نوع مقاله : مروری
نویسندگان
1 دانشجوی کارشناسی ارشد علوم و صنایع غذایی، کمیته تحقیقات دانشجویی، دانشکده علوم تغذیه و صنایع غذایی، دانشگاه علوم پزشکی شهید بهشتی،
2 استادیار گروه تغذیه سلولی مولکولی، دانشکده علوم تغذیه و صنایع غذایی، انستیتو تحقیقات تغذیه ای و صنایع غذایی کشور، دانشگاه علوم
چکیده
کلیدواژه‌ها
موضوعات
عنوان مقاله [English]
نویسندگان [English]
Introduction: Infertility is defined as the failure to conceive after 12 months of regular unprotected intercourse. The gut and vaginal microbiome play significant roles in fertility outcomes, influenced by various factors including nutritional components. Probiotics, as one such factor, may affect fertility outcomes either directly by modulating microbial growth or indirectly through effects on the immune system and metabolism. This study examines the impact of probiotics on assisted reproductive technology (ART) outcomes.
Methods: In this systematic review, we searched Medline, Embase, Web of Science, Google Scholar, Science Direct, Scopus, Magiran, SID, ISC, and Cochrane Library databases without time restrictions using the keywords: probiotics, infertility, assisted reproductive technologies, IVF, and IUI.
Results: Among the seven studies reviewed, the administration of vaginal probiotics did not have a significant impact on overall outcomes of ARTs. Additionally, probiotic-prebiotic combinations in women under 40 years old and those with recurrent implantation failures increased pregnancy and live birth rates. Specifically, vaginal probiotics were found to reduce the incidence of miscarriage.
Conclusion: The findings indicate that while probiotics may be effective in certain aspects of fertility, the existing evidence is not definitive. The efficacy of probiotics is dependent on various factors, including the mode of administration, bacterial composition, and individual characteristics. Therefore, further studies with appropriate design are essential to determine the precise role of probiotics in reproductive medicine.
کلیدواژه‌ها [English]
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