazakhstan: a case-control study. Asian Pac J Cancer Prev 2013; 14(10):5961-4.
  33. Keihanian S, Ghaffari F, Fotokian Z, Shoormig R, Saravi M. Risk factors of breast cancer in Ramsar and Tonekabon. J Qazvin Univ Med Sci 2010; 14(2):9-12. (Persian).
  34. Hajian-Tilaki K, Kaveh-Ahangar T. Reproductive factors associated with breast cancer risk in northern Iran. Med Oncol 2011; 28(2):441-6.
  35. Jiang AR, Gao CM, Ding JH, Li SP, Liu YT, Cao HX, et al. Abortions and breast cancer risk in premenopausal and postmenopausal women in Jiangsu Province of China. Asian Pac J Cancer Prev 2012; 13(1):33-5.
  36. Qiu J, Yang R, Rao Y, Du Y, Kalembo FW. Risk factors for breast cancer and expression of insulin-like growth factor-2 (IGF-2) in women with breast cancer in Wuhan City, China. PLoS One 2012; 7(5):e36497.
  37. Sanderson M, Shu XO, Jin F, Dai Q, Wen W, Hua Y, et al. Abortion history and breast cancer risk: results from the Shanghai Breast Cancer Study. Int J Cancer 2001; 92(6):899-905.
  38. Holakouie Naeini K, Ardalan A, Mahmoudi M, Motevallian A, Yahyapour Y. Risk factors for breast cancer in Mazandaran Province, 2004. J Sch Public Health Inst Public Health Res 2006; 4(1):27-36. (Persian).
  39. Ozmen V, Ozcinar B, Karanlik H, Cabioglu N, Tukenmez M, Disci R, et al. Breast cancer risk factors in Turkish women--a University Hospital based nested case control study. World J Surg Oncol 2009; 7(1):37.
  40. Paoletti X, Clavel‐Chapelon F. Induced and spontaneous abortion and breast cancer risk: results from the E3N cohort study. Int J Cancer 2003; 106(2):270-6.
  41. Yanhua C, Geater A, You J, Li L, Shaoqiang Z, Chongsuvivatwong V, et al. Reproductive variables and risk of breast malignant and benign tumours in Yunnan province, China. Asian Pac J Cancer Prev 2012; 13(5):2179-84.
  42. Aminisani N, Shamshirgaran S, Ehdaivand F, Mardi A. Abortion and the risk of breast cancer among women in Mashhad. J Ardabil Univ Med Sci 2003; 3(1):7-12. (Persian).
  43. Mohamadi M, Kashfee F, Nikoofar A, Hoseini F. Risk factors of breast cancer. Iran J Nurs 2001; 13(26):23-30. (Persian).
  44. Braüner CM, Overvad K, Tjønneland A, Attermann J. Induced abortion and breast cancer among parous women: a Danish cohort study. Acta Obstet Gynecol Scand 2013; 92(6):700-5.
  45. Wu JQ, Li YY, Ren JC, Zhao R, Zhou Y, Gao ES. Induced abortion and breast cancer: results from a population-based case control study in China. Asian Pac J Cancer Prev 2014; 15(8):3635-40.
  46. Karim SM, Baeshen W, Neamatullah SN, Bin B. Oral contraceptives, abortion and breast cancer risk: a case control study in Saudi Arabia. Asian Pac J Cancer Prev 2015; 16(9):3957-60.
  47. Henderson KD, Sullivan-Halley J, Reynolds P, Horn-Ross PL, Clarke CA, Chang ET, et al. Incomplete pregnancy is not associated with breast cancer risk: the California Teachers Study. Contraception 2008; 77(6):391-6.
  48. Michels KB, Xue F, Colditz GA, Willett WC. Induced and spontaneous abortion and incidence of breast cancer among young women: a prospective cohort study. Arch Intern Med 2007; 167(8):814-20.
  49. Brewster DH, Stockton DL, Dobbie R, Bull D, Beral V. Risk of breast cancer after miscarriage or induced abortion: a Scottish record linkage case-control study. J Epidemiol Community Health 2005; 59(4):283-7.
  50. Tehranian N, Hafezipour F, Hajizade E. Survey of risk factors of breast cancer in women under 40 years. Daneshvar Med 2009; 16(81):37-44. (Persian).
