مجله زنان، مامایی و نازایی ایران

مجله زنان، مامایی و نازایی ایران

ارزیابی اثربخشی کپسول خوراکی گزنه بر میل و رضایت جنسی در زنان یائسه: کارآزمایی بالینی تصادفی شده سه‌سوکور

نوع مقاله : اصیل پژوهشی

نویسندگان
نیلوفر آذربون 1
دکتر روشنک سالاری 2
سیدرضا مظلوم 3
دکتر بهناز سوییزی 4
دکتر راحله بابازاده 5
1 دانشجوی کارشناسی ارشد مامایی، کمیته تحقیقات دانشجویی، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی مشهد، مشهد، ایران.
2 استادیار گروه علوم دارویی در طب ایرانی، دانشکده طب ایرانی و مکمل، دانشگاه علوم پزشکی مشهد، مشهد، ایران
3 مربی گروه پرستاری داخلی و جراحی، مرکز تحقیقات مراقبت‌های پرستاری و مامایی، دانشگاه علوم پزشکی مشهد، مشهد، ایران.
4 استادیار گروه زنان و مامایی، فلوشیپ ناباروری، دانشکده پزشکی، دانشگاه علوم پزشکی سبزوار، سبزوار، ایران.
5 استادیار گروه مامایی، مرکز تحقیقات مراقبت‌های پرستاری و مامایی، دانشگاه علوم پزشکی مشهد، مشهد، ایران.
10.22038/ijogi.2026.91182.6551
چکیده
مقدمه: اختلال در میل جنسی، یکی از شایع‌ترین موارد اختلالات عملکرد جنسی در زنان یائسه است و زنانی که تمایل جنسی کمی دارند، از نظر رضایت جنسی نیز احساسات منفی دارند. مطالعه حاضر با هدف بررسی اثربخشی کپسول خوراکی گزنه بر میل و رضایت جنسی زنان یائسه انجام شد.
روش‌کار: این مطالعه کارآزمایی بالینی تصادفی در سال 1401 بر روی 60 زن یائسه که دارای اختلال در میل و رضایت جنسی بودند، در شهر سبزوار انجام شد. افراد به دو گروه‌ 30 نفره کپسول خوراکی گزنه و دارونما تقسیم شدند و روزانه یک عدد کپسول خوراکی 500 میلی­ گرمی گزنه یا دارونما به‌مدت 4 هفته استفاده کردند. ابزار اصلی جمع­آوری داده ­ها، پرسشنامه میل جنسی هالبرت و رضایت جنسی لارسون برای دسترسی به تغییرات متغیرهای وابسته در ابتدا و هفته چهارم و هشتم بعد از مداخله بود. تجزیه و تحلیل داده­ها با استفاده از نرم‌افزار آماری SPSS (نسخه 16) و آزمون‌های تی­ مستقل، من­ ویتنی، کای­اسکوئر و دقیق فیشر انجام شد. میزان p کمتر از 05/0 معنادار در نظر گرفته شد.
یافته ­ها: قبل از مداخله، میانگین و انحراف معیار نمره میل و رضایت جنسی در گروه مداخله 4/2±1/54 و 1/1±4/64 و در گروه کنترل 3/2±2/53 و 5/1±7/62 بود. در هفته چهارم مطالعه این مقادیر در گروه مداخله برای میل جنسی 0/3±1/57 (031/0=p) و برای رضایت جنسی 1/4±1/78 (001/0=p) و در گروه کنترل 3/2±7/53 و 5/1±3/63 بود. در هفته هشتم (4 هفته پس از پایان مداخله) میانگین و انحراف معیار نمره میل جنسی در گروه کنترل 3/2±6/53 و در گروه مداخله 5/2±1/56 بود (981/0=p). میانگین و انحراف معیار نمره رضایت جنسی در زنان یائسه گروه کنترل 3/1±9/63 و در گروه مداخله 5/1±1/76 بود (001/0=p).
نتیجه­ گیری: کپسول خوراکی گیاه گزنه سبب بهبود میزان میل و رضایت جنسی در زنان یائسه می­ شود و به‌دلیل نداشتن عوارض جانبی خاص، می ­تواند به‌عنوان یک درمان مکمل ایمن پیشنهاد گردد.
کلیدواژه‌ها
رضایت جنسی
گزنه
میل جنسی
یائسه
موضوعات

