مجله زنان، مامایی و نازایی ایران

مجله زنان، مامایی و نازایی ایران

بررسی ارتباط بین چاقی با خطر بروز سرطان پستان: مطالعه شاهد موردی

نوع مقاله : اصیل پژوهشی

نویسندگان
دکتر رضا افغانی 1
فاطیما شاهرخی 2
ذلیخا کرم الهی 3
1 استادیار گروه جراحی قفسه سینه، واحد توسعه تحقیقات بالینی، بیمارستان 5 آذر، دانشگاه علوم پزشکی گلستان، گرگان، ایران.
2 دانشجویی پزشکی، مرکز توسعه و تحقیقات بالینی 5 آذر، دانشکده پزشکی، دانشگاه علوم پزشکی گلستان، گرگان، ایران.
3 واحد توسعه و تحقیقات بالینی 5 آذر، دانشگاه علوم پزشکی گلستان، گرگان، ایران. دانشجوی دکتری بهداشت باروری، مرکز تحقیقات بهداشت باروری، باروری و ناباروری، پژوهشکده بهداشت، دانشگاه علوم پزشکی بابل، بابل، ایران.
10.22038/ijogi.2025.83996.6260
چکیده
مقدمه: مکانیسم­ های متعددی برای تأثیر چاقی بر بروز سرطان پستان و همچنین تأثیر آن بر میزان مرگ‌و‌میر ناشی از سرطان دخیل می­باشد. به‌علت وجود نتایج متناقض مطالعات در این زمینه، تأثیر آن هنوز مورد بحث می ­باشد، لذا مطالعه حاضر با هدف تعیین ارتباط بین چاقی با خطر بروز سرطان پستان در بیماران مراجعه کننده به مراکز آموزشی درمانی شهر گرگان انجام شد.
روش‌کار: در این مطالعه مورد- شاهدی، ۱۴۰ فرد واجد شرایط، در دو گروه مبتلا به سرطان (70 نفر) پستان و غیرمبتلا به سرطان پستان (70 نفر) وارد مطالعه شدند. قد، وزن و شاخص توده بدنی دو گروه قبل از عمل جراحی اندازه‌گیری شد. اطلاعات دموگرافیک و نتایج بافت‌شناسی با چک‌لیست جمع‌آوری و با استفاده از نرم‌افزار آماری SPSS (نسخه ۱۶) و آزمون‌های کای دو و تحلیل واریانس یک‌طرفه مورد تجزیه و تحلیل قرار گرفتند. میزان p کمتر از 05/0 معنی‌دار در نظر گرفته شد.
یافته ­ها: میانگین وزن در گروه مبتلا به سرطان پستان و غیرمبتلا به‌ترتیب 53/11±76/75 و 26/10±39/71 کیلوگرم (019/0=p) و میانگین شاخص توده بدنی در گروه مبتلا به سرطان پستان و غیرمبتلا به‌ترتیب 27/4±68/28 و 84/3±19/27 کیلوگرم بر متر مربع به‌دست آمد (032/0=p). بروز اختلالات فشارخون (001/0=p) و هایپرلیپیدمی (004/0=p) در گروه مبتلا به سرطان پستان شایع‌تر از گروه غیرمبتلا بود.
نتیجه­ گیری: در مبتلایان به سرطان پستان، میانگین وزن و شاخص توده بدنی بیشتر از افراد غیرمبتلا است. همچنین بروز اختلالات فشارخون و هایپرلیپیدمی در گروه مبتلا به سرطان پستان شایع‌تر بود.
کلیدواژه‌ها
چاقی
سرطان پستان
شاخص توده بدنی
موضوعات

عنوان مقاله English

Relationship between obesity and the risk of breast cancer: A case-control study

نویسندگان English

Reza Afghani 1
Fatima Shahrokhi 2
Zoleykha Karamelahi 3
1 Assistant Professor, Department of Thoracic Surgery, Clinical Research Development Unit (CRDU), 5azar Hospital, Golestan University of Medical Sciences, Gorgan, Iran.
2 Medical Student, Clinical Research Development Unit (CRDU), 5azar Hospital, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran.
3 Clinical Research Development Unit (CRDU), 5azar Hospital, Golestan University of Medical Sciences, Gorgan, Iran. PhD Student of Reproductive Health, Infertility and Reproductive Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
چکیده English

Introduction: Several mechanisms are involved in the effect of obesity on the occurrence of breast cancer as well as its effect on cancer mortality. Since there are contradictory results  in this field, its effectiveness is still debated. Therefore, the present study was conducted with aim to determine the relationship between obesity and the risk of breast cancer in patients referred to the educational and medical centers in Gorgan.Methods: In this case-control study, 140 qualified people were enrolled in two groups with breast cancer (n=70) and those without breast cancer (n=70). Height, weight and body mass index of two groups were measured before the surgery. Demographic information and histological results were collected by a checklist and then analyzed with SPSS software (version 16) and chi-square test and One-way ANOVA. P<0.05 was considered significant.
Results: The mean weight in women with and without breast cancer was 75.76±11.53 and 71.39±10.26 kg, respectively (P=0.019). Also, the mean body mass index of patients with and without breast cancer was 28.68±4.27 and 27.19 ± 3.84 kg/m2 (P=0.032). The incidence of hypertension (P=0.001) and hyperlipidemia (P=0.004) was more common in patients with breast cancer.
Conclusion: The results of the present study showed that the mean weight and body mass index was higher in  patients with breast cancer than those without breast cancer. Also, the incidence of hypertension and hyperlipidemia was more common in the breast cancer group.

کلیدواژه‌ها English

Breast Cancer
BMI
Obesity
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مجله زنان، مامایی و نازایی ایران
دوره 28، شماره 2
اردیبهشت 1404
صفحه 22-34