مجله زنان، مامایی و نازایی ایران

مجله زنان، مامایی و نازایی ایران

مرور کلی بر پاپیلوما ویروس ها به عنوان اصلی ترین عامل سرطان دهانه رحم

نوع مقاله : مروری

نویسندگان
امیر سهرابی 1
مرجان رهنمای فرزامی 2
سیامک میراب سمیعی 3
محمد حسین مدرسی 4
1 استادیار گروه بیولوژی مولکولی، مرکز تحقیقات آزمایشگاه رفرانس، آزمایشگاه مرجع سلامت وزارت بهداشت، درمان و آموزش پزشکی، تهران، ایران.
2 استادیار مرکز تحقیقات آزمایشگاه رفرانس، آزمایشگاه مرجع سلامت وزارت بهداشت، درمان و آموزش پزشکی، تهران، ایران.
3 استادیار آزمایشگاه مرجع سلامت وزارت بهداشت، درمان و آموزش پزشکی، تهران، ایران.
4 استاد گروه ژنتیک پزشکی، دانشکده پزشکی، دانشگاه علوم پزشکی تهران، تهران، ایران.
10.22038/ijogi.2015.4394
چکیده
مقدمه: سرطان دهانه رحم مرتبط با پاپیلوما ویروس ها به عنوان شایع ترین سرطان زنان به صورت یک معضل بهداشتی در سراسر دنیا خصوصاً در کشورهای در حال توسعه مطرح می باشد. ژنوتیپ های مختلف پاپیلوما ویروس های انسانی خصوصاً ژنوتیپ های پرخطر به عنوان عامل اصلی این سرطان و دیگر سرطان های انسانی نظیر: دستگاه تناسلی، پوست، سر و گردن و غیره مطرح هستند. مطالعه حاضر با هدف افزایش آگاهی در مورد ساختار، بیماری زایی و تشخیص پاپیلوما ویروس ها انجام شد.
روش کار: مرور مستندات در مطالعه مروری حاضر با جستجو در پایگاه های علمی معتبر خارجی و داخلی و با استفاده از کلمات کلیدی مرتبط صورت گرفت. در این مطالعه سعی شده است با استفاده از مقالات منتشر شده در این پایگاه های علمی به بررسی نقش ژنوتیپ های مختلف پاپیلوما ویروس ها در ایجاد عفونت های مختلف از جمله سرطان دهانه رحم و روش های تشخیصی موجود در جهت ژنوتایپینگ این دسته از ویروس ها پرداخته شود.
یافته ها: افزایش دانش روز افزون درباره نقش مهم و اساسی پاپیلوما ویروس ها در سرطان زایی آنها منجر به بهبود روش های نوین تشخیصی مولکولی همراه با بیومارکرهای مولکولی در ژنوتایپینگ پاپیلوما ویروس ها خواهد شد.
نتیجه گیری: گسترش روز افزون عفونت های تناسلی، بیماری های مقاربتی و سرطان های ناشی از میکروارگانیسم ها به خصوص پاپیلوما ویروس، همکاری جوامع جهانی در انجام مطالعات جامع تر به خصوص در کشورهای در حال توسعه را می طلبد. آموزش همگانی، توسعه غربالگری کلاسیک همراه با روش های نوین تشخیصی، بهترین ابزار در تعیین خط مشی در استراتژی های درمانی و پیشگیری کننده چون واکسن بر علیه سرطان های مرتبط با پاپیلوما ویروس ها در کشورهای در حال توسعه خواهد بود.
کلیدواژه‌ها
پاپیلوما ویروس
سرطان دهانه رحم
ایران

عنوان مقاله English

An Overview on Papillomaviruses as the Main Cause of Cervical Cancer

نویسندگان English

Amir Sohrabi 1
Marjan Rahnamaye Farzami 2
Siamak Mirab Samiee 3
Mohammad Hossein Modarresi 4
1 Assistant Professor, Department of Molecular Biology, Reference Laboratory Research Center, Reference Laboratory of Ministry of Health and Medical Education, Tehran, Iran.
2 Assistant Professor, Reference Laboratory Research Center, Reference Laboratory of Ministry of Health and Medical Education, Tehran, Iran.
3 Assistant Professor, Reference Laboratory of Ministry of Health and Medical Education, Tehran, Iran.
4 Professor, Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
چکیده English

Introduction: Cervical cancer associated with Papillomaviruses has been suggested as the most common cancer and a big problem around the world, especially in developing countries. Different genotypes of Human Papillomaviruses (HPV) especially high risk genotypes are considered as the main cause of this cancer and other human cancers such as genital track, skin, head and neck and etc. This study was performed with aim to increase the awareness about the structure, pathogenesis and diagnosis of papillomaviruses.
Methods: In this review study, valid internal and external databases and the related keywords were used. In this study, it has been tried to use the published article in these scientific databases and evaluate the role of different Papillomaviruses genotypes in causing infections such as cervical cancer and diagnostic methods for genotyping of these viruses.
Results: Increasing knowledge about the important and basic role of Papillomaviruses in causing cancers will lead to improvement of novel molecular diagnostic methods along with molecular biomarkers in genotyping of Papillomaviruses.
Conclusion: Increasing rate of genital infections, sexually transmitted diseases and cancers caused by micro-organisms, especially HPV demands the cooperation of international communities to do more comprehensive studies, especially in developing countries. Public education, development of classic screening along with diagnostic novel methods will be the best tool to determine the policies in medical and preventive strategies such as vaccine against the cancers related to Papillomaviruses.

کلیدواژه‌ها English

Cervical Cancer
Iran
Papillomavirus
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مجله زنان، مامایی و نازایی ایران
دوره 18، شماره 145 - شماره پیاپی 145
هفته سوم اردیبهشت ماه 1394
اردیبهشت 1394
صفحه 14-25