  51. Pesaran Z, Rezaei A, Tavakoli Keh R, Siydat AH. Evaluation of breast cancer risk factors for using in hormone replacement therapy of corticosteroid- treated post-menopausal women. J Shahrekord Univ Med Sci 2003; 5(2):70-5. (Persian).
  52. Newcomb PA, Mandelson MT. A record-based evaluation of induced abortion and breast cancer risk (United States). Cancer Causes Control 2000; 11(9):777-81.
  53. Palmer JR, Wise LA, Adams-Campbell LL, Rosenberg L. A prospective study of induced abortion and breast cancer in African-American women. Cancer Causes Control 2004; 15(2):105-11.
  54. Abalos E, Cuesta C, Grosso AL, Chou D, Say L. Global and regional estimates of preeclampsia and eclampsia: a systematic review. Eur J Obstet Gynecol Reprod Biol 2013; 170(1):1-7.
  55. Kharaghani R, Cheraghi Z, Okhovat Esfahani B, Mohammadian Z, Nooreldinc RS. Prevalence of preeclampsia and eclampsia in Iran. Arch Iran Med 2016; 19(1):64-71.
  56. Tamimi R, Lagiou P, Vatten LJ, Mucci L, Trichopoulos D, Hellerstein S, et al. Pregnancy hormones, pre-eclampsia, and implications for breast cancer risk in the offspring. Cancer Epidemiol Biomarkers Prev 2003; 12(7):647-50.
  57. Innes KE, Byers TE. Preeclampsia and breast cancer risk. Epidemiology 1999; 10(6):722-32.
  58. Salamalekis E, Bakas P, Vitoratos N, Eleptheriadis M, Creatsas G. Androgen levels in the third trimester of pregnancy in patients with preeclampsia. Eur J Obstet Gynecol Reprod Biol 2006; 126(1):16-9.
  59. Wald NJ, Morris JK. Multiple marker second trimester serum screening for pre-eclampsia. J Med Screen 2001; 8(2):65-8.
  60. Pacheco NL, Andersen AM, Kamper-Jørgensen M. Preeclampsia and breast cancer: the influence of birth characteristics. Breast 2015; 24(5):613-7.
  61. Vatten LJ, Romundstad PR, Trichopoulos D, Skjaerven R. Pre-eclampsia in pregnancy and subsequent risk for breast cancer. Br J Cancer 2002; 87(9):971-3.
  62. Cohn BA, Cirillo PM, Christianson RE, van den Berg BJ, Siiteri PK. Placental characteristics and reduced risk of maternal breast cancer. J Natl Cancer Inst 2001; 93(15):1133-40.
  63. Opdahl S, Romundstad PR, Alsaker MD, Vatten LJ. Hypertensive diseases in pregnancy and breast cancer risk. Br J Cancer 2012; 107(1):176-82.
  64. Innes KE, Byers TE. First pregnancy characteristics and subsequent breast cancer risk among young women. Int J Cancer 2004; 112(2):306-11.
  65. Vatten LJ, Forman MR, Nilsen TI, Barrett JC, Romundstad PR. The negative association between pre-eclampsia and breast cancer risk may depend on the offspring's gender. Br J Cancer 2007; 96(9):1436-8.
  66. Terry MB, Perrin M, Salafia CM, Zhang FF, Neugut AI, Teitelbaum SL, et al. Preeclampsia, pregnancy-related hypertension, and breast cancer risk. Am J Epidemiol 2007; 165(9):1007-14.
  67. Richardson BE, Peck JD, Wormuth JK. Mean arterial pressure, pregnancy-induced hypertension, and preeclampsia: evaluation as independent risk factors and as surrogates for high maternal serum α-fetoprotein in estimating breast cancer risk. Cancer Epidemiol Biomarkers Prev 2000; 9(12):1349-55.
  68. Cnattingius S, Torrång A, Ekbom A, Granath F, Petersson G, Lambe M. Pregnancy characteristics and maternal risk of breast cancer. JAMA 2005; 294(19):2474-80.
  69. Brasky TM, Li Y, Jaworowicz DJ Jr, Potischman N, Ambrosone CB, Hutson AD, et al. Pregnancy-related characteristics and breast cancer risk. Cancer Causes Control 2013; 24(9):1675-85.
