مجله زنان، مامایی و نازایی ایران

مجله زنان، مامایی و نازایی ایران

کاربرد سلولهای بنیادی در درمان اختلالات تولید مثلی مردان و زنان: مقاله مروری

نوع مقاله : مروری

نویسندگان
نازنین رضائی 1
صبا فرضی 2
حمید تقی‌نژاد 3
مهناز شفیعیان 4
صفورا طاهری 5
1 کارشناس ارشد مامایی، مرکز تحقیقات تعیین کننده‌های اجتماعی سلامت، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی ایلام، ایلام، ایران.
2 دانشجوی دکترای تخصصی پرستاری، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران.
3 استادیار گروه پرستاری، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی ایلام، ایلام، ایران.
4 کارشناس ارشد مامایی، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی ایلام، ایلام، ایران.
5 دانشجوی دکترای تخصصی بهداشت باروری، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی تهران، تهران، ایران. کارشناس ارشد مامایی، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی ایلام، ایلام، ایران.
10.22038/ijogi.2017.9866
چکیده
مقدمه: سلول‌های بنیادی به آن دسته از سلول‌های بدن اطلاق می‌شود که هنوز تمایز نیافته و دارای قدرت خود تکثیری بوده و قابلیت تمایز و تبدیل به انواع دیگر سلول‌های بدن را دارند. با توجه به اهمیت و حساسیت باروری در جوامع بشری و تلاش جهت چاره‌جویی برای کاهش اختلالات باروری در مردان و زنان، مطالعه مروری حاضر با هدف بررسی کاربرد سلول­های بنیادی در درمان اختلالات تولیدمثلی زنان و مردان انجام شد.
روش‌کار: در این مطالعه مروری، اطلاعات مربوط به کاربرد سلول­های بنیادی در درمان اختلالات تولید مثلی مردان و زنان از پایگاه‌های اطلاعاتی نظیر SID، Magiran، PubMed، Irandoc، Iranmedx Scopus، Google Scholar  و web of science با استفاده از کلید واژه­های فارسی: سلول‌های بنیادی، اختلالات تولیدمثلی، مردان و زنان و کلید واژه­های انگلیسی women، reproductive disordersmen، stem cell و infertility بدون محدودیت زمانی جستجو شد. تجزیه و تحلیل داده­ها به صورت کیفی انجام شد. در نهایت برای تنظیم مقاله از 48 مقاله به زبان فارسی و انگلیسی استفاده گردید.
یافته‌ها: استفاده از سلول­های بنیادی تخمدان و رحم و سلول‌های بنیادی اسپرماتوگونیال در درمان ناباروری ناشی از شیمی‌درمانی، بیماری­های اتوایمیون، بیماری­های مرتبط با کروموزوم X، خطرات محیطی، اندومتریوز نوجوانی یا کیست­های تخمدانی و کانسرهای تخمدانی قبل از یائسگی، حفظ باروری، پیشگیری از انتقال بیماری‌های ژنتیکی از کاربردهای سلول­های بنیادی در علوم پزشکی می­باشد که تعدادی از آنها در حیوانات و انسان و تعدادی دیگر فقط در حیوانات مورد بررسی و تأیید قرار گرفته است.
نتیجه‌گیری: سلول­های بنیادی می­توانند در درمان اختلالات تولیدمثلی زنان و مردان کاربردهای بسیاری داشته باشند، حال آنکه در مسیر استفاده از سلول­های بنیادی در نمونه­های انسانی چالش­های تکنیکی و اخلاقی وجود دارد که نیازمند تأمل بیشتری می­باشد.
کلیدواژه‌ها
حفظ باروری
ناباروری
سلول‌های بنیادی
زنان
مردان

عنوان مقاله English

Application of stem cells in the treatment of reproductive disorders in men and women: review article

نویسندگان English

Nazanin Rezaei 1
Saba Farzi 2
Hamid Taghinejad 3
Mahnaz Shafieian 4
Safoura Taheri 5
1 M.Sc. of Midwifery, Social Determinants of Health Research Center, School of Nursing & Midwifery, Ilam University of Medical Sciences, Ilam, Iran.
2 Phd student of Nursing, School of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran.
3 Assistant Professor, Department of Nursing, School of Nursing and Midwifery, Ilam University of Medical Sciences, Ilam, Iran.
4 M.Sc. of Midwifery, School of Nursing & Midwifery, Ilam University of Medical Sciences, Ilam, Iran.
5 PhD student of Reproductive Health, School of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, Iran. M.Sc. of Midwifery, School of Nursing & Midwifery, Ilam University of Medical Sciences, Ilam, Iran.
چکیده English

Introduction: Stem cells refer to those body's cells which are still undifferentiated and have proliferative power and the ability to differentiate into other types of cells in the body. Considering the importance and sensitivity of fertility in human societies and efforts to search for a solution to reduce fertility disorders in men and women, this review study was performed with aim to evaluate the application of stem cells in the treatment of reproductive disorders in women and men.
Methods: In this review study, the information on the use of stem cells in the treatment of reproductive disorders in men and women was searched in databases such as SID, Magiran, PubMed, Irandoc, Iranmedx Scopus, Google scholar, web of science using the keywords of stem cells, infertility, reproductive disorders, men and women without time limitation. Data analysis was carried out qualitatively. Finally, 48 papers in English and Persian were used for the regulation of the article.
Results: The ovarian and uterine  stem cells and Spermatogonial stem cells in the treatment of infertility caused by chemotherapy, autoimmune diseases, diseases associated with X chromosome, environmental hazards, adolescence endometriosis or ovarian cysts and ovarian cancer before menopause, fertility preservation, prevention of transmission of genetic diseases are from the application of stem cells in medical sciences that some of them has been reviewed and approved in animals and humans, and some only in animals.
Conclusion: Stem cells can be used in the treatment of reproductive disorders in women and men; however there are technical and ethical challenges in the use of stem cells in human samples which need more contemplation.

کلیدواژه‌ها English

Fertility preservation
Infertility
Men
Stem cells
Women oil
Iranian Traditional Medicine
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مجله زنان، مامایی و نازایی ایران
دوره 20، ویژه نامه
آذر 1396
صفحه 78-96