بررسی تأثیر گیاهان دارویی در درمان گرگرفتگی دوران یائسگی به روش مرور سیستماتیک و متاآنالیز (مطالعات کارآزمایی بالینی) در ایران

نوع مقاله : اصیل پژوهشی

نویسندگان

1 دانشجوی کارشناسی مامایی، کمیته تحقیقات دانشجویی، دانشکده پرستاری مامایی، دانشگاه علوم پزشکی ایلام، ایلام، ایران.

2 مربی گروه مامایی، دانشکده پرستاری مامایی، دانشگاه علوم پزشکی ایلام، ایلام، ایران.

3 کارشناس ارشد بیوشیمی، مرکز تحقیقات میکروب شناسی بالینی، دانشکده پزشکی، دانشگاه علوم پزشکی ایلام، ایلام، ایران.

4 استادیار گروه آمار زیستی، مرکز تحقیقات پیشگیری از آسیب های روانی اجتماعی، دانشکده پزشکی، دانشگاه علوم پزشکی ایلام، ایلام، ایران.

چکیده

مقدمه: شایع ترین عارضه دوران یائسگی گرگرفتگی می باشد. امروزه استفاده از داروهای گیاهی در درمان عوارض یائسگی از جمله گرگرفتگی مورد توجه قرار گرفته است. مطالعه حاضر با هدف بررسی تأثیر گیاهان دارویی مورد استفاده در درمان گرگرفتگی انجام شد.
روش کار: مطالعه حاضر یک مطالعه مرور سیستماتیک و فرا تحلیل است. اطلاعات در مورد تأثیر داروهای گیاهی بر گرگرفتگی دوران یائسگی از پایگاه ‌های اطلاعاتی Google scholar، IranMedex، Magiran، MedLib، PubMed، SID و IranDoc  جستجو شد. در نهایت 16 مقاله در فاصله سال‌ های 1379تا 1391 در ایران انتخاب شد. داده ها با نرم افزارSTATA  (نسخه 12/2) و با استفاده از روش متاآنالیز، مدل اثرات تصادفی با هم ترکیب شدند.
یافته‌ها: از بین 16 مقاله، 15 مطالعه کاهش تعداد گرگرفتگی را مورد بررسی قرار داده بودند. در گروه گیاهان دارویی میانگین کاهش تعداد گرگرفتگی، /085- (فاصله اطمینان 95%: از 1/83- تا 0/12) کمتر از گروه شاهد بود که این میزان کاهش از نظر آماری معنی دار بود (0/05>p). شدت گرگرفتگی ها نیز کاهش چشمگیری داشته است؛ به گونه ای که شدت گرگرفتگی شدید 0/81- (فاصله اطمینان 95%: از 1/86- تا 0/23)( 0/126=p)و گرگرفتگی متوسط 0/85- (فاصله اطمینان 95%: از 1/83- تا 0/12) کمتر از گروه شاهد بود که از نظر آماری معنی دار بود (0/087=p).
نتیجه‌گیری: گیاهان دارویی حاوی فیتواستروژن ها، تأثیر بسیار خوبی بر کاهش تعداد دفعات و شدت گرگرفتگی زنان یائسه دارند و انتخاب مناسبی برای درمان گرگرفتگی زنان یائسه، به جای هورمون درمانی جایگزینی می باشند.

کلیدواژه‌ها

عنوان مقاله [English]

Effect of Herbaceous Medicines effective in hot flashes of Menopause women: a systematic Review and Meta-Analysis in Iran

نویسندگان [English]

  • Latifeh Heydari 1
  • Zainab Suhrabi 2
  • Fatemeh Sayehmiri 3
  • Kourosh Sayehmiri 4
1 B.Sc. Student of Midwifery, Student Research Committee, Faculty of Nursing and Midwifery, Ilam University of Medical Sciences, Ilam, Iran.
2 Lecture of Midwifery, Faculty of Nursing and Midwifery, Ilam University of Medical Sciences, Ilam, Iran.
3 M.sc of Biochemistry, Clinical Microbiology Research Center, Ilam University of Medical Sciences, Ilam, Iran.
4 Assistant Professor, Department of Biostatistics, Prevention of psychosocial impairment Research Center, Ilam University of Medical Sciences, Ilam, Iran.
چکیده [English]