  70. Ma H, Henderson KD, Sullivan-Halley J, Duan L, Marshall SF, Ursin G, et al. Pregnancy-related factors and the risk of breast carcinoma in situ and invasive breast cancer among postmenopausal women in the California Teachers Study cohort. Breast Cancer Res 2010; 12(3):R35.
  71. Troisi R, Doody DR, Mueller BA. A linked-registry study of gestational factors and subsequent breast cancer risk in the mother. Cancer Epidemiol Biomarkers Prev 2013; 22(5):835-47.
  72. Paltiel O, Friedlander Y, Tiram E, Barchana M, Xue X, Harlap S. Cancer after pre-eclampsia: follow up of the Jerusalem perinatal study cohort. BMJ 2004; 328(7445):919.
  73. Calderon-Margalit R, Friedlander Y, Yanetz R, Deutsch L, Perrin MC, Kleinhaus K, et al. Preeclampsia and subsequent risk of cancer: update from the Jerusalem Perinatal Study. Am J Obstet Gynecol 2009; 200(1):63.e1-5.
  74. Guariguata L, Linnenkamp U, Beagley J, Whiting DR, Cho NH. Global estimates of the prevalence of hyperglycaemia in pregnancy. Diabetes Res Clin Pract 2014; 103(2):176-85.
  75. Ferrara A. Increasing prevalence of gestational diabetes mellitus. Diabetes Care 2007; 30(Suppl 2):S141-6.
  76. Jafari-Shobeiri M, Ghojazadeh M, Azami-Aghdash S, Naghavi-Behzad M, Piri R, Pourali-Akbar Y, et al. Prevalence and risk factors of gestational diabetes in Iran: a systematic review and meta-analysis. Iran J Public Health 2015; 44(8):1036-44.
  77. American Diabetes Association. (2) Classification and diagnosis of diabetes. Diabetes Care 2015; 38(Suppl 1):S8-16.
  78. Xue F, Michels KB. Diabetes, metabolic syndrome, and breast cancer: a review of the current evidence. Am J Clin Nutr 2007; 86(3):823S-35.
  79. Baxter RC. IGF binding proteins in cancer: mechanistic and clinical insights. Nat Rev Cancer 2014; 14(5):329-41.
  80. Pollak M. The insulin and insulin-like growth factor receptor family in neoplasia: an update. Nat Rev Cancer 2012; 12(3):159-69.
  81. Lee AV, Zhang P, Ivanova M, Bonnette S, Oesterreich S, Rosen J, et al. Developmental and hormonal signals dramatically alter the localization and abundance of insulin receptor substrate proteins in the mammary gland. Endocrinology 2003; 144(6):2683-94.
  82. Perrin MC, Terry MB, Kleinhaus K, Deutsch L, Yanetz R, Tiram E, et al. Gestational diabetes and the risk of breast cancer among women in the Jerusalem Perinatal Study. Breast Cancer Res Treat 2008; 108(1):129-35.
  83. Fuchs O, Sheiner E, Meirovitz M, Davidson E, Sergienko R, Kessous R. The association between a history of gestational diabetes mellitus and future risk for female malignancies. Arch Gynecol Obstet 2017; 295(3):731-36.
  84. Park YM, O'Brien KM, Zhao S, Weinberg CR, Baird DD, Sandler DP. Gestational diabetes mellitus may be associated with increased risk of breast cancer. Br J Cancer 2017; 116(7):960-3.
  85. Dawson SI. Long‐term risk of malignant neoplasm associated with gestational glucose intolerance. Cancer 2004; 100(1):149-55.
  86. Sella T, Chodick G, Barchana M, Heymann AD, Porath A, Kokia E, et al. Gestational diabetes and risk of incident primary cancer: a large historical cohort study in Israel. Cancer Causes Control 2011; 22(11):1513-20.
  87. Powe CE, Tobias DK, Michels KB, Chen WY, Eliassen AH, Manson JE, et al. History of gestational diabetes mellitus (GDM) and risk of incident invasive breast cancer among parous women in the Nurses' Health Study II prospective cohort. Cancer Epidemiol Biomarkers Prev 2016; 25(3):321-7.
  88. Bejaimal SA, Wu CF, Lowe J, Feig DS, Shah BR, Lipscombe LL. Short‐term risk of cancer among women with previous gestational diabetes: a population‐based study. Diabet Med 2016; 33(1):39-46.
