Introduction: The purpose of this study was to investigate the effects of various factors such as age, pap smear, HPV, status margin, colposcopy and their effects on the extent of disease remaining in Adenocarcinoma in situ hysterectomy patients.

Materials and methods: This study was conducted on the pathology of adenocarcinoma in response to their pathology, the variables of age, gravidity, menopause, HPV infection and high-risk and low-risk HPV types, Pap smear cytology, conization tissue sample size and the type of surgeon (senior or junior). ) Margin involvement in LEEP or conization was investigated according to the pathological response and grade of involvement in hysterectomy that is available. The information was classified in the questionnaire and then entered into spss software.

Results: In this study, age, gravidity, para, abortion, smoking, cytology results, HPV test, menopause, endocervical curettage results, CRYPT involvement, D&C results, did not have a statistically significant relationship with the rest (P>0.05) only the margin, And there was no statistically significant relationship between the type of cancer and the rest (P<0.05).

Conclusion: The result showed that a careful approach to adeno lesions with recognition of independent risk factors for recurrence is necessary.