Introduction: The most common phenomenon of menopause period is hot Flashes. nowadays using herbaceous medicines in hot Flashes treatment has gained much attention. The aim of this study is to investigate the effect of herbaceous medicines in hot Flashes treatment.
Methods: Current study is a systematic and Meta-analysis review. Information about the effect of herbaceous medicines on hot Flashes in menopause period collected from Google scholar, IranMedex, Magiran, MedLib, PubMed, SID, IranDoc databases. 16 articles published between 2000 and 2009 worldwide were selected. Data were analysed by STATA software (version12.2) using Meta-analysis method (random selection model).
Results: of 16 articles, 15 one were evaluated the reduction of hot Flashes. In herbaceous medicines group, the average of reduction of hot Flashes was 0.85 (CI 95%: 1.83-0.12) lower than the control group which was significant, statistically. The intensity of hot Flashes also significantly reduced. The severe and medium hot Flashes was 0.81( CI 95%: 1.86-0.23) and 0.85 ( CI 95%: 1.83-0.12) lower than control group, respectively which was statistically significant.
Conclusion: Herbaceous Medicines contain phytoestrogens, have a positive effect on reducing the frequency and severity of hot Flashes and They are the best choise for the treatment of hot Flashes in menopausal women and in hormone replacement therapy.

کلیدواژه‌ها [English]

