Introduction: VNOTES refers to an emerging surgical field that allows access to the peritoneal cavity through vaginal incisions and has been shown to provide reduced postoperative pain, improved cosmetic appearance, reduced physiologic and immunologic responses to surgery, and the potential for faster recovery compared to laparoscopic surgery. In this study, we aimed to compare the vNOTES technique with conventional laparoscopy in an elective female sample.

Materials and Methods: The study population included women undergoing elective surgeries such as hysterectomy, salpingo-oophorectomy, and cystectomy. Initially, basic patient information including age, fertility, medical/surgical history, height, weight, blood pressure, and heart rate were recorded. In the next step, factors such as preoperative and postoperative hemoglobin and hematocrit, amount of aspirated hemoperitoneum, visual analog scale (VAS) pain score 12 hours, 24 hours, and 48 hours postoperatively, duration of surgery, and hospital stay were recorded. Surgical outcomes including uterine weight, hysterectomy indication, related procedures, operative time (OT), complications, intraoperative blood volume, and length of hospital stay were evaluated.

Results: The results showed that the average bleeding in the Vnote group was less compared to the other group, but these differences were not statistically significant (p=0.13). In contrast, the average length of stay in the Vnote group was longer compared to the other group, but it was not statistically significant (p=0.53). The average hemoglobin before and after the intervention in the