عنوان مقاله English

The Efficacy of Nettle Oral Capsules on Sexual Desire and Satisfaction in Menopausal Women: A Triple-Blind Randomized Clinical Trial

نویسندگان English

Niloufar Azarboon 1
Roshanak Salari 2
Seyed Reza Mazloom 3
Behnaz Soveizi 4
Raheleh Babazadeh 5
1 M.Sc. Student of Midwifery, Student Research Committee, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran.
2 Assistant Professor, Department of Pharmaceutical Sciences in Persian Medicine, School of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
3 Instructor, Department of Medical-Surgical Nursing, Nursing and Midwifery Care Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
4 Assistant Professor, Department of Obstetrics and Midwifery, Fellowship in Infertility, Faculty of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran.
5 Assistant Professor, Department of Midwifery, Nursing and Midwifery Care Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
چکیده English

Introduction: Sexual desire disorder is among the most prevalent forms of sexual dysfunction in the postmenopausal women, and women with low sexual desire also have negative feelings about sexual satisfaction. The present study was conducted with aim to investigate the efficacy of nettle oral capsules on sexual desire and satisfaction in menopausal women.
Methods: This randomized clinical trial study was conducted on 60 menopausal women who had sexual desire and satisfaction disorders in Sabzevar city in 2022. The subjectts were randomly divided into nettle oral capsule (n=30) and placebo (n=30) groups and consumed one 500 mg nettle oral capsule or placebo daily for 4 weeks. The main data collection tool was the Halbert Sexual Desire and Larson Sexual Satisfaction Questionnaire to access changes in dependent variables at baseline and the fourth and eighth weeks after the intervention. Statistical analyses were performed using SPSS software (version 16) and Independent t-test, Mann-Whitney, Chi-square, and Fisher's exact tests. P<0.05 was considered significant.
Results: Before the intervention, the mean of sexual desire and satisfaction scores in the intervention group were 54.1±2.4 and 64.4±1.1, and in the control group were 53.2±2.3 and 62.7±1.5. In the fourth week, these values were 57.1±3.0 (p=0.031) and 78.1±4.1 (p=0.001) in the intervention group and 53.7±2.3 and 63.3±1.5 in the control group. In eight week (4 weeks after the end of the intervention), the mean of sexual desire scores was 53.6±2.3 in the control group and 56.1±2.5 in the intervention group (p=0.981). The mean of sexual satisfaction scores was 63.9±1.3 in the control group and 76.1±1.5 in the intervention group (p=0.001).
Conclusion: Nettle oral capsules improve sexual desire and satisfaction in menopausal women and can be recommended as a safe complementary treatment due to the lack of specific side effects.

