نوع مقاله : اصیل پژوهشی
نویسندگان
1 دستیار تخصصی رادیولوژی، دانشکده پزشکی، دانشگاه علوم پزشکی مشهد، مشهد، ایران.
2 استادیار و فلوشیپ پرینئاتولوژی، گروه زنان و مامایی، دانشکده پزشکی، دانشگاه علوم پزشکی مشهد، مشهد، ایران.
3 دانشیار گروه رادیولوژی، دانشکده پزشکی، دانشگاه علوم پزشکی مشهد، مشهد، ایران.
4 استاد گروه پزشکی اجتماعی، دانشکده پزشکی، دانشگاه علوم پزشکی مشهد، مشهد، ایران.
5 استاد گروه پاتولوژی، دانشکده پزشکی، دانشگاه علوم پزشکی مشهد، مشهد، ایران.
چکیده
کلیدواژهها
موضوعات
عنوان مقاله [English]
نویسندگان [English]
Introduction: Neoadjuvant chemotherapy is used with aim to shrink tumors, allowing breast-conserving surgery and targeting micro-metastases. This study was performed with aim to investigate the correlation between initial radiological findings of patients to predict chemotherapy response based on pathology.
Methods: This descriptive-analytical study was conducted in 1400-1403 on 151 patients referred to Omid Hospital in Mashhad who were diagnosed with breast cancer by ultrasound and mammography and were candidates for neoadjuvant chemotherapy. The response rate to neoadjuvant chemotherapy was determined by the pathologist based on the CAP protocol from 0 to 3. The level of IHC markers was also determined by the pathologist. Data analysis was performed using SPSS statistical software (version 27) and Kruskal-Wallis and Mann-Whitney tests. A p value of less than 0.05 was considered significant.
Results: A significant correlation was observed between the mean of her2neu and Ki67 with the mammographic shape of the mass and between the expression level of ER and PR with the Brest mammographic composition (P<0.05). Also, a statistically significant correlation was observed between the mean ER with the sonographic shape of the mass and the mean Ki67 and ER with the sonographic margin of the mass (P<0.05). The sonographic margin of the mass also showed a significant decreasing trend with the response to neoadjuvant chemotherapy in patients with breast cancer (P<0.05).
Conclusion: There was a statistically significant relationship between mammographic mass shape and composition with IHC markers and sonographic mass shape and margin with the amount of IHC markers Also, patients with oval shape and micro-lobulated margin clearly showed a better response to treatment based on the CAP protocol, which indicated a better response to treatment in the group of patients with oval shape and micro-lobulated margin on ultrasound.
کلیدواژهها [English]