  • Herbals
  • hot flashes
  • Menopause
  • Meta-analysis

مراجع

  1. Rajaeefard A, mohamadbeygi A, mohammadsalehi N. The estimated mean age at menopause in Iranian women: a study Mtanalyz. Komesh 13. 2011;1(41).
  2. Speroff L, Marc A, Fritz M. Menopause and the perimenopausal transition. In: Clinical gynecologic and infertility.8th ed. Philadelphia: Lippincot Williams & Wilkinsc2011. 643- 57 p.
  3. Nanbakhsh F, Mohadesi H, Mirabi A, Hagishafieiha M, Bromand F, Bahadori F, et al. Elderly health effects of education on knowledge, attitude and practice of older women. Journal of Faculty of Tehran University of Medical Sciences (payavard salamat). 2011;5(1):47-57.
  4. Rogerio A. Treatment of the postmenopausal woman.2th ed. 1999:157-8, 581.
  5. Ryan K. Kistner Gynecology and Woman's H ealth.7 th ed 1999:540 -5.
  6. Berek G. Berek and Novaks gynecology, 15th,. Philadelphia: Lippincott Williams & Wilkins. c2012:1115-7.
  7. Fernandez E, Gallus S, Bosetti C, Franceschi S, Negri E, VECCHIA CL. Hormone replacement therapy and cancer risk: a systematic analysis from a network of case_ control studies. Wiley-Liss, Inc Int J Cancer. 2003;105:408–12.
  8. Rahimikian F, SHahnaz G, Abbas M, Aezam B. Assessment the rate of use or refusal of hormon replacement therapy in menopausal women referred to gynecology clinics, in selected hospitals of Tehran University Medical Sciences. Hayat: J FacultNursMidwif Tehran Univ Med Sci 2002;8(15):53-61.
  9. Taylor M. Botanicalls: Medicines and menopause. ClinObstetGynecol 2001;44(4):853-63.
  10. Cheema D, Coomarasamy A, El-Toukhy T. Non-hormonal therapy of post-menopausal vasomotor symptoms: a structured evidence-based review Arch Gynecol Obstet. 2007; 276:463-9
  11. Davis S, Mukies A, Wilcox G. Phytoestrogens in clinical practice. Integrative Medicine. 1998;1(1):27-34.
  12. Knight D, Eden J. Phytoestrogens -a short review. Maturitas J of the climacteric &postmenopause. 1995;22:167- 75.
  13. Warren M. The effect of phytoestrogen supplementation in post menopausal women. J Soc Gynecol investing 2002;9(4):184-5.
  14. Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JPA, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ online. 2009;339(b2700).
  15. Mirabia P, Mojabb F. The Effects of Valerian Root on Hot Flashes in Menopausal Women Iranian Journal of Pharmaceutical Research. 2013;12(1):217-22.
  16. Baghdari N, KHoshbin A, Ayati S, Emami A, Ismili H. The effect of flaxseed on hot flashes in menopausal women surrounding. Iranian Journal of Obstetrics, Gynecology and Infertility. 2011;14(1):37-47.
  17. Nahidi F, Zare E, Mojab F, Majd HA. The effect of Licorice root extract on hot flashes in menopause[Article in Persian]. Pejouhandeh. 2011;16(1):11-7.
  18. Nahidi F, Zare E, Mojab F, Majd HA. Effect of licorice root on the number of hot flashes in postmenopausal women Bane[Article in Persian]. sbmu. 2009;19(67):21-5.
  19. Kazemian A, Sereshti M, Foruzandeh N, Akbari N. Effect of Passion Flower on hot flashes in menopausal women covered Health centers in Isfahan. Journal of Ilam University of Medical Sciences. 2006;14(2):41-7.
  20. Kazemian A, Banaian S, Parvin N, Delaram M. The effect of valerian on hot flash in menopausal women. J Shahrekord Univ Med Sci. 2006;8(2):35-40.
  21. Abdolahi F, Azadbakht M, Shabankhani B, Abhari FR, Mosledmizadeh N. Effect of aqueous Glycyrrhza globra extract on menopausal symptoms. J Mazandaran Uni Med. 2006;16(56):75-82.
  22. Sekhavat L, Firozabadi RD. Effect of soy protein on the symptoms of hot flashes in women Menopause in Yazd city from the year 1386 - 1388. IJOGI. 2012;15(6):10-5.
  23. AbbasPour Z, HajiKhani N, Afshari P. Effect of Vitex Agnus-Castus on early menopausal symptoms in postmenopausal women. J Sabzevar Uni Med Sci. 2005;12(2):26-30.
  24. Abbaspour Z, Nik FM, Moghadam AZ, Saadati N, Latifi S. A study on effect of isolated soy on hot flashes of menopausal women. Sci Med J. 2003(36):18-25.
  25. Kazemian A, Brumandfar K, Ghanadi A, Nurian K. Effect of Vitagnus and Passi-pay on hot flash of menopausal women. J Shahrekord Univ Med Sci. 2005;7(1):39-45.
  26. Nahidi F, Taherpour M, Mojab F, Majd HA. Effects of Anise abstract on menopausal hot flashes. Pejouhandeh. 2008;13(3):167-73.