کلیدواژه‌ها English

Nettle
Menopause
Sexual Desire
Sexual Satisfaction
1.     Berek JS. BereK & Novaks Gynecology. 16nd ed. Wolters Kluwer: Lippincott Williams & Wilkins, USA; 2020.
2.     Nazari N, Karimi FZ, Rakhshandeh H, Mazloom SR, Azarhoush R. Comparing Urtica dioica to placebo on vaginal cytology and pH in postmenopausal women: A randomized, controlled trial. Journal of Herbal Medicine 2024; 48:100964.
3.     Freedman MA. Female sexual dysfunction. International journal of fertility and women's medicine 2002; 47(1):18-21.
4.     Mimoun S. Hypoactive sexual desire disorder, HSDD. Gynecologie, Obstetrique & Fertilite 2010; 39(1):28-31.
5.     Palacios S, Soler E, Ramírez M, Lilue M, Khorsandi D, Losa F. Effect of a multi-ingredient based food supplement on sexual function in women with low sexual desire. BMC women's Health 2019; 19(1):58.
6.     Hartmann U, Philippsohn S, Heiser K, Rüffer-Hesse C. Low sexual desire in midlife and older women: personality factors, psychosocial development, present sexuality. Menopause 2004; 11(6 Part 2 of 2):726-40.
7.     Castelo-Branco C, Blumel JE, Araya H, Riquelme R, Castro G, Haya J, et al. Prevalence of sexual dysfunction in a cohort of middle-aged women: influences of menopause and hormone replacement therapy. Journal of Obstetrics and Gynaecology 2003; 23(4):426-30.
8.     Addis IB, Van Den Eeden SK, Wassel-Fyr CL, Vittinghoff E, Brown JS, Thom DH, et al. Sexual activity and function in middle-aged and older women. Obstetrics & Gynecology 2006; 107(4):755-64.
9.     Sadeghi S, Yosefzadeh S, Mahrozadeh S, Mazloum SR, Rakhshandeh H. The effect of date palm pollen capsule on female sexual interest/arousal disorder in menopausal woman. Journal of Islamic and Iranian Traditional Medicine 2019; 9(4):287-96.
10.  Pazandeh F, Azar M, Ziaei T, Alavi Majd H. Survey on sexual satisfaction situation and some of affecting agents in postmenopausal women. Journal of Advances in Medical and Biomedical Research 2010; 18(71):81-9.
11.  Hertlein KM, Weeks GR, Gambescia N, editors. Systemic Sex Therapy. 2nd ed. New York: Routledge; 2015.
12.  Niloofar H, Raheleh B, Roshanak S, Jamshid J. Evaluation of the safety and efficacy of wormwood vaginal gel in improving sexual function and sexual satisfaction in women of reproductive age: A randomized, triple-blinds, placebo-controlled clinical trial. European Journal of Obstetrics & Gynecology and Reproductive Biology 2023; 280:1-6.
13.  Hertlein KM, Weeks GR, Gambescia N, editors. Systemic Sex Therapy. 2nd ed. New York: Routledge; 2015.
14.  Sadock BJ, Sadock VA, Ruiz P. Kaplan & Sadock's Synopsis of Psychiatry: Behavioral Sciences/Clinical Psychiatry. 11nd ed. Philadelphia (PA): Wolters Kluwer; 2015.
15.  Mahdavian M, Najmabadi KM, Hosseinzadeh H, Mirzaeian S, Aval SB, Esmaeeli H. Effect of the mixed herbal medicines extract (fennel, chamomile, and saffron) on menopause syndrome: a randomized controlled clinical trial. Journal of caring sciences 2019; 8(3):181.
16.  Majdi F, Farshbaf-Khalili A, Mirzayi M, Hakimi P, Hajizadeh K, Shahnazi M. Comparing the effects of nettle extract with combined oral contraceptives on improving clinical and paraclinical symptoms of polycystic Ovary Syndrome: A triple-blind randomized controlled clinical trial. Journal of Research Development in Nursing and Midwifery 2025; 22(2):44-51.
17.  Kargozar R, Salari R, Jarahi L, Yousefi M, Pourhoseini SA, Sahebkar-Khorasani M, et al. Urtica dioica in comparison with placebo and acupuncture: a new possibility for menopausal hot flashes: a randomized clinical trial. Complementary therapies in medicine 2019; 44:166-73.
18.  Nazari N, Karimi FZ, Rakhshandeh H, Mazloom SR, Azarhoush R. Comparing Urtica dioica to placebo on vaginal cytology and pH in postmenopausal women: A randomized, controlled trial. Journal of Herbal Medicine 2024; 48:100964.