  89. Rollison DE, Giuliano AR, Sellers TA, Laronga C, Sweeney C, Risendal B, et al. Population-based case-control study of diabetes and breast cancer risk in Hispanic and non-Hispanic White women living in US southwestern states. Am J Epidemiol 2007; 167(4):447-56.
  90. Fell DB, Joseph K. Temporal trends in the frequency of twins and higher-order multiple births in Canada and the United States. BMC Pregnancy Childbirth 2012; 12:103.
  91. Hall JG. Twinning. Lancet 2003; 362(9385):735-43.
  92. Batra S, Sjoberg NO, Aberg A. Human placental lactogen, estradiol-17β, and progesterone levels in the third trimester and their respective values for detecting twin pregnancy. Am J Obstet Gynecol 1978; 131(1):69-72.
  93. Wald N, Cuckle H, Wu TS, George L. Maternal serum unconjugated oestriol and human chorionic gonadotrophin levels in twin pregnancies: implications for screening for Down's syndrome. Br J Obstet Gynaecol 1991; 98(9):905-8.
  94. Jacobson HI, Lemanski N, Narendran A, Agarwal A, Bennett JA, Andersen TT. Hormones of pregnancy, α-feto protein, and reduction of breast cancer risk. Adv Exp Med Biol 2008; 617:477-84.
  95. Lambe M, Hsieh C, Tsaih S, Ekbom A, Adami HO, Trichopoulos D. Maternal risk of breast cancer following multiple births: a nationwide study in Sweden. Cancer Causes Control 1996; 7(5):533-8
  96. Albrktsen G, Heuch I, Kvåle G. Multiple births, sex of children and subsequent breast‐cancer risk for the mothers: a prospective study in Norway. Int J Cancer 1995; 60(3):341-4.
  97. Neale RE, Darlington S, Murphy MF, Silcocks PB, Purdie DM, Talbäck M. The effects of twins, parity and age at first birth on cancer risk in Swedish women. Twin Res Hum Genet 2005; 8(2):156-62.
  98. Ji J, Fôrsti A, Sundquist J, Hemminki K. Risks of breast, endometrial, and ovarian cancers after twin births. Endocr Relat Cancer 2007; 14(3):703-11.
  99. Neale RE, Purdie DM, Murphy MF, Mineau GP, Bishop T, Whiteman DC. Twinning and the incidence of breast and gynecological cancers (United States). Cancer Causes Control 2004; 15(8):829-35.
  100. Kelsey JL, Gammon MD, John EM. Reproductive factors and breast cancer. Epidemiol Rev 1993; 15(1):36-47.
  101. Russo J, Moral R, Balogh GA, Mailo D, Russo IH. The protective role of pregnancy in breast cancer. Breast Cancer Res 2005; 7(3):131-42.
  102. Guo J, Huang Y, Yang L, Xie Z, Song S, Yin J, et al. Association between abortion and breast cancer: an updated systematic review and meta-analysis based on prospective studies. Cancer Causes Control 2015; 26(6):811-9.
  103. Huang Y, Zhang X, Li W, Song F, Dai H, Wang J, et al. A meta-analysis of the association between induced abortion and breast cancer risk among Chinese females. Cancer Causes Control 2014; 25(2):227-36.
  104. Kim JS, Kang EJ, Woo OH, Park KH, Woo SU, Yang DS, et al. The relationship between preeclampsia, pregnancy-induced hypertension and maternal risk of breast cancer: a meta-analysis. Acta Oncol 2013; 52(8):1643-8.
  105. Sun M, Fan Y, Hou Y, Fan Y. Preeclampsia and maternal risk of breast cancer: a meta-analysis of cohort studies. J Matern Fetal Neonatal Med 2017; 17:1-8.
  106. Tong GX, Cheng J, Chai J, Geng QQ, Chen PL, Shen XR, et al. Association between gestational diabetes mellitus and subsequent risk of cancer: a systematic review of epidemiological studies. Asian Pac J Cancer Prev 2014; 15(10):4265-9.


Kim HS, Woo OH, Park KH, Woo SU, Yang DS, Kim AR, et al. The relationship between twin births and maternal risk of breast cancer: a meta-analysis. Breast Cancer Res Treat 2012; 131(2):671-7.

مجله زنان، مامایی و نازایی ایران
دوره 21، شماره 2
اردیبهشت 1397
صفحه 85-97