نوع مقاله : اصیل پژوهشی
1 دانشیار گروه بیوشیمی و ژنتیک، دانشکده پزشکی، دانشگاه علوم پزشکی اراک، اراک، ایران.
2 استاد گروه بیوشیمی، دانشکده پزشکی، دانشگاه علوم پزشکی لرستان، لرستان، ایران.
عنوان مقاله [English]
Introduction: There are low and conflicting data about the relationships between homocysteine, adiponectin/ homocysteine ratio and uric acid with insulin resistance indexes in gestational diabetes mellitus (GDM). Therefore, this study was performed with aim to evaluate serum values of homocysteine, adiponectin, adiponectin/ homocysteine ratio and uric acid and their relationships with insulin resistance index in GDM compared with normal pregnancy.
Methods: This cross-sectional study was performed on 30 women with GDM and 30 normal pregnant women referred to Asalian hospital of Khorramabad during 2013-2014. Serum levels of glucose and uric acid were measured by photometric method and serum levels of homocysteine, adiponectin and insulin were measured by ELISA method. Data was analyzed by independent t-test and Pearson’s correlation analysis. PResults: Serum levels of homocysteine were significantly increased in GDM compared with normal pregnant women (P<0.001); while levels of adiponectin (P=0.003) and adiponectin/ homocysteine ratio (P=0.001) were significantly decreased. There was no significant difference in uric acid level between two groups. Significant and direct correlation was observed between levels of homocysteine and insulin with GDM (r=0.40, P=0.031). There was significant and direct correlation between levels of uric acid with insulin resistance index in experimental group (r=0.38, P=0.041). An indirect and significant correlation was observed between adiponectin/ homocysteine ratio and fasting blood glucose in normal control group (r= -0.39, P=0.035).
Conclusion: Increased serum values of homocysteine and decreased values of adiponectin/ homocysteine ratio and lightly increased levels of uric acid could be considered as risk factors for insulin resistance in GDM.
Angarita FA, Chesney T, Elser C, Mulligan AM, McCready DR, Escallon J. Treatment patterns of elderly breast cancer patients at two Canadian cancer centers. Eur J Surg Oncol 2015; 41(5):625-34.