Introduction: Endometriosis is a common pelvic disorder in reproductive-aged women with considerable therapeutic challenges. Some herbal compounds show potential for its management. This study evaluated a combined Persian medicine herbal treatment on clinical symptoms and endometrioma volume.



Methods: In this three-month randomized double-blind trial, 60 women with endometriosis were assigned to intervention (n=30) or placebo (n=30). The intervention group received OCP plus Aslagh capsules, Bezori syrup, and topical chamomile oil, while controls received OCP and matched placebos. Clinical symptoms and endometrioma volume were assessed at baseline and study end using ultrasonography.



Results: The mean age was 32.53±4.86 in the intervention and 33.17±5.73 in the control group. Significant reductions in pelvic pain, dysmenorrhea, dyspareunia, dysuria, painful defecation, spotting, hypermenorrhea, and chronic fatigue were observed in the intervention group (P<0.05). Endometrioma volume significantly decreased in the intervention group (P=0.003), with no significant change in controls (P=0.120).



Conclusion: Adjunctive Persian herbal treatment alongside OCP was associated with significant clinical symptom and endometrioma volume reductions. However, due to concurrent OCP administration, the independent herbal effect could not be determined. Further appropriately designed studies are needed to evaluate its specific effec