  27. Nahidi F, Kariman N, Simbar M, Mojab F. The Study on the Effects of Pimpinella anisum on Relief and Recurrence of Menopausal Hot Flashes. Iranian Journal of Pharmaceutical Research. 2012;11(4):1079-85.
  28. Nahidi F, Zare E, Mojab F, Alavi-majd H. Effects of Licorice on Relief and Recurrence of Menopausal Hot Flashes. ServicesIranian Journal of Pharmaceutical Research. 2012;11(2):541-8.
  29. SadeghiAvvalshahr H, Bakhshi M, BehboodiMoghadam Z, Gudarzi S, Haghani H. Effect of sage extract on hot flashes in postmenopausal women. J Complementary Medicine. 2013(4):46-57.
  30. Farzaneh F, Fatehi S, Sohrabi M-R, Alizadeh K. The effect of oral evening primrose oil on menopausal hot flashes: a randomized clinical trial. Arch Gynecol Obstet. 2013;288:1075-9.
  31. Steiner M. Postnatal depression: a few simple questions. Fam Pract. 2002;19(5):469-70.
  32. Samiei H, Sina S. Comparison of effects of soy plant with hormonal replacement therapy on menopausal symptoms. J of Babol University of medical sciences. 2005;7(4):36-43.
  33. Faure E, Chantre P, PMares. Effects of a standardized soy extract on hot flushes: a multicenter, double-blind, randomized, placebo-controlled study. j of Menopause. 2002;9(5):329-34.
  34. Enjezab B, khosravi HM, KHoshbin A, Farajkhoda T, Bokaie M. Effect of soy nuts on hot flashes in postmenopausal women. medical university of yazd Journal of Medical Sciences. 2009;17(4):242-8.
  35. Taku K, Melby M, Kronenberg F, Kurzer M, Messina M. Extracted or synthesized soybean isoflavones reduce menopausal hot flash frequency and severity: systematic review and meta-analysis of randomized controlled trials. Menopause (New York, NY). 2012;19(7):1-15.
  36. Ferrari A. Soy extract phytoestrogens with high dose of isoflavones for menopausal symptoms. J Obstet Gynaecol Res. 2009;35(6):1083-90.
  37. Menati L, Siyahposh A, Tadayon M. Clinical evaluation of the effect of liquorice plant Brgrgrftgy postmenopausal women in a randomized, double-blind comparison with hormone therapy. Medical Journal of medical university of ahvaz. 2011;9(2):157-67.
  38. Kazemian A, Bromandfar K, Ghanadi A, Norian K. Effect of vitagnus on hot flash. Shahrekord UnivMed Sci J. 2007;14(3):13-9.
  39. Taghizadeh Z, Rezaeipur A, Kazemnejad A, Mirsaeidi Z. Effect of Vitex agnus on Premature Menopause Symptoms. Hayat: J Facult Nurs Midwif Tehran Univ Med Sci. 2006;12(1):67-76.
  40. Tice J, Ettinger B, Ensrud K, Wallace R, Blackwell T, Cummings S. Phytoestrogen supplements for the treatment of hot flashes: the Isoflavone clover extract (ICE) study a randomized controlled trial. JAMA. 2003;290(2):97-207.
  41. Mainini G, Torella M, Donna MD, Esposito E, Ercolano S, Correa R, et al. Nonhormonal management of postmenopausal women: effects of a red clover based isoflavones supplementation on climacteric syndrome and cardiovascular risk serum profile. Clin Exp Obstet Gynecol. 2013;40(3):337-41.
  42. SHakeri F, Taavon S, Haghani H, Gooshegir A. Red clover supplements affect the physical symptoms of menopause. Journal of Research in Nursing and Midwifery / Sixth Special Seminar, nurses, midwives and Research. 2013:75-80.
  43. Leach M, Moore V. Black cohosh (Cimicifuga spp.) for menopausal symptoms. Cochrane Database of Systematic Reviews. 2012(9).
  44. Edzard E. The efficacy of herbal medicine an overview. Fundamental and Clinical Pharmacology. Fundamental and Clinical Pharmacology. 2005;19:405-9.
  45. Hamilton JL, Roemheld-Hamm B, Young DM, Jalba M, Dicicco-Bloom B. Complementary and alternative medicine inUS family medicine practices: a pilot qualitative study. Alternative Therapy Health Medical. 2008;14:22-7.
  46. Azadbakht M. Phytoestrogens. Journal of Medicinal Plants. 2006;6(21):1-10.
  47. Mazur W, Adlercreutz H. Overview ofnaturally occurring endocrine-active substances in the human diet in relation to human health. Niutrition. 2000;16(7/8):654-8.
  48. Dehshahri S, Aghababaei M, Rohina Y, GHanadi A. Phytoestrogens. Razi Journal of Medical Sciences. 2010;21(7):22-6.
  49. Nickavar B, Jamali B. Phytoestrogens. Razi. 2005;16(10):27-35
مجله زنان، مامایی و نازایی ایران
دوره 17، شماره 109 - شماره پیاپی 109
هفته سوم مرداد ماه 1393
مرداد 1393
صفحه 16-25

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