19.  Karimi FZ, Nazari N, Rakhshandeh H, Mazloum SR. The effect of nettle vaginal cream on subjective symptoms of vaginal atrophy in postmenopausal women. European Journal of Obstetrics & Gynecology and Reproductive Biology 2023; 285:41-5.
20.  Esfade H, Mirabolghasemi G, Azarnia M. The joint effect of hydro-alcoholic extract of nettle root and metformin on ovarian tissue of diabetic model of Wistar rat. Nova Biologica Reperta 2019; 6(2):131-9.
21.  Sharokhyan Rezaee M, Farzinpour A, Farshad A, Hatfaludi T. The regulative effect of Urtica dioica on sex hormones imbalance: elevated follicle-stimulating hormone/luteinizing hormone ratio≥ 4.5 is associated with low performance in aged breeder quails. Italian Journal of Animal Science 2022; 21(1):142-52.
22.  Pourahmadi M, Bagheri M, Karimi Jashni H, Kargar Jahromi H, Zarei S. The effect of hydroalkoholic extract urtica dioica on concentrations of sex hormones in adult male rats. J Jahrom Univ Med Sci 2013; 10(4):25-9.
23.  Ghasemi N, Dehkordi N. Iranian herbal pharmacopeia. Herbal Pharmacopoeia Committee. Tehran: Ministry of Health and Medical Education, Department of Food and Drug Administration 2002:121-78.
24.  Yousefi N, Farsani K, Shakiba A, Hemmati S, Nabavi Hesar J. Halbert index of sexual desire (HISD) questionnaire validation. Clinical Psychology and Personality 2013; 11(2):107-18.
25.  Shafiee Z, Fatehizadeh M. The validity and reliability of thriving scale among the students of the University of Isfahan in 2017. Journal of Rafsanjan University of Medical Sciences 2018; 16(11):1013-24.
26.  Berek Jonathan S. BereK & Novaks Gynecology. Wolters Kluwer: Lippincott Williams & Wilkins, USA; 2020.
27.  Khalili M, Sahraee H, Hassanpour Ezati M. Anti-inflammatory effect of alcoholic stinging nettle extract in male NMRI rats. Journal of Medicinal Plants 2007; 6(22):46-53.
28.  Moslemi HR, Jamshidi K, Tavangar MM, Kafshdouzan K. Study of the effects of Urtica dioica ointment on the coetaneous wound healing in cattle. Journal of Medicinal Plants 2012; 11(42):177-82.
29.  Khadem Maboudi AA, Zayeri F, Sourteji A, Kariman N, Baghestani AR, SedghiFard Z, et al. The effect of nettle extract and mefenamic acid on reducing the symptoms of menorrhagia patients by joint modeling. Daneshvar Medicine 2014; 21(6):35-42.
30.  Khayatan J, Iravani MI, Moghimipour E, Haghighizadeh MH, Jelodarian P. The effect of red clover vaginal cream on sexual function in postmenopausal women: a randomized, controlled clinical trial. The Iranian Journal of Obstetrics, Gynecology and Infertility 2019; 22(8):26-34.
31.  Amiri Pebdani M, Taavoni S, Haghani H. The effect of the effect of ginkgo biloba extract on sexual activity in 50–60 years menopausal women. Complementary Medicine Journal 2012; 2(2):148-58.
32.  Davison SL, Davis SR. Androgenic hormones and aging—the link with female sexual function. Hormones and behavior 2011; 59(5):745-53.
33.  Najar S, Yaralizadeh M, Abedi P, Namjooyan F, Malehi O. Effect of fennel vaginal cream on dysparonia and sexual satisfaction among postmenopausal women: a double-blind randomized controlled trial. The Iranian Journal of Obstetrics, Gynecology and Infertility 2015; 18(171):8-16.
34.  Sadeghi S, Yosefzadeh S, Mahrozadeh S, Mazloum SR, Rakhshandeh H. The effect of date palm pollen capsule on female sexual interest/arousal disorder in menopausal woman. Journal of Islamic and Iranian Traditional Medicine 2019; 9(4):287-96.
35.  Tabatabaeichehr M, Nazari S, Bagheri M, Niazi I, Abassi Z, Soltani M, et al. Effect of oral saffron on sexual function of postmenopausal women: a clinical trial study. The Iranian Journal of Obstetrics, Gynecology and Infertility 2020; 22(12):46-53.
36.  Said AA, Otmani IS, Derfoufi S, Benmoussa A. Highlights on nutritional and therapeutic value of stinging nettle (Urtica dioica). International Journal of Pharmacy and Pharmaceutical Sciences 2015; 7(10):8-14.
مجله زنان، مامایی و نازایی ایران
دوره 29، شماره 1
فروردین 1405
صفحه 52-64