بررسی ارتباط آندومتریوز و بروز اختلالات فشارخون حاملگی در زنان نخست زا

نوع مقاله : اصیل پژوهشی

نویسندگان

1 دانشیار گروه زنان و مامایی، دانشکده پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران.

2 مربی گروه پرستاری مامایی، مرکز تحقیقات سلامت زنان، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران.

3 دستیار گروه چشم پزشکی، دانشکده پزشکی، دانشگاه علوم پزشکی تهران، تهران، ایران.

چکیده

مقدمه: آندومتریوز یکی از بیماری‌های شایع سنین باروری و پره اکلامپسی یک بیماری سیستمیک با درگیری ارگان‌های مختلف است که خطرات زیادی برای مادر به ویژه در سندرم HELLP و اکلامپسی و برای جنین به دنبال دارد. نتایج متناقضی از مطالعات در زمینه ارتباط آندومتریوز و اختلالات هیپرتانسیو بارداری گزارش شده است. بنابراین با توجه به زمینه مشترک فعالیت آنژیوژنز در دو اختلال آندومتریوز و پره اکلامپسی، مطالعه حاضر با هدف بررسی فراوانی پره اکلامپسی و اختلالات هیپرتانسیون بارداری در زنان نخست زا مبتلا به آندومتریوز و افراد سالم انجام شد.
روش کار: در این مطالعه کوهورت تاریخی پرونده‌های 893 زن که به دلیل ناباروری طی سال‌های 86-1382 در بیمارستان‌های الزهرا (س)، شهید بهشتی و مرکز باروری و ناباروری اصفهان تحت عمل لاپاروسکوپی قرار گرفته بودند، استخراج شد. 101 بیمار مبتلا به آندومتریوز و 101 نفر از افراد غیر مبتلا به آندومتریوز در هر گروه وارد و ابتلاء به پره اکلامپسی و فشارخون بارداری، در حاملگی بعد از انجام لاپاراسکوپی در دو گروه مقایسه شد. تجزیه و تحلیل داده‌ها با استفاده از نرم افزار آماریSPSS  (نسخه 16) و آزمون‌های کای اسکوئر، تی دانشجویی و تست دقیق فیشر انجام شد. میزان p کمتر از 05/0 معنی دار در نظر گرفته شد.
یافته ها: در این مطالعه ارتباط معنی داری بین آندومتریوز با پره اکلامپسی و هیپرتانسیون بارداری وجود نداشت (5/0=p). 2 نفر (2%) از زنان مبتلا به آندومتریوز و 3 نفر (3%) از زنان غیر مبتلا به آندومتریوز به پره اکلامپسی مبتلا بودند. فراوانی فشارخون بارداری در زنان مبتلا به آندومتریوز 9/6% و در زنان بدون آندومتریوز 9/8% به دست آمد که این اختلاف نیز از نظر آماری معنی دار نبود (3/0=p).
نتیجه گیری: فراوانی آندومتریوز و اختلالات فشارخون بارداری در زنان با و بدون سابقه آندومتریوز تفاوتی با هم ندارد و سابقه آندومتریوز با افزایش اختلالات هیپرتانسیو بارداری همراه نمی باشد.

کلیدواژه‌ها

عنوان مقاله [English]

Association between endometriosis and pregnancy hypertension disorders in nulliparous women

نویسندگان [English]

  • Farahnaz Mardanian 1
  • Maryam Kianpour 2
  • Elaheh Sharifian 3
1 Associate Professor, Department of Obstetrics and Gynecology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
2 Instructor of Nursing and Midwifery, Women's Health Research Center, School of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran.
3 Resident of Ophthalmology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
چکیده [English]

Introduction: Endometriosis is one of the common diseases of reproductive age and preeclampsia is a systemic disease with different organs involvement that has much risk for mother especially in HELLP syndrome and eclampsia and for fetus. There are controversy reports about association between endometriosis and pregnancy hypertension disorders. Therefore, regarding to the common background of angiogenesis activity in two disorders of endometriosis and preeclampsia, this study was performed with aim to determine the frequency of preeclampsia and pregnancy hypertension disorders in nulliparous women with endometriosis and the healthy women.
Methods: In this historical cohort study, the files of 893 infertile women who had referred to Alzahra and Beheshti hospitals and Fertility and Infertility center of Isfahan and had undergone laparoscopy due to infertility during 1993-1997 were extracted. 101 women were assigned in each group and preeclampsia and pregnancy hypertension disorders were compared between two groups after laparoscopy. Data were analyzed using SPSS software (version 16), and Fisher Exact, t-test, and Chi-square tests. PResults: There was no significant association between endometriosisand preeclampsia and pregnancy hypertension disorders (P=0.5). 2 women (2%) with endometriosis and 3 (3%) without endometriosis had preeclampsia. Frequency of pregnancy hypertension in women with endometriosis was 6.9% and in women without endometriosis was 8.9% and the difference was not significant (P=0.3).
Conclusion: Frequency of endometriosis and pregnancy hypertension disorders was not different in women with endometriosis and women without endometriosis and the history of endometriosis is not associated with pregnancy hypertension disorders.

کلیدواژه‌ها [English]

  • Endometriosis
  • Epidemiology
  • Preeclampsia
  • Pregnancy hypertension

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مجله زنان، مامایی و نازایی ایران
دوره 19، شماره 7
هفته سوم اردیبهشت ماه 1395
اردیبهشت 1395
صفحه 1-8

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